| Full name: Wnt ligand secretion mediator | Alias Symbol: FLJ23091|MRP|wls|EVI|mig-14 | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 79971 | HGNC ID: HGNC:30238 | Ensembl Gene: ENSG00000116729 | OMIM ID: 611514 |
| Drug and gene relationship at DGIdb | |||
Expression of WLS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WLS | 79971 | 228949_at | -0.4912 | 0.4781 | |
| GSE20347 | WLS | 79971 | 221958_s_at | -0.2419 | 0.1326 | |
| GSE23400 | WLS | 79971 | 221958_s_at | -0.3242 | 0.0433 | |
| GSE26886 | WLS | 79971 | 221958_s_at | -1.2391 | 0.0000 | |
| GSE29001 | WLS | 79971 | 221958_s_at | -0.1819 | 0.5869 | |
| GSE38129 | WLS | 79971 | 221958_s_at | -0.5898 | 0.0033 | |
| GSE45670 | WLS | 79971 | 221958_s_at | -0.5124 | 0.0022 | |
| GSE53622 | WLS | 79971 | 94039 | -0.7232 | 0.0000 | |
| GSE53624 | WLS | 79971 | 94039 | -0.2296 | 0.0106 | |
| GSE63941 | WLS | 79971 | 221958_s_at | -1.4277 | 0.1047 | |
| GSE77861 | WLS | 79971 | 221958_s_at | -0.3762 | 0.3895 | |
| GSE97050 | WLS | 79971 | A_33_P3280721 | -0.9432 | 0.1057 | |
| SRP007169 | WLS | 79971 | RNAseq | 0.2318 | 0.6178 | |
| SRP008496 | WLS | 79971 | RNAseq | 0.2945 | 0.2855 | |
| SRP064894 | WLS | 79971 | RNAseq | -0.0221 | 0.9024 | |
| SRP133303 | WLS | 79971 | RNAseq | -0.3062 | 0.3116 | |
| SRP159526 | WLS | 79971 | RNAseq | -0.7441 | 0.0604 | |
| SRP193095 | WLS | 79971 | RNAseq | -0.4180 | 0.0001 | |
| SRP219564 | WLS | 79971 | RNAseq | 0.0598 | 0.9493 | |
| TCGA | WLS | 79971 | RNAseq | -0.3804 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by WLS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WLS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WLS | 79971 | 2 | 6 | 22 | |
| GSE20123 | WLS | 79971 | 2 | 5 | 23 | |
| GSE43470 | WLS | 79971 | 4 | 4 | 35 | |
| GSE46452 | WLS | 79971 | 0 | 1 | 58 | |
| GSE47630 | WLS | 79971 | 7 | 6 | 27 | |
| GSE54993 | WLS | 79971 | 0 | 0 | 70 | |
| GSE54994 | WLS | 79971 | 6 | 4 | 43 | |
| GSE60625 | WLS | 79971 | 0 | 0 | 11 | |
| GSE74703 | WLS | 79971 | 3 | 3 | 30 | |
| GSE74704 | WLS | 79971 | 1 | 2 | 17 | |
| TCGA | WLS | 79971 | 8 | 22 | 66 |
Total number of gains: 33; Total number of losses: 53; Total Number of normals: 402.
Somatic mutations of WLS:
Generating mutation plots.
Highly correlated genes for WLS:
Showing top 20/552 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WLS | PDCD4 | 0.754099 | 3 | 0 | 3 |
| WLS | BRK1 | 0.745563 | 3 | 0 | 3 |
| WLS | CLK1 | 0.745163 | 3 | 0 | 3 |
| WLS | VPS39 | 0.733691 | 3 | 0 | 3 |
| WLS | BCS1L | 0.727572 | 3 | 0 | 3 |
| WLS | GGA3 | 0.722421 | 3 | 0 | 3 |
| WLS | LSM11 | 0.718943 | 4 | 0 | 4 |
| WLS | TNFSF12 | 0.716633 | 3 | 0 | 3 |
| WLS | JMY | 0.706042 | 4 | 0 | 3 |
| WLS | CD59 | 0.706032 | 3 | 0 | 3 |
| WLS | AMOTL1 | 0.705019 | 5 | 0 | 4 |
| WLS | RASSF3 | 0.703085 | 4 | 0 | 4 |
| WLS | ZFAND5 | 0.699458 | 4 | 0 | 4 |
| WLS | PPM1B | 0.697335 | 3 | 0 | 3 |
| WLS | RHBDF1 | 0.694309 | 3 | 0 | 3 |
| WLS | SLC35F1 | 0.690923 | 3 | 0 | 3 |
| WLS | C1QTNF7 | 0.688766 | 5 | 0 | 5 |
| WLS | TSR2 | 0.688182 | 3 | 0 | 3 |
| WLS | KCTD10 | 0.682555 | 4 | 0 | 3 |
| WLS | SORCS1 | 0.680046 | 4 | 0 | 3 |
For details and further investigation, click here
