| Full name: Rho GTPase activating protein 28 | Alias Symbol: KIAA1314|FLJ10312 | ||
| Type: protein-coding gene | Cytoband: 18p11.31 | ||
| Entrez ID: 79822 | HGNC ID: HGNC:25509 | Ensembl Gene: ENSG00000088756 | OMIM ID: 610592 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGAP28:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGAP28 | 79822 | 227911_at | -0.3111 | 0.7278 | |
| GSE20347 | ARHGAP28 | 79822 | 220381_at | 0.0528 | 0.5399 | |
| GSE23400 | ARHGAP28 | 79822 | 220381_at | -0.0026 | 0.9463 | |
| GSE26886 | ARHGAP28 | 79822 | 227911_at | 0.9147 | 0.0233 | |
| GSE29001 | ARHGAP28 | 79822 | 220381_at | -0.1313 | 0.3265 | |
| GSE38129 | ARHGAP28 | 79822 | 220381_at | 0.0233 | 0.7921 | |
| GSE45670 | ARHGAP28 | 79822 | 227911_at | -0.2003 | 0.6630 | |
| GSE53622 | ARHGAP28 | 79822 | 40121 | 0.4251 | 0.0211 | |
| GSE53624 | ARHGAP28 | 79822 | 40121 | 0.5827 | 0.0015 | |
| GSE63941 | ARHGAP28 | 79822 | 227911_at | -2.5539 | 0.0003 | |
| GSE77861 | ARHGAP28 | 79822 | 220382_s_at | -0.0230 | 0.8893 | |
| GSE97050 | ARHGAP28 | 79822 | A_23_P130359 | 0.4511 | 0.2159 | |
| SRP007169 | ARHGAP28 | 79822 | RNAseq | 3.3042 | 0.0004 | |
| SRP008496 | ARHGAP28 | 79822 | RNAseq | 2.3144 | 0.0103 | |
| SRP064894 | ARHGAP28 | 79822 | RNAseq | 0.6383 | 0.1491 | |
| SRP133303 | ARHGAP28 | 79822 | RNAseq | 0.5886 | 0.1976 | |
| SRP159526 | ARHGAP28 | 79822 | RNAseq | 1.4228 | 0.0050 | |
| SRP193095 | ARHGAP28 | 79822 | RNAseq | 0.6965 | 0.0023 | |
| SRP219564 | ARHGAP28 | 79822 | RNAseq | 1.3682 | 0.0937 | |
| TCGA | ARHGAP28 | 79822 | RNAseq | 0.3624 | 0.0732 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by ARHGAP28 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGAP28:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGAP28 | 79822 | 7 | 3 | 20 | |
| GSE20123 | ARHGAP28 | 79822 | 7 | 3 | 20 | |
| GSE43470 | ARHGAP28 | 79822 | 4 | 5 | 34 | |
| GSE46452 | ARHGAP28 | 79822 | 3 | 21 | 35 | |
| GSE47630 | ARHGAP28 | 79822 | 7 | 17 | 16 | |
| GSE54993 | ARHGAP28 | 79822 | 6 | 3 | 61 | |
| GSE54994 | ARHGAP28 | 79822 | 9 | 8 | 36 | |
| GSE60625 | ARHGAP28 | 79822 | 0 | 4 | 7 | |
| GSE74703 | ARHGAP28 | 79822 | 3 | 3 | 30 | |
| GSE74704 | ARHGAP28 | 79822 | 5 | 2 | 13 | |
| TCGA | ARHGAP28 | 79822 | 33 | 20 | 43 |
Total number of gains: 84; Total number of losses: 89; Total Number of normals: 315.
Somatic mutations of ARHGAP28:
Generating mutation plots.
Highly correlated genes for ARHGAP28:
Showing top 20/80 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGAP28 | LEF1 | 0.734991 | 3 | 0 | 3 |
| ARHGAP28 | ARL15 | 0.688877 | 3 | 0 | 3 |
| ARHGAP28 | ZNF581 | 0.681401 | 3 | 0 | 3 |
| ARHGAP28 | CLIC6 | 0.664042 | 4 | 0 | 3 |
| ARHGAP28 | SNX12 | 0.659255 | 3 | 0 | 3 |
| ARHGAP28 | ITGA2 | 0.657163 | 4 | 0 | 3 |
| ARHGAP28 | SMG9 | 0.651151 | 3 | 0 | 3 |
| ARHGAP28 | LZTS1 | 0.643873 | 5 | 0 | 3 |
| ARHGAP28 | PI15 | 0.637299 | 3 | 0 | 3 |
| ARHGAP28 | CLEC4A | 0.636517 | 3 | 0 | 3 |
| ARHGAP28 | CD37 | 0.635588 | 3 | 0 | 3 |
| ARHGAP28 | NTRK2 | 0.629396 | 5 | 0 | 5 |
| ARHGAP28 | PCDH19 | 0.622438 | 4 | 0 | 4 |
| ARHGAP28 | STAT2 | 0.615834 | 3 | 0 | 3 |
| ARHGAP28 | TTC39C | 0.615195 | 3 | 0 | 3 |
| ARHGAP28 | NAGA | 0.610463 | 4 | 0 | 3 |
| ARHGAP28 | PARVG | 0.610223 | 3 | 0 | 3 |
| ARHGAP28 | TDRD6 | 0.609383 | 3 | 0 | 3 |
| ARHGAP28 | LRRK1 | 0.607761 | 3 | 0 | 3 |
| ARHGAP28 | SOX5 | 0.604389 | 4 | 0 | 3 |
For details and further investigation, click here
