CHUK

 

Full name: component of inhibitor of nuclear factor kappa B kinase complex Alias Symbol: IKK1|IKK-alpha|IkBKA|NFKBIKA|IKKA
Type: protein-coding gene Cytoband: 10q24.31
Entrez ID: 1147 HGNC ID: HGNC:1974 Ensembl Gene: ENSG00000213341 OMIM ID: 600664
Drug and gene relationship at DGIdb
Screen Evidence:

 

CHUK involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04068FoxO signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04668TNF signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05166HTLV-I infection
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer

 

Expression of CHUK:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CHUK 1147 209666_s_at 0.3608 0.3577
GSE20347 CHUK 1147 209666_s_at 0.2565 0.1212
GSE23400 CHUK 1147 209666_s_at 0.2496 0.0000
GSE26886 CHUK 1147 209666_s_at -0.0547 0.8612
GSE29001 CHUK 1147 209666_s_at 0.3901 0.0397
GSE38129 CHUK 1147 209666_s_at 0.4027 0.0001
GSE45670 CHUK 1147 209666_s_at 0.2148 0.1669
GSE53622 CHUK 1147 140034 0.0741 0.2635
GSE53624 CHUK 1147 140034 0.3260 0.0000
GSE63941 CHUK 1147 209666_s_at -1.3084 0.0033
GSE77861 CHUK 1147 209666_s_at 0.2677 0.4437
GSE97050 CHUK 1147 A_33_P3258141 0.3306 0.1805
SRP007169 CHUK 1147 RNAseq 1.1739 0.0223
SRP008496 CHUK 1147 RNAseq 1.1036 0.0007
SRP064894 CHUK 1147 RNAseq -0.0727 0.7436
SRP133303 CHUK 1147 RNAseq 0.5244 0.0000
SRP159526 CHUK 1147 RNAseq 0.0931 0.8264
SRP193095 CHUK 1147 RNAseq 0.1190 0.2529
SRP219564 CHUK 1147 RNAseq -0.0039 0.9861
TCGA CHUK 1147 RNAseq -0.1084 0.0305

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by CHUK expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CHUK:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CHUK 1147 1 8 21
GSE20123 CHUK 1147 1 7 22
GSE43470 CHUK 1147 0 7 36
GSE46452 CHUK 1147 0 11 48
GSE47630 CHUK 1147 2 14 24
GSE54993 CHUK 1147 8 0 62
GSE54994 CHUK 1147 1 12 40
GSE60625 CHUK 1147 0 0 11
GSE74703 CHUK 1147 0 5 31
GSE74704 CHUK 1147 0 4 16
TCGA CHUK 1147 5 28 63

Total number of gains: 18; Total number of losses: 96; Total Number of normals: 374.  

 

Somatic mutations of CHUK:

 

Generating mutation plots.

 

Highly correlated genes for CHUK:

 

Showing top 20/664 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CHUKZNF350.836188303
CHUKMGMT0.769827303
CHUKEIF4G30.758298303
CHUKZSCAN290.757274303
CHUKIFT740.747946303
CHUKRWDD40.747457303
CHUKC9orf720.745855303
CHUKZMAT30.741068303
CHUKNUDT90.73991303
CHUKTMEM126B0.739595303
CHUKSCAF40.729512303
CHUKDDX3X0.728021303
CHUKSGTB0.725384303
CHUKFKBP70.725354303
CHUKAGTPBP10.723219303
CHUKPPIL40.720032403
CHUKPRPF4B0.719012303
CHUKIREB20.718002303
CHUKNAA250.71776303
CHUKLARP1B0.713702403

For details and further investigation, click here