| Full name: chloride voltage-gated channel 3 | Alias Symbol: CLC3|ClC-3 | ||
| Type: protein-coding gene | Cytoband: 4q33 | ||
| Entrez ID: 1182 | HGNC ID: HGNC:2021 | Ensembl Gene: ENSG00000109572 | OMIM ID: 600580 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CLCN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLCN3 | 1182 | 201734_at | -0.2810 | 0.7725 | |
| GSE20347 | CLCN3 | 1182 | 201734_at | -1.1947 | 0.0000 | |
| GSE23400 | CLCN3 | 1182 | 201734_at | -0.8271 | 0.0000 | |
| GSE26886 | CLCN3 | 1182 | 201734_at | -1.1254 | 0.0000 | |
| GSE29001 | CLCN3 | 1182 | 201734_at | -0.9362 | 0.0004 | |
| GSE38129 | CLCN3 | 1182 | 201734_at | -0.7485 | 0.0003 | |
| GSE45670 | CLCN3 | 1182 | 201734_at | -0.3121 | 0.1423 | |
| GSE53622 | CLCN3 | 1182 | 24533 | -1.1538 | 0.0000 | |
| GSE53624 | CLCN3 | 1182 | 24533 | -1.3619 | 0.0000 | |
| GSE63941 | CLCN3 | 1182 | 201735_s_at | -0.2667 | 0.6214 | |
| GSE77861 | CLCN3 | 1182 | 201735_s_at | -0.6288 | 0.1089 | |
| GSE97050 | CLCN3 | A_21_P0013622 | 0.1402 | 0.5888 | ||
| SRP007169 | CLCN3 | 1182 | RNAseq | -2.1085 | 0.0000 | |
| SRP008496 | CLCN3 | 1182 | RNAseq | -1.8641 | 0.0000 | |
| SRP064894 | CLCN3 | 1182 | RNAseq | -1.4390 | 0.0000 | |
| SRP133303 | CLCN3 | 1182 | RNAseq | -0.4531 | 0.0093 | |
| SRP159526 | CLCN3 | 1182 | RNAseq | -0.7221 | 0.0082 | |
| SRP193095 | CLCN3 | 1182 | RNAseq | -1.1296 | 0.0000 | |
| SRP219564 | CLCN3 | 1182 | RNAseq | -1.3394 | 0.0089 | |
| TCGA | CLCN3 | 1182 | RNAseq | -0.1915 | 0.0018 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by CLCN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLCN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLCN3 | 1182 | 2 | 11 | 17 | |
| GSE20123 | CLCN3 | 1182 | 2 | 11 | 17 | |
| GSE43470 | CLCN3 | 1182 | 0 | 13 | 30 | |
| GSE46452 | CLCN3 | 1182 | 1 | 36 | 22 | |
| GSE47630 | CLCN3 | 1182 | 0 | 22 | 18 | |
| GSE54993 | CLCN3 | 1182 | 10 | 0 | 60 | |
| GSE54994 | CLCN3 | 1182 | 1 | 13 | 39 | |
| GSE60625 | CLCN3 | 1182 | 0 | 0 | 11 | |
| GSE74703 | CLCN3 | 1182 | 0 | 11 | 25 | |
| GSE74704 | CLCN3 | 1182 | 1 | 5 | 14 | |
| TCGA | CLCN3 | 1182 | 11 | 34 | 51 |
Total number of gains: 28; Total number of losses: 156; Total Number of normals: 304.
Somatic mutations of CLCN3:
Generating mutation plots.
Highly correlated genes for CLCN3:
Showing top 20/1615 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLCN3 | CMTR2 | 0.817744 | 3 | 0 | 3 |
| CLCN3 | SLC10A5 | 0.793091 | 3 | 0 | 3 |
| CLCN3 | CA13 | 0.775032 | 3 | 0 | 3 |
| CLCN3 | TIAM1 | 0.765178 | 11 | 0 | 11 |
| CLCN3 | ARHGAP27 | 0.760576 | 7 | 0 | 7 |
| CLCN3 | BLNK | 0.760249 | 11 | 0 | 11 |
| CLCN3 | UBL3 | 0.757876 | 10 | 0 | 10 |
| CLCN3 | ATP10B | 0.75544 | 10 | 0 | 10 |
| CLCN3 | SLC16A6 | 0.754 | 11 | 0 | 11 |
| CLCN3 | MLKL | 0.752256 | 3 | 0 | 3 |
| CLCN3 | VPS4B | 0.74902 | 12 | 0 | 11 |
| CLCN3 | USP6NL | 0.747146 | 12 | 0 | 11 |
| CLCN3 | GRHL1 | 0.744856 | 8 | 0 | 8 |
| CLCN3 | LTA4H | 0.744841 | 3 | 0 | 3 |
| CLCN3 | SH3PXD2A-AS1 | 0.744712 | 3 | 0 | 3 |
| CLCN3 | HPGD | 0.742726 | 10 | 0 | 10 |
| CLCN3 | BSPRY | 0.741187 | 10 | 0 | 10 |
| CLCN3 | MORN3 | 0.739866 | 3 | 0 | 3 |
| CLCN3 | SPINK5 | 0.738841 | 10 | 0 | 9 |
| CLCN3 | ZDHHC13 | 0.738449 | 12 | 0 | 11 |
For details and further investigation, click here
