POLE4

 

Full name: DNA polymerase epsilon 4, accessory subunit Alias Symbol: p12
Type: protein-coding gene Cytoband: 2p12
Entrez ID: 56655 HGNC ID: HGNC:18755 Ensembl Gene: ENSG00000115350 OMIM ID: 607269
Drug and gene relationship at DGIdb
Screen Evidence:

 

POLE4 involved pathways:

KEGG pathway Description View
hsa05166HTLV-I infection

 

Expression of POLE4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLE4 56655 225844_at 0.5211 0.1406
GSE26886 POLE4 56655 225844_at 0.8545 0.0000
GSE45670 POLE4 56655 225844_at 0.4042 0.0074
GSE53622 POLE4 56655 149267 0.5636 0.0000
GSE53624 POLE4 56655 85536 0.6452 0.0000
GSE63941 POLE4 56655 225844_at -0.0571 0.8999
GSE77861 POLE4 56655 225844_at 0.4654 0.0944
GSE97050 POLE4 56655 A_23_P154234 0.3036 0.2466
SRP007169 POLE4 56655 RNAseq 0.6161 0.2945
SRP008496 POLE4 56655 RNAseq 0.5696 0.1191
SRP064894 POLE4 56655 RNAseq 0.7177 0.0266
SRP133303 POLE4 56655 RNAseq 0.5666 0.0034
SRP159526 POLE4 56655 RNAseq 0.9410 0.0069
SRP193095 POLE4 56655 RNAseq 0.2308 0.1619
SRP219564 POLE4 56655 RNAseq 0.3557 0.2855
TCGA POLE4 56655 RNAseq 0.0955 0.1339

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by POLE4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLE4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLE4 56655 9 2 19
GSE20123 POLE4 56655 9 2 19
GSE43470 POLE4 56655 4 0 39
GSE46452 POLE4 56655 2 3 54
GSE47630 POLE4 56655 7 0 33
GSE54993 POLE4 56655 0 6 64
GSE54994 POLE4 56655 10 0 43
GSE60625 POLE4 56655 0 3 8
GSE74703 POLE4 56655 4 0 32
GSE74704 POLE4 56655 8 0 12
TCGA POLE4 56655 37 2 57

Total number of gains: 90; Total number of losses: 18; Total Number of normals: 380.  

 

Somatic mutations of POLE4:

 

Generating mutation plots.

 

Highly correlated genes for POLE4:

 

Showing top 20/592 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLE4MYH90.796879404
POLE4SNAI20.789036505
POLE4FEN10.78877505
POLE4CDCA50.746714707
POLE4CDC200.746468707
POLE4LENG10.744181303
POLE4SAV10.74055303
POLE4EFNB10.739727505
POLE4TK10.738265707
POLE4GALNT180.73356606
POLE4HAUS80.726169707
POLE4CDC450.722114606
POLE4ALKBH50.71562403
POLE4POLD10.712633504
POLE4CBX30.711661707
POLE4TXNDC120.710351606
POLE4ZNF1140.709109404
POLE4LILRA30.707836303
POLE4EXO10.705248707
POLE4CORT0.70482303

For details and further investigation, click here