| Full name: kinesin family member 5A | Alias Symbol: D12S1889|NKHC|MY050 | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 3798 | HGNC ID: HGNC:6323 | Ensembl Gene: ENSG00000155980 | OMIM ID: 602821 |
| Drug and gene relationship at DGIdb | |||
KIF5A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04728 | Dopaminergic synapse |
Expression of KIF5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIF5A | 3798 | 223933_at | 0.0990 | 0.6768 | |
| GSE20347 | KIF5A | 3798 | 205318_at | 0.1170 | 0.2884 | |
| GSE23400 | KIF5A | 3798 | 205318_at | -0.0687 | 0.1455 | |
| GSE26886 | KIF5A | 3798 | 205318_at | -0.0210 | 0.8919 | |
| GSE29001 | KIF5A | 3798 | 205318_at | -0.1444 | 0.6449 | |
| GSE38129 | KIF5A | 3798 | 205318_at | -0.0268 | 0.8268 | |
| GSE45670 | KIF5A | 3798 | 229921_at | 0.0918 | 0.3183 | |
| GSE53622 | KIF5A | 3798 | 127912 | -0.0842 | 0.6225 | |
| GSE53624 | KIF5A | 3798 | 127912 | 0.0947 | 0.4276 | |
| GSE63941 | KIF5A | 3798 | 205318_at | 0.1871 | 0.2487 | |
| GSE77861 | KIF5A | 3798 | 205318_at | -0.0670 | 0.4861 | |
| GSE97050 | KIF5A | 3798 | A_24_P93948 | -0.2267 | 0.7619 | |
| SRP133303 | KIF5A | 3798 | RNAseq | -0.2421 | 0.4793 | |
| SRP219564 | KIF5A | 3798 | RNAseq | -0.4442 | 0.4788 | |
| TCGA | KIF5A | 3798 | RNAseq | -1.1650 | 0.0348 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KIF5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIF5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIF5A | 3798 | 7 | 1 | 22 | |
| GSE20123 | KIF5A | 3798 | 7 | 0 | 23 | |
| GSE43470 | KIF5A | 3798 | 2 | 0 | 41 | |
| GSE46452 | KIF5A | 3798 | 8 | 1 | 50 | |
| GSE47630 | KIF5A | 3798 | 10 | 2 | 28 | |
| GSE54993 | KIF5A | 3798 | 0 | 5 | 65 | |
| GSE54994 | KIF5A | 3798 | 4 | 1 | 48 | |
| GSE60625 | KIF5A | 3798 | 0 | 0 | 11 | |
| GSE74703 | KIF5A | 3798 | 2 | 0 | 34 | |
| GSE74704 | KIF5A | 3798 | 5 | 0 | 15 | |
| TCGA | KIF5A | 3798 | 14 | 10 | 72 |
Total number of gains: 59; Total number of losses: 20; Total Number of normals: 409.
Somatic mutations of KIF5A:
Generating mutation plots.
Highly correlated genes for KIF5A:
Showing top 20/680 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIF5A | IFNA17 | 0.77268 | 4 | 0 | 4 |
| KIF5A | SLCO1C1 | 0.756032 | 4 | 0 | 4 |
| KIF5A | FABP7 | 0.75514 | 3 | 0 | 3 |
| KIF5A | CYP3A4 | 0.748721 | 4 | 0 | 4 |
| KIF5A | SYT13 | 0.742252 | 3 | 0 | 3 |
| KIF5A | MTAP | 0.733452 | 4 | 0 | 4 |
| KIF5A | UBE2D4 | 0.723298 | 5 | 0 | 4 |
| KIF5A | BCAN | 0.719149 | 5 | 0 | 5 |
| KIF5A | CDC25C | 0.716274 | 3 | 0 | 3 |
| KIF5A | COLEC10 | 0.716164 | 6 | 0 | 6 |
| KIF5A | MAP3K19 | 0.704231 | 6 | 0 | 6 |
| KIF5A | CHRNE | 0.692254 | 4 | 0 | 3 |
| KIF5A | SLC17A4 | 0.690786 | 5 | 0 | 5 |
| KIF5A | FCGR2C | 0.690211 | 3 | 0 | 3 |
| KIF5A | KRT38 | 0.68865 | 4 | 0 | 3 |
| KIF5A | BCKDHB | 0.685246 | 3 | 0 | 3 |
| KIF5A | CST8 | 0.685132 | 3 | 0 | 3 |
| KIF5A | CRHR2 | 0.684292 | 4 | 0 | 4 |
| KIF5A | S100G | 0.684204 | 3 | 0 | 3 |
| KIF5A | TAAR2 | 0.681798 | 5 | 0 | 5 |
For details and further investigation, click here
