| Full name: N-acetylglucosamine kinase | Alias Symbol: GNK | ||
| Type: protein-coding gene | Cytoband: 2p13.3 | ||
| Entrez ID: 55577 | HGNC ID: HGNC:17174 | Ensembl Gene: ENSG00000124357 | OMIM ID: 606828 |
| Drug and gene relationship at DGIdb | |||
Expression of NAGK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NAGK | 55577 | 218231_at | -1.1970 | 0.0655 | |
| GSE20347 | NAGK | 55577 | 218231_at | -1.7924 | 0.0000 | |
| GSE23400 | NAGK | 55577 | 218231_at | -1.2005 | 0.0000 | |
| GSE26886 | NAGK | 55577 | 218231_at | -3.1947 | 0.0000 | |
| GSE29001 | NAGK | 55577 | 218231_at | -1.6950 | 0.0004 | |
| GSE38129 | NAGK | 55577 | 218231_at | -1.1387 | 0.0000 | |
| GSE45670 | NAGK | 55577 | 218231_at | -0.7219 | 0.0020 | |
| GSE53622 | NAGK | 55577 | 72311 | -1.2410 | 0.0000 | |
| GSE53624 | NAGK | 55577 | 72311 | -1.5923 | 0.0000 | |
| GSE63941 | NAGK | 55577 | 218231_at | -0.7741 | 0.1426 | |
| GSE77861 | NAGK | 55577 | 218231_at | -1.0474 | 0.0086 | |
| GSE97050 | NAGK | 55577 | A_23_P154208 | -0.3581 | 0.4062 | |
| SRP007169 | NAGK | 55577 | RNAseq | -2.8520 | 0.0000 | |
| SRP008496 | NAGK | 55577 | RNAseq | -2.6021 | 0.0000 | |
| SRP064894 | NAGK | 55577 | RNAseq | -1.1279 | 0.0000 | |
| SRP133303 | NAGK | 55577 | RNAseq | -1.2049 | 0.0000 | |
| SRP159526 | NAGK | 55577 | RNAseq | -1.4034 | 0.0000 | |
| SRP193095 | NAGK | 55577 | RNAseq | -1.4270 | 0.0000 | |
| SRP219564 | NAGK | 55577 | RNAseq | -0.9680 | 0.0098 | |
| TCGA | NAGK | 55577 | RNAseq | 0.0993 | 0.1428 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by NAGK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NAGK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NAGK | 55577 | 11 | 1 | 18 | |
| GSE20123 | NAGK | 55577 | 11 | 1 | 18 | |
| GSE43470 | NAGK | 55577 | 3 | 0 | 40 | |
| GSE46452 | NAGK | 55577 | 2 | 3 | 54 | |
| GSE47630 | NAGK | 55577 | 7 | 0 | 33 | |
| GSE54993 | NAGK | 55577 | 0 | 6 | 64 | |
| GSE54994 | NAGK | 55577 | 11 | 0 | 42 | |
| GSE60625 | NAGK | 55577 | 0 | 3 | 8 | |
| GSE74703 | NAGK | 55577 | 3 | 0 | 33 | |
| GSE74704 | NAGK | 55577 | 9 | 0 | 11 | |
| TCGA | NAGK | 55577 | 37 | 2 | 57 |
Total number of gains: 94; Total number of losses: 16; Total Number of normals: 378.
Somatic mutations of NAGK:
Generating mutation plots.
Highly correlated genes for NAGK:
Showing top 20/1904 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NAGK | VSIG10L | 0.870053 | 6 | 0 | 6 |
| NAGK | CYSRT1 | 0.864751 | 6 | 0 | 6 |
| NAGK | ENDOU | 0.856635 | 11 | 0 | 11 |
| NAGK | SFTA2 | 0.854251 | 4 | 0 | 4 |
| NAGK | SLC16A6 | 0.852309 | 11 | 0 | 11 |
| NAGK | BLNK | 0.848517 | 11 | 0 | 11 |
| NAGK | FCHO2 | 0.848376 | 7 | 0 | 7 |
| NAGK | FAM214A | 0.842445 | 6 | 0 | 6 |
| NAGK | EPB41L3 | 0.840478 | 11 | 0 | 11 |
| NAGK | GYS2 | 0.838754 | 10 | 0 | 10 |
| NAGK | SMIM5 | 0.837852 | 6 | 0 | 6 |
| NAGK | CXCR2 | 0.831826 | 11 | 0 | 11 |
| NAGK | ARHGAP27 | 0.829757 | 7 | 0 | 7 |
| NAGK | IL36A | 0.829472 | 10 | 0 | 10 |
| NAGK | PLEKHA7 | 0.829405 | 7 | 0 | 7 |
| NAGK | RANBP9 | 0.828879 | 11 | 0 | 11 |
| NAGK | EPGN | 0.827711 | 3 | 0 | 3 |
| NAGK | EHD3 | 0.82722 | 12 | 0 | 11 |
| NAGK | DEGS2 | 0.826921 | 6 | 0 | 6 |
| NAGK | MUC15 | 0.824679 | 6 | 0 | 6 |
For details and further investigation, click here
