USP5

 

Full name: ubiquitin specific peptidase 5 Alias Symbol: IsoT
Type: protein-coding gene Cytoband: 12p13
Entrez ID: 8078 HGNC ID: HGNC:12628 Ensembl Gene: ENSG00000111667 OMIM ID: 601447
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of USP5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 USP5 8078 206031_s_at 0.3368 0.3955
GSE20347 USP5 8078 206031_s_at 0.0766 0.4910
GSE23400 USP5 8078 206031_s_at 0.0931 0.0275
GSE26886 USP5 8078 206031_s_at 0.2520 0.0454
GSE29001 USP5 8078 206031_s_at -0.1422 0.3553
GSE38129 USP5 8078 206031_s_at 0.0275 0.7912
GSE45670 USP5 8078 206031_s_at 0.0833 0.4783
GSE53622 USP5 8078 10714 0.3399 0.0000
GSE53624 USP5 8078 10714 0.4049 0.0000
GSE63941 USP5 8078 206031_s_at 1.3818 0.0004
GSE77861 USP5 8078 206031_s_at 0.2675 0.0796
GSE97050 USP5 8078 A_23_P64954 0.2376 0.3798
SRP007169 USP5 8078 RNAseq 0.8290 0.0665
SRP008496 USP5 8078 RNAseq 0.5917 0.0554
SRP064894 USP5 8078 RNAseq 0.3558 0.0870
SRP133303 USP5 8078 RNAseq 0.3971 0.0700
SRP159526 USP5 8078 RNAseq 0.4233 0.0740
SRP193095 USP5 8078 RNAseq 0.1790 0.1444
SRP219564 USP5 8078 RNAseq 0.2653 0.3193
TCGA USP5 8078 RNAseq 0.1349 0.0036

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by USP5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of USP5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 USP5 8078 9 3 18
GSE20123 USP5 8078 9 3 18
GSE43470 USP5 8078 8 3 32
GSE46452 USP5 8078 10 1 48
GSE47630 USP5 8078 12 2 26
GSE54993 USP5 8078 1 10 59
GSE54994 USP5 8078 10 2 41
GSE60625 USP5 8078 0 1 10
GSE74703 USP5 8078 7 2 27
GSE74704 USP5 8078 5 3 12
TCGA USP5 8078 40 6 50

Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.  

 

Somatic mutations of USP5:

 

Generating mutation plots.

 

Highly correlated genes for USP5:

 

Showing top 20/739 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
USP5PRELID10.780732303
USP5TMEM2220.777346303
USP5ZNF8370.756813303
USP5XKR80.72881303
USP5DDA10.727102505
USP5DRAP10.726047404
USP5PFN10.71057404
USP5RAC20.707807303
USP5CDC14A0.707343303
USP5BIK0.703119404
USP5CHRNE0.699835303
USP5SCAF10.698197404
USP5HIVEP30.698084303
USP5PPP5C0.691289706
USP5ZYX0.691215303
USP5C11orf680.691115303
USP5MLF20.69069112012
USP5GRAMD1B0.688278303
USP5CD330.687661303
USP5NHLH10.686076404

For details and further investigation, click here