| Full name: chloride intracellular channel 6 | Alias Symbol: CLIC5 | ||
| Type: protein-coding gene | Cytoband: 21q22.12 | ||
| Entrez ID: 54102 | HGNC ID: HGNC:2065 | Ensembl Gene: ENSG00000159212 | OMIM ID: 615321 |
| Drug and gene relationship at DGIdb | |||
Expression of CLIC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLIC6 | 54102 | 227742_at | 1.2227 | 0.5346 | |
| GSE26886 | CLIC6 | 54102 | 227742_at | 0.4796 | 0.4983 | |
| GSE45670 | CLIC6 | 54102 | 227742_at | 0.1867 | 0.7817 | |
| GSE53622 | CLIC6 | 54102 | 92363 | 0.1854 | 0.5768 | |
| GSE53624 | CLIC6 | 54102 | 92363 | -0.0578 | 0.8327 | |
| GSE63941 | CLIC6 | 54102 | 227742_at | -2.3202 | 0.0000 | |
| GSE77861 | CLIC6 | 54102 | 227742_at | 0.2225 | 0.7040 | |
| GSE97050 | CLIC6 | 54102 | A_23_P385067 | 0.3361 | 0.4471 | |
| SRP064894 | CLIC6 | 54102 | RNAseq | -0.1301 | 0.7380 | |
| SRP133303 | CLIC6 | 54102 | RNAseq | 0.7621 | 0.0737 | |
| SRP159526 | CLIC6 | 54102 | RNAseq | 1.7687 | 0.0128 | |
| SRP193095 | CLIC6 | 54102 | RNAseq | 1.1931 | 0.0081 | |
| SRP219564 | CLIC6 | 54102 | RNAseq | 0.7989 | 0.1815 | |
| TCGA | CLIC6 | 54102 | RNAseq | -1.6060 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by CLIC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLIC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLIC6 | 54102 | 2 | 8 | 20 | |
| GSE20123 | CLIC6 | 54102 | 2 | 9 | 19 | |
| GSE43470 | CLIC6 | 54102 | 1 | 11 | 31 | |
| GSE46452 | CLIC6 | 54102 | 1 | 21 | 37 | |
| GSE47630 | CLIC6 | 54102 | 6 | 17 | 17 | |
| GSE54993 | CLIC6 | 54102 | 9 | 1 | 60 | |
| GSE54994 | CLIC6 | 54102 | 1 | 9 | 43 | |
| GSE60625 | CLIC6 | 54102 | 0 | 0 | 11 | |
| GSE74703 | CLIC6 | 54102 | 1 | 8 | 27 | |
| GSE74704 | CLIC6 | 54102 | 1 | 5 | 14 | |
| TCGA | CLIC6 | 54102 | 8 | 38 | 50 |
Total number of gains: 32; Total number of losses: 127; Total Number of normals: 329.
Somatic mutations of CLIC6:
Generating mutation plots.
Highly correlated genes for CLIC6:
Showing top 20/243 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLIC6 | ALG10 | 0.726492 | 3 | 0 | 3 |
| CLIC6 | ZNF578 | 0.725984 | 3 | 0 | 3 |
| CLIC6 | TRDN | 0.704035 | 4 | 0 | 3 |
| CLIC6 | SGCG | 0.698369 | 3 | 0 | 3 |
| CLIC6 | LINC00865 | 0.6941 | 4 | 0 | 4 |
| CLIC6 | PIF1 | 0.688811 | 3 | 0 | 3 |
| CLIC6 | SUFU | 0.686557 | 3 | 0 | 3 |
| CLIC6 | RBM4B | 0.682848 | 3 | 0 | 3 |
| CLIC6 | SYNPO2 | 0.680757 | 3 | 0 | 3 |
| CLIC6 | HIVEP1 | 0.679924 | 3 | 0 | 3 |
| CLIC6 | SLC51A | 0.676896 | 3 | 0 | 3 |
| CLIC6 | POGLUT1 | 0.670752 | 3 | 0 | 3 |
| CLIC6 | ZNF506 | 0.670693 | 3 | 0 | 3 |
| CLIC6 | OSR2 | 0.67041 | 3 | 0 | 3 |
| CLIC6 | ZNF850 | 0.668061 | 4 | 0 | 3 |
| CLIC6 | AP3M2 | 0.665671 | 4 | 0 | 3 |
| CLIC6 | DPP3 | 0.66451 | 3 | 0 | 3 |
| CLIC6 | ARHGAP28 | 0.664042 | 4 | 0 | 3 |
| CLIC6 | SMARCD2 | 0.658647 | 3 | 0 | 3 |
| CLIC6 | MEPCE | 0.65841 | 3 | 0 | 3 |
For details and further investigation, click here
