DDX3X

 

Full name: DEAD-box helicase 3 X-linked Alias Symbol: DBX|HLP2|DDX14
Type: protein-coding gene Cytoband: Xp11.4
Entrez ID: 1654 HGNC ID: HGNC:2745 Ensembl Gene: ENSG00000215301 OMIM ID: 300160
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 151/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

DDX3X involved pathways:

KEGG pathway Description View
hsa04622RIG-I-like receptor signaling pathway
hsa05161Hepatitis B

 

Expression of DDX3X:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DDX3X 1654 201210_at 0.1370 0.5986
GSE20347 DDX3X 1654 201210_at -0.2636 0.0225
GSE23400 DDX3X 1654 201210_at -0.2469 0.0013
GSE26886 DDX3X 1654 201210_at -1.4334 0.0000
GSE29001 DDX3X 1654 201210_at -0.4153 0.1139
GSE38129 DDX3X 1654 201210_at -0.2774 0.0030
GSE45670 DDX3X 1654 201210_at -0.1854 0.1842
GSE53622 DDX3X 1654 83072 -0.3919 0.0000
GSE53624 DDX3X 1654 9015 -0.5878 0.0000
GSE63941 DDX3X 1654 201210_at -0.5932 0.0725
GSE77861 DDX3X 1654 201210_at -0.1958 0.3673
GSE97050 DDX3X 1654 A_24_P126060 -0.0992 0.7108
SRP007169 DDX3X 1654 RNAseq -0.1570 0.6839
SRP008496 DDX3X 1654 RNAseq -0.3326 0.2477
SRP064894 DDX3X 1654 RNAseq -0.6777 0.0060
SRP133303 DDX3X 1654 RNAseq -0.2502 0.1850
SRP159526 DDX3X 1654 RNAseq -0.5687 0.0201
SRP193095 DDX3X 1654 RNAseq -0.4204 0.0000
SRP219564 DDX3X 1654 RNAseq -0.5026 0.1134
TCGA DDX3X 1654 RNAseq -0.1311 0.0006

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by DDX3X expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DDX3X:

 

No record found for this gene.

 

Somatic mutations of DDX3X:

 

Generating mutation plots.

 

Highly correlated genes for DDX3X:

 

Showing top 20/629 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DDX3XSLC12A60.790531303
DDX3XNDUFA100.77043303
DDX3XESYT20.757969303
DDX3XCHUK0.728021303
DDX3XAKT1S10.725673303
DDX3XC5orf510.704825403
DDX3XBMX0.699435303
DDX3XTHAP10.699264303
DDX3XHNRNPH10.698195303
DDX3XSAP30L0.69421303
DDX3XHMGCL0.691989404
DDX3XPRKAG10.687072403
DDX3XNDUFS10.685016403
DDX3XUBR40.679747303
DDX3XTXNDC160.674652303
DDX3XFAHD10.672563303
DDX3XXRN10.671506303
DDX3XPPP2R5E0.670259303
DDX3XGBA20.666756303
DDX3XCNST0.663157303

For details and further investigation, click here