| Full name: grainyhead like transcription factor 1 | Alias Symbol: LBP-32|MGR | ||
| Type: protein-coding gene | Cytoband: 2p25.1 | ||
| Entrez ID: 29841 | HGNC ID: HGNC:17923 | Ensembl Gene: ENSG00000134317 | OMIM ID: 609786 |
| Drug and gene relationship at DGIdb | |||
Expression of GRHL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRHL1 | 29841 | 222830_at | -1.1473 | 0.3467 | |
| GSE26886 | GRHL1 | 29841 | 222830_at | -3.4501 | 0.0000 | |
| GSE45670 | GRHL1 | 29841 | 222830_at | -0.4836 | 0.0529 | |
| GSE53622 | GRHL1 | 29841 | 110949 | -1.4209 | 0.0000 | |
| GSE53624 | GRHL1 | 29841 | 22961 | -2.2828 | 0.0000 | |
| GSE63941 | GRHL1 | 29841 | 222830_at | 3.5157 | 0.0025 | |
| GSE77861 | GRHL1 | 29841 | 222830_at | -1.3299 | 0.0197 | |
| GSE97050 | GRHL1 | 29841 | A_33_P3423791 | -0.2293 | 0.7425 | |
| SRP007169 | GRHL1 | 29841 | RNAseq | -3.2221 | 0.0000 | |
| SRP008496 | GRHL1 | 29841 | RNAseq | -3.2654 | 0.0000 | |
| SRP064894 | GRHL1 | 29841 | RNAseq | -2.5874 | 0.0000 | |
| SRP133303 | GRHL1 | 29841 | RNAseq | -2.1574 | 0.0000 | |
| SRP159526 | GRHL1 | 29841 | RNAseq | -2.4449 | 0.0000 | |
| SRP193095 | GRHL1 | 29841 | RNAseq | -2.2884 | 0.0000 | |
| SRP219564 | GRHL1 | 29841 | RNAseq | -3.9117 | 0.0000 | |
| TCGA | GRHL1 | 29841 | RNAseq | 0.4352 | 0.0056 |
Upregulated datasets: 1; Downregulated datasets: 11.
Survival by GRHL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRHL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRHL1 | 29841 | 11 | 2 | 17 | |
| GSE20123 | GRHL1 | 29841 | 11 | 2 | 17 | |
| GSE43470 | GRHL1 | 29841 | 4 | 1 | 38 | |
| GSE46452 | GRHL1 | 29841 | 3 | 4 | 52 | |
| GSE47630 | GRHL1 | 29841 | 7 | 0 | 33 | |
| GSE54993 | GRHL1 | 29841 | 0 | 7 | 63 | |
| GSE54994 | GRHL1 | 29841 | 11 | 0 | 42 | |
| GSE60625 | GRHL1 | 29841 | 0 | 3 | 8 | |
| GSE74703 | GRHL1 | 29841 | 3 | 0 | 33 | |
| GSE74704 | GRHL1 | 29841 | 9 | 1 | 10 | |
| TCGA | GRHL1 | 29841 | 34 | 5 | 57 |
Total number of gains: 93; Total number of losses: 25; Total Number of normals: 370.
Somatic mutations of GRHL1:
Generating mutation plots.
Highly correlated genes for GRHL1:
Showing top 20/1312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRHL1 | TMPRSS11E | 0.83593 | 7 | 0 | 7 |
| GRHL1 | CNFN | 0.835255 | 8 | 0 | 8 |
| GRHL1 | CLIC3 | 0.829163 | 6 | 0 | 6 |
| GRHL1 | GRHL3 | 0.827145 | 9 | 0 | 9 |
| GRHL1 | TGM1 | 0.826636 | 8 | 0 | 8 |
| GRHL1 | CSTB | 0.811013 | 8 | 0 | 8 |
| GRHL1 | ZNF185 | 0.810915 | 8 | 0 | 8 |
| GRHL1 | ARHGAP32 | 0.809593 | 7 | 0 | 7 |
| GRHL1 | PPL | 0.804715 | 9 | 0 | 9 |
| GRHL1 | BNIPL | 0.803934 | 8 | 0 | 7 |
| GRHL1 | NIPAL1 | 0.803124 | 3 | 0 | 3 |
| GRHL1 | EPHX3 | 0.800339 | 7 | 0 | 7 |
| GRHL1 | VSIG10L | 0.79913 | 7 | 0 | 7 |
| GRHL1 | TMEM45B | 0.798258 | 8 | 0 | 8 |
| GRHL1 | KLK13 | 0.797947 | 8 | 0 | 8 |
| GRHL1 | IKZF2 | 0.797799 | 7 | 0 | 7 |
| GRHL1 | CRCT1 | 0.797479 | 8 | 0 | 8 |
| GRHL1 | CHP1 | 0.795346 | 6 | 0 | 6 |
| GRHL1 | RAB25 | 0.795234 | 9 | 0 | 9 |
| GRHL1 | TMEM40 | 0.793821 | 9 | 0 | 8 |
For details and further investigation, click here
