| Full name: pre-mRNA processing factor 4B | Alias Symbol: Prp4|PR4H|KIAA0536 | ||
| Type: protein-coding gene | Cytoband: 6p25.2 | ||
| Entrez ID: 8899 | HGNC ID: HGNC:17346 | Ensembl Gene: ENSG00000112739 | OMIM ID: 602338 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PRPF4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRPF4B | 8899 | 202126_at | 0.4485 | 0.2772 | |
| GSE20347 | PRPF4B | 8899 | 202126_at | 0.0250 | 0.9040 | |
| GSE23400 | PRPF4B | 8899 | 211090_s_at | 0.5003 | 0.0000 | |
| GSE26886 | PRPF4B | 8899 | 202126_at | 0.0735 | 0.6926 | |
| GSE29001 | PRPF4B | 8899 | 202127_at | 0.3589 | 0.1910 | |
| GSE38129 | PRPF4B | 8899 | 202126_at | 0.0155 | 0.9052 | |
| GSE45670 | PRPF4B | 8899 | 202126_at | -0.0801 | 0.5047 | |
| GSE53622 | PRPF4B | 8899 | 55627 | 0.1448 | 0.0053 | |
| GSE53624 | PRPF4B | 8899 | 58522 | -0.1624 | 0.0191 | |
| GSE63941 | PRPF4B | 8899 | 202126_at | -0.3068 | 0.4867 | |
| GSE77861 | PRPF4B | 8899 | 202126_at | -0.0209 | 0.9671 | |
| GSE97050 | PRPF4B | 8899 | A_23_P168240 | 0.0227 | 0.9482 | |
| SRP007169 | PRPF4B | 8899 | RNAseq | 0.7654 | 0.0678 | |
| SRP008496 | PRPF4B | 8899 | RNAseq | 0.9338 | 0.0003 | |
| SRP064894 | PRPF4B | 8899 | RNAseq | -0.1050 | 0.6655 | |
| SRP133303 | PRPF4B | 8899 | RNAseq | -0.0479 | 0.7587 | |
| SRP159526 | PRPF4B | 8899 | RNAseq | 0.1020 | 0.6008 | |
| SRP193095 | PRPF4B | 8899 | RNAseq | -0.1305 | 0.0999 | |
| SRP219564 | PRPF4B | 8899 | RNAseq | -0.1458 | 0.6953 | |
| TCGA | PRPF4B | 8899 | RNAseq | -0.0689 | 0.1194 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRPF4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRPF4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRPF4B | 8899 | 4 | 5 | 21 | |
| GSE20123 | PRPF4B | 8899 | 4 | 5 | 21 | |
| GSE43470 | PRPF4B | 8899 | 8 | 2 | 33 | |
| GSE46452 | PRPF4B | 8899 | 1 | 10 | 48 | |
| GSE47630 | PRPF4B | 8899 | 7 | 8 | 25 | |
| GSE54993 | PRPF4B | 8899 | 1 | 1 | 68 | |
| GSE54994 | PRPF4B | 8899 | 10 | 3 | 40 | |
| GSE60625 | PRPF4B | 8899 | 0 | 1 | 10 | |
| GSE74703 | PRPF4B | 8899 | 7 | 2 | 27 | |
| GSE74704 | PRPF4B | 8899 | 2 | 2 | 16 | |
| TCGA | PRPF4B | 8899 | 16 | 29 | 51 |
Total number of gains: 60; Total number of losses: 68; Total Number of normals: 360.
Somatic mutations of PRPF4B:
Generating mutation plots.
Highly correlated genes for PRPF4B:
Showing top 20/384 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRPF4B | SLC35B3 | 0.793306 | 4 | 0 | 4 |
| PRPF4B | RRP36 | 0.785299 | 3 | 0 | 3 |
| PRPF4B | DYRK2 | 0.784002 | 3 | 0 | 3 |
| PRPF4B | ZNF765 | 0.779661 | 3 | 0 | 3 |
| PRPF4B | NASP | 0.772425 | 3 | 0 | 3 |
| PRPF4B | ZNF121 | 0.762246 | 3 | 0 | 3 |
| PRPF4B | GSK3B | 0.754895 | 3 | 0 | 3 |
| PRPF4B | LTV1 | 0.754729 | 3 | 0 | 3 |
| PRPF4B | MRPS9 | 0.738833 | 3 | 0 | 3 |
| PRPF4B | THAP5 | 0.737592 | 3 | 0 | 3 |
| PRPF4B | CIR1 | 0.735931 | 3 | 0 | 3 |
| PRPF4B | NUB1 | 0.723461 | 3 | 0 | 3 |
| PRPF4B | CHUK | 0.719012 | 3 | 0 | 3 |
| PRPF4B | SEPHS1 | 0.718327 | 3 | 0 | 3 |
| PRPF4B | XAF1 | 0.716089 | 3 | 0 | 3 |
| PRPF4B | SLC25A14 | 0.711287 | 3 | 0 | 3 |
| PRPF4B | TPP2 | 0.708978 | 4 | 0 | 4 |
| PRPF4B | ATG14 | 0.708156 | 3 | 0 | 3 |
| PRPF4B | MCPH1 | 0.707177 | 3 | 0 | 3 |
| PRPF4B | INSIG1 | 0.704674 | 3 | 0 | 3 |
For details and further investigation, click here
