| Full name: vacuolar protein sorting 4 homolog B | Alias Symbol: VPS4-2|SKD1B | ||
| Type: protein-coding gene | Cytoband: 18q21.33 | ||
| Entrez ID: 9525 | HGNC ID: HGNC:10895 | Ensembl Gene: ENSG00000119541 | OMIM ID: 609983 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of VPS4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS4B | 9525 | 218171_at | -0.7730 | 0.2798 | |
| GSE20347 | VPS4B | 9525 | 218171_at | -1.3808 | 0.0000 | |
| GSE23400 | VPS4B | 9525 | 218171_at | -1.0686 | 0.0000 | |
| GSE26886 | VPS4B | 9525 | 218171_at | -2.4510 | 0.0000 | |
| GSE29001 | VPS4B | 9525 | 218171_at | -0.8923 | 0.0007 | |
| GSE38129 | VPS4B | 9525 | 218171_at | -0.9502 | 0.0000 | |
| GSE45670 | VPS4B | 9525 | 218171_at | -0.3790 | 0.1041 | |
| GSE53622 | VPS4B | 9525 | 77121 | -1.4225 | 0.0000 | |
| GSE53624 | VPS4B | 9525 | 77121 | -1.6518 | 0.0000 | |
| GSE63941 | VPS4B | 9525 | 218171_at | -0.4930 | 0.2677 | |
| GSE77861 | VPS4B | 9525 | 218171_at | -1.0139 | 0.0293 | |
| GSE97050 | VPS4B | 9525 | A_24_P322369 | -0.5840 | 0.1965 | |
| SRP007169 | VPS4B | 9525 | RNAseq | -2.5379 | 0.0000 | |
| SRP008496 | VPS4B | 9525 | RNAseq | -2.4872 | 0.0000 | |
| SRP064894 | VPS4B | 9525 | RNAseq | -1.8406 | 0.0000 | |
| SRP133303 | VPS4B | 9525 | RNAseq | -1.1237 | 0.0000 | |
| SRP159526 | VPS4B | 9525 | RNAseq | -1.4495 | 0.0029 | |
| SRP193095 | VPS4B | 9525 | RNAseq | -1.5389 | 0.0000 | |
| SRP219564 | VPS4B | 9525 | RNAseq | -2.1044 | 0.0001 | |
| TCGA | VPS4B | 9525 | RNAseq | -0.0396 | 0.5024 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by VPS4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS4B | 9525 | 1 | 9 | 20 | |
| GSE20123 | VPS4B | 9525 | 1 | 9 | 20 | |
| GSE43470 | VPS4B | 9525 | 0 | 7 | 36 | |
| GSE46452 | VPS4B | 9525 | 1 | 26 | 32 | |
| GSE47630 | VPS4B | 9525 | 5 | 21 | 14 | |
| GSE54993 | VPS4B | 9525 | 9 | 0 | 61 | |
| GSE54994 | VPS4B | 9525 | 1 | 18 | 34 | |
| GSE60625 | VPS4B | 9525 | 0 | 4 | 7 | |
| GSE74703 | VPS4B | 9525 | 0 | 7 | 29 | |
| GSE74704 | VPS4B | 9525 | 1 | 6 | 13 | |
| TCGA | VPS4B | 9525 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of VPS4B:
Generating mutation plots.
Highly correlated genes for VPS4B:
Showing top 20/1961 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS4B | VSIG10L | 0.841038 | 6 | 0 | 6 |
| VPS4B | GRPEL2 | 0.839423 | 7 | 0 | 7 |
| VPS4B | TMPRSS11E | 0.836667 | 10 | 0 | 10 |
| VPS4B | SASH1 | 0.836509 | 11 | 0 | 11 |
| VPS4B | ECM1 | 0.836356 | 10 | 0 | 10 |
| VPS4B | SCEL | 0.833764 | 11 | 0 | 10 |
| VPS4B | RANBP9 | 0.831114 | 12 | 0 | 12 |
| VPS4B | RAB11A | 0.830898 | 11 | 0 | 11 |
| VPS4B | CRCT1 | 0.829506 | 10 | 0 | 10 |
| VPS4B | SCNN1B | 0.829471 | 10 | 0 | 10 |
| VPS4B | NT5C2 | 0.826968 | 11 | 0 | 11 |
| VPS4B | IL36A | 0.82634 | 10 | 0 | 10 |
| VPS4B | EVPL | 0.82599 | 10 | 0 | 10 |
| VPS4B | CA13 | 0.824091 | 3 | 0 | 3 |
| VPS4B | USP6NL | 0.821764 | 12 | 0 | 11 |
| VPS4B | IMPACT | 0.820838 | 3 | 0 | 3 |
| VPS4B | TTC9 | 0.819171 | 11 | 0 | 11 |
| VPS4B | PLEKHA7 | 0.818368 | 7 | 0 | 7 |
| VPS4B | ENDOU | 0.817557 | 11 | 0 | 11 |
| VPS4B | EMP1 | 0.817065 | 11 | 0 | 11 |
For details and further investigation, click here
