| Full name: CDC like kinase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q33.1 | ||
| Entrez ID: 1195 | HGNC ID: HGNC:2068 | Ensembl Gene: ENSG00000013441 | OMIM ID: 601951 |
| Drug and gene relationship at DGIdb | |||
Expression of CLK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLK1 | 1195 | 214683_s_at | -0.3369 | 0.7316 | |
| GSE20347 | CLK1 | 1195 | 214683_s_at | -0.1905 | 0.4025 | |
| GSE23400 | CLK1 | 1195 | 214683_s_at | -0.1080 | 0.3231 | |
| GSE26886 | CLK1 | 1195 | 214683_s_at | -1.1266 | 0.0024 | |
| GSE29001 | CLK1 | 1195 | 214683_s_at | -0.3439 | 0.3312 | |
| GSE38129 | CLK1 | 1195 | 214683_s_at | -0.2809 | 0.1893 | |
| GSE45670 | CLK1 | 1195 | 214683_s_at | -0.0199 | 0.9314 | |
| GSE53622 | CLK1 | 1195 | 79983 | -0.0019 | 0.9828 | |
| GSE53624 | CLK1 | 1195 | 79983 | -0.2268 | 0.0000 | |
| GSE63941 | CLK1 | 1195 | 214683_s_at | -0.8018 | 0.0977 | |
| GSE77861 | CLK1 | 1195 | 214683_s_at | -0.5152 | 0.0409 | |
| GSE97050 | CLK1 | 1195 | A_23_P16817 | -0.1884 | 0.4073 | |
| SRP007169 | CLK1 | 1195 | RNAseq | -1.1184 | 0.0105 | |
| SRP008496 | CLK1 | 1195 | RNAseq | -0.9748 | 0.0002 | |
| SRP064894 | CLK1 | 1195 | RNAseq | -0.5632 | 0.0025 | |
| SRP133303 | CLK1 | 1195 | RNAseq | -0.2386 | 0.1319 | |
| SRP159526 | CLK1 | 1195 | RNAseq | -1.0141 | 0.0001 | |
| SRP193095 | CLK1 | 1195 | RNAseq | -0.5879 | 0.0000 | |
| SRP219564 | CLK1 | 1195 | RNAseq | -0.6731 | 0.0639 | |
| TCGA | CLK1 | 1195 | RNAseq | -0.1989 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CLK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLK1 | 1195 | 6 | 4 | 20 | |
| GSE20123 | CLK1 | 1195 | 6 | 4 | 20 | |
| GSE43470 | CLK1 | 1195 | 2 | 1 | 40 | |
| GSE46452 | CLK1 | 1195 | 1 | 4 | 54 | |
| GSE47630 | CLK1 | 1195 | 4 | 5 | 31 | |
| GSE54993 | CLK1 | 1195 | 0 | 3 | 67 | |
| GSE54994 | CLK1 | 1195 | 10 | 8 | 35 | |
| GSE60625 | CLK1 | 1195 | 0 | 3 | 8 | |
| GSE74703 | CLK1 | 1195 | 2 | 1 | 33 | |
| GSE74704 | CLK1 | 1195 | 3 | 2 | 15 | |
| TCGA | CLK1 | 1195 | 22 | 11 | 63 |
Total number of gains: 56; Total number of losses: 46; Total Number of normals: 386.
Somatic mutations of CLK1:
Generating mutation plots.
Highly correlated genes for CLK1:
Showing top 20/465 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLK1 | JAK2 | 0.789137 | 3 | 0 | 3 |
| CLK1 | MIER3 | 0.759869 | 3 | 0 | 3 |
| CLK1 | WLS | 0.745163 | 3 | 0 | 3 |
| CLK1 | ZNF547 | 0.736549 | 3 | 0 | 3 |
| CLK1 | TAOK3 | 0.735586 | 3 | 0 | 3 |
| CLK1 | STXBP5 | 0.729263 | 4 | 0 | 3 |
| CLK1 | ZCCHC9 | 0.725837 | 3 | 0 | 3 |
| CLK1 | KIF1B | 0.72261 | 3 | 0 | 3 |
| CLK1 | MRPL39 | 0.721234 | 3 | 0 | 3 |
| CLK1 | PAQR8 | 0.720861 | 3 | 0 | 3 |
| CLK1 | ZNF844 | 0.718696 | 3 | 0 | 3 |
| CLK1 | FBXO9 | 0.716178 | 4 | 0 | 4 |
| CLK1 | RAB18 | 0.714046 | 3 | 0 | 3 |
| CLK1 | MBLAC2 | 0.711541 | 3 | 0 | 3 |
| CLK1 | ACADM | 0.707802 | 4 | 0 | 4 |
| CLK1 | SPAG16 | 0.705037 | 3 | 0 | 3 |
| CLK1 | C5orf51 | 0.701349 | 3 | 0 | 3 |
| CLK1 | SS18 | 0.701045 | 3 | 0 | 3 |
| CLK1 | TMEM161B | 0.700322 | 3 | 0 | 3 |
| CLK1 | ZNF879 | 0.698628 | 3 | 0 | 3 |
For details and further investigation, click here
