JAK2

 

Full name: Janus kinase 2 Alias Symbol: JTK10
Type: protein-coding gene Cytoband: 9p24.1
Entrez ID: 3717 HGNC ID: HGNC:6192 Ensembl Gene: ENSG00000096968 OMIM ID: 147796
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

JAK2 involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04630Jak-STAT signaling pathway
hsa04725Cholinergic synapse
hsa04917Prolactin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection

 

Expression of JAK2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 JAK2 3717 205842_s_at -0.9540 0.0900
GSE20347 JAK2 3717 205842_s_at -0.9650 0.0000
GSE23400 JAK2 3717 205842_s_at -0.3035 0.0000
GSE26886 JAK2 3717 205842_s_at -1.7210 0.0000
GSE29001 JAK2 3717 205841_at -0.9416 0.0024
GSE38129 JAK2 3717 205842_s_at -0.9140 0.0000
GSE45670 JAK2 3717 205842_s_at -0.4461 0.1393
GSE53622 JAK2 3717 40146 -0.9781 0.0000
GSE53624 JAK2 3717 40146 -0.9259 0.0000
GSE63941 JAK2 3717 205842_s_at -1.4041 0.0648
GSE77861 JAK2 3717 205842_s_at -0.7587 0.0081
GSE97050 JAK2 3717 A_33_P3878772 -0.3404 0.4158
SRP007169 JAK2 3717 RNAseq -1.3058 0.0001
SRP008496 JAK2 3717 RNAseq -1.3630 0.0000
SRP064894 JAK2 3717 RNAseq -0.5617 0.0447
SRP133303 JAK2 3717 RNAseq -0.7279 0.0002
SRP159526 JAK2 3717 RNAseq -1.5255 0.0003
SRP193095 JAK2 3717 RNAseq -1.2318 0.0000
SRP219564 JAK2 3717 RNAseq -0.5552 0.0720
TCGA JAK2 3717 RNAseq -0.2800 0.0018

Upregulated datasets: 0; Downregulated datasets: 5.  

 

Survival by JAK2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of JAK2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 JAK2 3717 1 17 12
GSE20123 JAK2 3717 1 16 13
GSE43470 JAK2 3717 5 11 27
GSE46452 JAK2 3717 2 23 34
GSE47630 JAK2 3717 5 26 9
GSE54993 JAK2 3717 6 3 61
GSE54994 JAK2 3717 9 17 27
GSE60625 JAK2 3717 0 2 9
GSE74703 JAK2 3717 5 8 23
GSE74704 JAK2 3717 0 12 8
TCGA JAK2 3717 14 50 32

Total number of gains: 48; Total number of losses: 185; Total Number of normals: 255.  

 

Somatic mutations of JAK2:

 

Generating mutation plots.

 

Highly correlated genes for JAK2:

 

Showing top 20/1591 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
JAK2PPM1K0.808153606
JAK2ZNF920.802706303
JAK2KDM5D0.792776303
JAK2ACTR20.791551303
JAK2CLK10.789137303
JAK2C3orf380.755805606
JAK2TRERF10.7515505
JAK2PRPF38B0.751403303
JAK2ECSCR0.745563303
JAK2BRK10.744342707
JAK2PRPH20.739992303
JAK2FBXO80.736063706
JAK2MTIF30.735876505
JAK2EPG50.731538706
JAK2CPEB30.73150310010
JAK2ZNF33A0.723629403
JAK2GOLGA40.715887808
JAK2AP1G10.71457403
JAK2LRRK20.714016806
JAK2SNORA680.711497404

For details and further investigation, click here