| Full name: cholinergic receptor nicotinic epsilon subunit | Alias Symbol: ACHRE | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 1145 | HGNC ID: HGNC:1966 | Ensembl Gene: ENSG00000108556 | OMIM ID: 100725 |
| Drug and gene relationship at DGIdb | |||
Expression of CHRNE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNE | 1145 | 207274_at | 0.1738 | 0.3742 | |
| GSE20347 | CHRNE | 1145 | 207274_at | -0.0898 | 0.2177 | |
| GSE23400 | CHRNE | 1145 | 207274_at | -0.0118 | 0.7182 | |
| GSE26886 | CHRNE | 1145 | 207274_at | 0.0848 | 0.6346 | |
| GSE29001 | CHRNE | 1145 | 207274_at | -0.0385 | 0.8276 | |
| GSE38129 | CHRNE | 1145 | 207274_at | -0.0473 | 0.5694 | |
| GSE45670 | CHRNE | 1145 | 207274_at | 0.0530 | 0.7527 | |
| GSE53622 | CHRNE | 1145 | 47208 | 0.4541 | 0.0000 | |
| GSE53624 | CHRNE | 1145 | 47208 | 0.5740 | 0.0000 | |
| GSE63941 | CHRNE | 1145 | 207274_at | 0.2419 | 0.0800 | |
| GSE77861 | CHRNE | 1145 | 207274_at | -0.2086 | 0.2724 | |
| GSE97050 | CHRNE | 1145 | A_23_P304279 | 0.1909 | 0.4593 | |
| SRP133303 | CHRNE | 1145 | RNAseq | -0.2764 | 0.3608 | |
| SRP159526 | CHRNE | 1145 | RNAseq | 1.0758 | 0.1174 | |
| SRP219564 | CHRNE | 1145 | RNAseq | 0.4706 | 0.2465 | |
| TCGA | CHRNE | 1145 | RNAseq | -0.1999 | 0.3975 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHRNE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNE | 1145 | 5 | 2 | 23 | |
| GSE20123 | CHRNE | 1145 | 5 | 3 | 22 | |
| GSE43470 | CHRNE | 1145 | 1 | 6 | 36 | |
| GSE46452 | CHRNE | 1145 | 34 | 1 | 24 | |
| GSE47630 | CHRNE | 1145 | 7 | 1 | 32 | |
| GSE54993 | CHRNE | 1145 | 4 | 3 | 63 | |
| GSE54994 | CHRNE | 1145 | 5 | 9 | 39 | |
| GSE60625 | CHRNE | 1145 | 4 | 0 | 7 | |
| GSE74703 | CHRNE | 1145 | 1 | 3 | 32 | |
| GSE74704 | CHRNE | 1145 | 3 | 1 | 16 | |
| TCGA | CHRNE | 1145 | 18 | 21 | 57 |
Total number of gains: 87; Total number of losses: 50; Total Number of normals: 351.
Somatic mutations of CHRNE:
Generating mutation plots.
Highly correlated genes for CHRNE:
Showing top 20/415 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNE | GIT1 | 0.778889 | 3 | 0 | 3 |
| CHRNE | BARHL1 | 0.737829 | 4 | 0 | 4 |
| CHRNE | TRIM3 | 0.730604 | 3 | 0 | 3 |
| CHRNE | PRR23C | 0.716357 | 3 | 0 | 3 |
| CHRNE | ZNF467 | 0.712478 | 4 | 0 | 4 |
| CHRNE | ALG11 | 0.711312 | 3 | 0 | 3 |
| CHRNE | SZT2 | 0.710322 | 4 | 0 | 4 |
| CHRNE | ASB3 | 0.70415 | 3 | 0 | 3 |
| CHRNE | USP5 | 0.699835 | 3 | 0 | 3 |
| CHRNE | WDR27 | 0.699013 | 3 | 0 | 3 |
| CHRNE | UBE2O | 0.696163 | 4 | 0 | 4 |
| CHRNE | KIF5A | 0.692254 | 4 | 0 | 3 |
| CHRNE | HPS4 | 0.688254 | 3 | 0 | 3 |
| CHRNE | OR1L6 | 0.687785 | 3 | 0 | 3 |
| CHRNE | CCNJ | 0.68772 | 3 | 0 | 3 |
| CHRNE | USP36 | 0.679389 | 3 | 0 | 3 |
| CHRNE | TSPAN16 | 0.678918 | 3 | 0 | 3 |
| CHRNE | SMO | 0.674355 | 3 | 0 | 3 |
| CHRNE | RNF187 | 0.673738 | 3 | 0 | 3 |
| CHRNE | TP53I11 | 0.671569 | 4 | 0 | 4 |
For details and further investigation, click here
