| Full name: leukotriene A4 hydrolase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q23.1 | ||
| Entrez ID: 4048 | HGNC ID: HGNC:6710 | Ensembl Gene: ENSG00000111144 | OMIM ID: 151570 |
| Drug and gene relationship at DGIdb | |||
Expression of LTA4H:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | LTA4H | 4048 | 116862 | -0.9618 | 0.0000 | |
| GSE53624 | LTA4H | 4048 | 4987 | -1.2881 | 0.0000 | |
| GSE97050 | LTA4H | 4048 | A_33_P3410093 | 0.2578 | 0.3317 | |
| SRP007169 | LTA4H | 4048 | RNAseq | -1.8333 | 0.0000 | |
| SRP008496 | LTA4H | 4048 | RNAseq | -2.0545 | 0.0000 | |
| SRP064894 | LTA4H | 4048 | RNAseq | -0.9762 | 0.0000 | |
| SRP133303 | LTA4H | 4048 | RNAseq | -1.2366 | 0.0000 | |
| SRP159526 | LTA4H | 4048 | RNAseq | -1.4241 | 0.0000 | |
| SRP193095 | LTA4H | 4048 | RNAseq | -1.4217 | 0.0000 | |
| SRP219564 | LTA4H | 4048 | RNAseq | -1.3882 | 0.0000 | |
| TCGA | LTA4H | 4048 | RNAseq | -0.0176 | 0.7392 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by LTA4H expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LTA4H:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LTA4H | 4048 | 3 | 1 | 26 | |
| GSE20123 | LTA4H | 4048 | 3 | 1 | 26 | |
| GSE43470 | LTA4H | 4048 | 3 | 0 | 40 | |
| GSE46452 | LTA4H | 4048 | 9 | 1 | 49 | |
| GSE47630 | LTA4H | 4048 | 9 | 1 | 30 | |
| GSE54993 | LTA4H | 4048 | 0 | 5 | 65 | |
| GSE54994 | LTA4H | 4048 | 4 | 1 | 48 | |
| GSE60625 | LTA4H | 4048 | 0 | 0 | 11 | |
| GSE74703 | LTA4H | 4048 | 3 | 0 | 33 | |
| GSE74704 | LTA4H | 4048 | 1 | 1 | 18 | |
| TCGA | LTA4H | 4048 | 18 | 10 | 68 |
Total number of gains: 53; Total number of losses: 21; Total Number of normals: 414.
Somatic mutations of LTA4H:
Generating mutation plots.
Highly correlated genes for LTA4H:
Showing top 20/416 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LTA4H | RAB25 | 0.79919 | 3 | 0 | 3 |
| LTA4H | TGM1 | 0.796975 | 3 | 0 | 3 |
| LTA4H | ZDHHC13 | 0.796308 | 3 | 0 | 3 |
| LTA4H | YOD1 | 0.793993 | 3 | 0 | 3 |
| LTA4H | TST | 0.786946 | 3 | 0 | 3 |
| LTA4H | ASPG | 0.785219 | 3 | 0 | 3 |
| LTA4H | ARHGAP27 | 0.782404 | 3 | 0 | 3 |
| LTA4H | THSD4 | 0.774633 | 3 | 0 | 3 |
| LTA4H | SYTL1 | 0.768821 | 3 | 0 | 3 |
| LTA4H | ATG9B | 0.768275 | 3 | 0 | 3 |
| LTA4H | CDA | 0.7663 | 3 | 0 | 3 |
| LTA4H | NIPAL1 | 0.766113 | 3 | 0 | 3 |
| LTA4H | DNASE1L3 | 0.764629 | 3 | 0 | 3 |
| LTA4H | NT5C2 | 0.762602 | 3 | 0 | 3 |
| LTA4H | MIOS | 0.760494 | 3 | 0 | 3 |
| LTA4H | TMEM40 | 0.760277 | 3 | 0 | 3 |
| LTA4H | TPD52L1 | 0.759621 | 3 | 0 | 3 |
| LTA4H | TTC9 | 0.759171 | 3 | 0 | 3 |
| LTA4H | HSD17B4 | 0.758642 | 3 | 0 | 3 |
| LTA4H | NAGK | 0.756307 | 3 | 0 | 3 |
For details and further investigation, click here
