| Full name: progestin and adipoQ receptor family member 8 | Alias Symbol: LMPB1|MPRB | ||
| Type: protein-coding gene | Cytoband: 6p12.2 | ||
| Entrez ID: 85315 | HGNC ID: HGNC:15708 | Ensembl Gene: ENSG00000170915 | OMIM ID: 607780 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PAQR8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAQR8 | 85315 | 226423_at | -1.7628 | 0.0423 | |
| GSE26886 | PAQR8 | 85315 | 226423_at | -2.5009 | 0.0000 | |
| GSE45670 | PAQR8 | 85315 | 226423_at | -1.9975 | 0.0000 | |
| GSE53622 | PAQR8 | 85315 | 77455 | -2.2891 | 0.0000 | |
| GSE53624 | PAQR8 | 85315 | 77455 | -2.3138 | 0.0000 | |
| GSE63941 | PAQR8 | 85315 | 226423_at | -0.0143 | 0.9803 | |
| GSE77861 | PAQR8 | 85315 | 226423_at | -1.4781 | 0.0016 | |
| GSE97050 | PAQR8 | 85315 | A_24_P334640 | -0.7637 | 0.1323 | |
| SRP007169 | PAQR8 | 85315 | RNAseq | -4.4401 | 0.0000 | |
| SRP008496 | PAQR8 | 85315 | RNAseq | -4.0076 | 0.0000 | |
| SRP064894 | PAQR8 | 85315 | RNAseq | -2.5299 | 0.0000 | |
| SRP133303 | PAQR8 | 85315 | RNAseq | -2.2075 | 0.0000 | |
| SRP159526 | PAQR8 | 85315 | RNAseq | -2.3299 | 0.0000 | |
| SRP193095 | PAQR8 | 85315 | RNAseq | -2.1513 | 0.0000 | |
| SRP219564 | PAQR8 | 85315 | RNAseq | -1.4899 | 0.0016 | |
| TCGA | PAQR8 | 85315 | RNAseq | -1.0470 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by PAQR8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAQR8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAQR8 | 85315 | 7 | 2 | 21 | |
| GSE20123 | PAQR8 | 85315 | 7 | 2 | 21 | |
| GSE43470 | PAQR8 | 85315 | 5 | 0 | 38 | |
| GSE46452 | PAQR8 | 85315 | 3 | 10 | 46 | |
| GSE47630 | PAQR8 | 85315 | 7 | 5 | 28 | |
| GSE54993 | PAQR8 | 85315 | 3 | 1 | 66 | |
| GSE54994 | PAQR8 | 85315 | 8 | 4 | 41 | |
| GSE60625 | PAQR8 | 85315 | 0 | 3 | 8 | |
| GSE74703 | PAQR8 | 85315 | 5 | 0 | 31 | |
| GSE74704 | PAQR8 | 85315 | 3 | 1 | 16 | |
| TCGA | PAQR8 | 85315 | 22 | 13 | 61 |
Total number of gains: 70; Total number of losses: 41; Total Number of normals: 377.
Somatic mutations of PAQR8:
Generating mutation plots.
Highly correlated genes for PAQR8:
Showing top 20/1842 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAQR8 | GYS2 | 0.868578 | 6 | 0 | 6 |
| PAQR8 | PMM1 | 0.857493 | 6 | 0 | 6 |
| PAQR8 | FNDC4 | 0.853304 | 6 | 0 | 6 |
| PAQR8 | CTTNBP2 | 0.845999 | 6 | 0 | 6 |
| PAQR8 | PAIP2B | 0.835696 | 7 | 0 | 7 |
| PAQR8 | SH3BGRL2 | 0.83526 | 8 | 0 | 8 |
| PAQR8 | HCG22 | 0.830611 | 6 | 0 | 6 |
| PAQR8 | TFAP2B | 0.830566 | 6 | 0 | 6 |
| PAQR8 | CGNL1 | 0.824921 | 7 | 0 | 7 |
| PAQR8 | FAM214A | 0.821629 | 6 | 0 | 6 |
| PAQR8 | DDAH1 | 0.82146 | 7 | 0 | 7 |
| PAQR8 | WNK4 | 0.820621 | 5 | 0 | 5 |
| PAQR8 | UPK1A | 0.819793 | 6 | 0 | 6 |
| PAQR8 | CAB39L | 0.818921 | 7 | 0 | 7 |
| PAQR8 | KAT2B | 0.81827 | 7 | 0 | 7 |
| PAQR8 | SASH1 | 0.817774 | 7 | 0 | 7 |
| PAQR8 | MGLL | 0.817509 | 7 | 0 | 7 |
| PAQR8 | SIM2 | 0.815216 | 7 | 0 | 7 |
| PAQR8 | PADI1 | 0.815116 | 4 | 0 | 4 |
| PAQR8 | EHD3 | 0.812374 | 7 | 0 | 7 |
For details and further investigation, click here
