| Full name: serine peptidase inhibitor, Kazal type 5 | Alias Symbol: VAKTI|LEKTI|LETKI|NETS|NS|FLJ21544|FLJ97536|FLJ97596|FLJ99794|DKFZp686K19184 | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 11005 | HGNC ID: HGNC:15464 | Ensembl Gene: ENSG00000133710 | OMIM ID: 605010 |
| Drug and gene relationship at DGIdb | |||
Expression of SPINK5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPINK5 | 11005 | 205185_at | -4.5605 | 0.0204 | |
| GSE20347 | SPINK5 | 11005 | 205185_at | -4.9649 | 0.0000 | |
| GSE23400 | SPINK5 | 11005 | 205185_at | -3.5300 | 0.0000 | |
| GSE26886 | SPINK5 | 11005 | 205185_at | -6.6198 | 0.0000 | |
| GSE29001 | SPINK5 | 11005 | 205185_at | -4.5876 | 0.0000 | |
| GSE38129 | SPINK5 | 11005 | 205185_at | -3.5505 | 0.0000 | |
| GSE45670 | SPINK5 | 11005 | 205185_at | -1.7360 | 0.0190 | |
| GSE53622 | SPINK5 | 11005 | 23470 | -3.9472 | 0.0000 | |
| GSE53624 | SPINK5 | 11005 | 23470 | -4.3356 | 0.0000 | |
| GSE63941 | SPINK5 | 11005 | 205185_at | 1.8077 | 0.0776 | |
| GSE77861 | SPINK5 | 11005 | 205185_at | -3.3461 | 0.0173 | |
| GSE97050 | SPINK5 | 11005 | A_33_P3391126 | -2.8448 | 0.1120 | |
| SRP007169 | SPINK5 | 11005 | RNAseq | -7.8251 | 0.0000 | |
| SRP008496 | SPINK5 | 11005 | RNAseq | -6.5429 | 0.0000 | |
| SRP064894 | SPINK5 | 11005 | RNAseq | -5.7528 | 0.0000 | |
| SRP133303 | SPINK5 | 11005 | RNAseq | -6.2076 | 0.0000 | |
| SRP159526 | SPINK5 | 11005 | RNAseq | -5.9794 | 0.0000 | |
| SRP193095 | SPINK5 | 11005 | RNAseq | -5.2416 | 0.0000 | |
| SRP219564 | SPINK5 | 11005 | RNAseq | -5.2276 | 0.0001 | |
| TCGA | SPINK5 | 11005 | RNAseq | 0.0139 | 0.9626 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by SPINK5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPINK5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPINK5 | 11005 | 1 | 12 | 17 | |
| GSE20123 | SPINK5 | 11005 | 1 | 13 | 16 | |
| GSE43470 | SPINK5 | 11005 | 2 | 9 | 32 | |
| GSE46452 | SPINK5 | 11005 | 0 | 27 | 32 | |
| GSE47630 | SPINK5 | 11005 | 0 | 20 | 20 | |
| GSE54993 | SPINK5 | 11005 | 9 | 1 | 60 | |
| GSE54994 | SPINK5 | 11005 | 2 | 15 | 36 | |
| GSE60625 | SPINK5 | 11005 | 0 | 0 | 11 | |
| GSE74703 | SPINK5 | 11005 | 2 | 7 | 27 | |
| GSE74704 | SPINK5 | 11005 | 1 | 8 | 11 | |
| TCGA | SPINK5 | 11005 | 5 | 38 | 53 |
Total number of gains: 23; Total number of losses: 150; Total Number of normals: 315.
Somatic mutations of SPINK5:
Generating mutation plots.
Highly correlated genes for SPINK5:
Showing top 20/1413 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPINK5 | CYSRT1 | 0.955438 | 6 | 0 | 6 |
| SPINK5 | SCEL | 0.944041 | 12 | 0 | 12 |
| SPINK5 | CRNN | 0.936286 | 12 | 0 | 12 |
| SPINK5 | TMPRSS11B | 0.933219 | 8 | 0 | 8 |
| SPINK5 | SLURP1 | 0.922131 | 12 | 0 | 12 |
| SPINK5 | VSIG10L | 0.916016 | 7 | 0 | 7 |
| SPINK5 | PRSS27 | 0.909767 | 8 | 0 | 8 |
| SPINK5 | CLIC3 | 0.900561 | 10 | 0 | 10 |
| SPINK5 | KLK13 | 0.897665 | 12 | 0 | 12 |
| SPINK5 | CAPN14 | 0.897461 | 7 | 0 | 7 |
| SPINK5 | CLCA4 | 0.890223 | 13 | 0 | 12 |
| SPINK5 | NCCRP1 | 0.886671 | 4 | 0 | 4 |
| SPINK5 | KRT4 | 0.882447 | 12 | 0 | 12 |
| SPINK5 | CNFN | 0.878897 | 8 | 0 | 8 |
| SPINK5 | MAL | 0.877191 | 13 | 0 | 12 |
| SPINK5 | EMP1 | 0.876437 | 12 | 0 | 11 |
| SPINK5 | CXCR2 | 0.875639 | 10 | 0 | 10 |
| SPINK5 | KRT78 | 0.875 | 8 | 0 | 8 |
| SPINK5 | NCR1 | 0.874995 | 3 | 0 | 3 |
| SPINK5 | LYNX1 | 0.873375 | 8 | 0 | 8 |
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