| Full name: B cell linker | Alias Symbol: SLP65|Ly57|SLP-65|BLNK-s|BASH|bca | ||
| Type: protein-coding gene | Cytoband: 10q24.1 | ||
| Entrez ID: 29760 | HGNC ID: HGNC:14211 | Ensembl Gene: ENSG00000095585 | OMIM ID: 604515 |
| Drug and gene relationship at DGIdb | |||
BLNK involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04380 | Osteoclast differentiation | |
| hsa04662 | B cell receptor signaling pathway |
Expression of BLNK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BLNK | 29760 | 207655_s_at | -1.5905 | 0.1452 | |
| GSE20347 | BLNK | 29760 | 207655_s_at | -3.4398 | 0.0000 | |
| GSE23400 | BLNK | 29760 | 207655_s_at | -2.4589 | 0.0000 | |
| GSE26886 | BLNK | 29760 | 207655_s_at | -3.8365 | 0.0000 | |
| GSE29001 | BLNK | 29760 | 207655_s_at | -2.7753 | 0.0000 | |
| GSE38129 | BLNK | 29760 | 207655_s_at | -2.3919 | 0.0000 | |
| GSE45670 | BLNK | 29760 | 207655_s_at | -1.0710 | 0.0236 | |
| GSE53622 | BLNK | 29760 | 10264 | -2.1288 | 0.0000 | |
| GSE53624 | BLNK | 29760 | 10264 | -2.9003 | 0.0000 | |
| GSE63941 | BLNK | 29760 | 207655_s_at | 1.9534 | 0.1559 | |
| GSE77861 | BLNK | 29760 | 207655_s_at | -2.7825 | 0.0006 | |
| GSE97050 | BLNK | 29760 | A_24_P64344 | -0.7573 | 0.4291 | |
| SRP007169 | BLNK | 29760 | RNAseq | -4.7355 | 0.0000 | |
| SRP008496 | BLNK | 29760 | RNAseq | -4.2882 | 0.0000 | |
| SRP064894 | BLNK | 29760 | RNAseq | -3.0455 | 0.0000 | |
| SRP133303 | BLNK | 29760 | RNAseq | -2.2729 | 0.0000 | |
| SRP159526 | BLNK | 29760 | RNAseq | -3.4586 | 0.0000 | |
| SRP193095 | BLNK | 29760 | RNAseq | -2.2767 | 0.0000 | |
| SRP219564 | BLNK | 29760 | RNAseq | -2.6177 | 0.0020 | |
| TCGA | BLNK | 29760 | RNAseq | -0.3465 | 0.1004 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by BLNK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BLNK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BLNK | 29760 | 0 | 8 | 22 | |
| GSE20123 | BLNK | 29760 | 0 | 7 | 23 | |
| GSE43470 | BLNK | 29760 | 0 | 7 | 36 | |
| GSE46452 | BLNK | 29760 | 0 | 11 | 48 | |
| GSE47630 | BLNK | 29760 | 2 | 14 | 24 | |
| GSE54993 | BLNK | 29760 | 7 | 0 | 63 | |
| GSE54994 | BLNK | 29760 | 2 | 10 | 41 | |
| GSE60625 | BLNK | 29760 | 0 | 0 | 11 | |
| GSE74703 | BLNK | 29760 | 0 | 5 | 31 | |
| GSE74704 | BLNK | 29760 | 0 | 4 | 16 | |
| TCGA | BLNK | 29760 | 5 | 28 | 63 |
Total number of gains: 16; Total number of losses: 94; Total Number of normals: 378.
Somatic mutations of BLNK:
Generating mutation plots.
Highly correlated genes for BLNK:
Showing top 20/1742 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BLNK | SCNN1B | 0.884227 | 10 | 0 | 10 |
| BLNK | CCNG2 | 0.859484 | 11 | 0 | 11 |
| BLNK | UBL3 | 0.855682 | 10 | 0 | 10 |
| BLNK | TTC9 | 0.855126 | 11 | 0 | 11 |
| BLNK | RANBP9 | 0.851689 | 11 | 0 | 11 |
| BLNK | SPINK7 | 0.849494 | 6 | 0 | 6 |
| BLNK | ECM1 | 0.848919 | 10 | 0 | 10 |
| BLNK | NAGK | 0.848517 | 11 | 0 | 11 |
| BLNK | ENDOU | 0.845735 | 11 | 0 | 11 |
| BLNK | GYS2 | 0.845121 | 10 | 0 | 10 |
| BLNK | NT5C2 | 0.844257 | 11 | 0 | 11 |
| BLNK | FAM214A | 0.837481 | 6 | 0 | 6 |
| BLNK | USP6NL | 0.833462 | 11 | 0 | 11 |
| BLNK | FCHO2 | 0.829887 | 7 | 0 | 7 |
| BLNK | EPB41L3 | 0.828947 | 11 | 0 | 11 |
| BLNK | CLCA4 | 0.827121 | 11 | 0 | 11 |
| BLNK | SMAGP | 0.826233 | 11 | 0 | 10 |
| BLNK | ESPL1 | 0.826159 | 10 | 0 | 10 |
| BLNK | KLB | 0.824834 | 6 | 0 | 6 |
| BLNK | TIAM1 | 0.824431 | 11 | 0 | 11 |
For details and further investigation, click here
