| Full name: CDC like kinase 2 | Alias Symbol: clk2 | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 1196 | HGNC ID: HGNC:2069 | Ensembl Gene: ENSG00000176444 | OMIM ID: 602989 |
| Drug and gene relationship at DGIdb | |||
Expression of CLK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLK2 | 1196 | 203229_s_at | 0.4693 | 0.3972 | |
| GSE20347 | CLK2 | 1196 | 203229_s_at | 0.2954 | 0.0088 | |
| GSE23400 | CLK2 | 1196 | 203229_s_at | 0.3898 | 0.0000 | |
| GSE26886 | CLK2 | 1196 | 203229_s_at | -0.0014 | 0.9948 | |
| GSE29001 | CLK2 | 1196 | 203229_s_at | 0.2511 | 0.3597 | |
| GSE38129 | CLK2 | 1196 | 203229_s_at | 0.3640 | 0.0005 | |
| GSE45670 | CLK2 | 1196 | 203229_s_at | 0.2102 | 0.0550 | |
| GSE53622 | CLK2 | 1196 | 86953 | 0.3241 | 0.0000 | |
| GSE53624 | CLK2 | 1196 | 86953 | 0.2959 | 0.0000 | |
| GSE63941 | CLK2 | 1196 | 203229_s_at | 0.8323 | 0.0142 | |
| GSE77861 | CLK2 | 1196 | 203229_s_at | 0.6539 | 0.0305 | |
| GSE97050 | CLK2 | 1196 | A_24_P67027 | 0.0813 | 0.7378 | |
| SRP007169 | CLK2 | 1196 | RNAseq | -0.1342 | 0.7422 | |
| SRP008496 | CLK2 | 1196 | RNAseq | 0.3059 | 0.3447 | |
| SRP064894 | CLK2 | 1196 | RNAseq | 0.3344 | 0.0803 | |
| SRP133303 | CLK2 | 1196 | RNAseq | 0.0944 | 0.4546 | |
| SRP159526 | CLK2 | 1196 | RNAseq | 0.7571 | 0.0761 | |
| SRP193095 | CLK2 | 1196 | RNAseq | 0.3300 | 0.0075 | |
| SRP219564 | CLK2 | 1196 | RNAseq | 0.3355 | 0.3621 | |
| TCGA | CLK2 | 1196 | RNAseq | 0.1244 | 0.0216 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CLK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLK2 | 1196 | 14 | 0 | 16 | |
| GSE20123 | CLK2 | 1196 | 13 | 0 | 17 | |
| GSE43470 | CLK2 | 1196 | 7 | 3 | 33 | |
| GSE46452 | CLK2 | 1196 | 2 | 1 | 56 | |
| GSE47630 | CLK2 | 1196 | 14 | 0 | 26 | |
| GSE54993 | CLK2 | 1196 | 0 | 4 | 66 | |
| GSE54994 | CLK2 | 1196 | 16 | 0 | 37 | |
| GSE60625 | CLK2 | 1196 | 0 | 0 | 11 | |
| GSE74703 | CLK2 | 1196 | 7 | 2 | 27 | |
| GSE74704 | CLK2 | 1196 | 6 | 0 | 14 | |
| TCGA | CLK2 | 1196 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.
Somatic mutations of CLK2:
Generating mutation plots.
Highly correlated genes for CLK2:
Showing top 20/965 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLK2 | PPP1R16A | 0.834971 | 3 | 0 | 3 |
| CLK2 | PACSIN3 | 0.789326 | 3 | 0 | 3 |
| CLK2 | DDX59 | 0.787951 | 3 | 0 | 3 |
| CLK2 | NUFIP2 | 0.779074 | 3 | 0 | 3 |
| CLK2 | PSAP | 0.777142 | 3 | 0 | 3 |
| CLK2 | SLC26A11 | 0.773392 | 3 | 0 | 3 |
| CLK2 | ZNF787 | 0.766115 | 3 | 0 | 3 |
| CLK2 | MRPL38 | 0.761664 | 3 | 0 | 3 |
| CLK2 | ZNF567 | 0.744072 | 3 | 0 | 3 |
| CLK2 | CDK2AP2 | 0.736886 | 3 | 0 | 3 |
| CLK2 | RLIM | 0.736263 | 4 | 0 | 4 |
| CLK2 | PITRM1 | 0.729638 | 3 | 0 | 3 |
| CLK2 | NACC1 | 0.725251 | 3 | 0 | 3 |
| CLK2 | PDCD2L | 0.724217 | 4 | 0 | 3 |
| CLK2 | TPD52 | 0.72415 | 3 | 0 | 3 |
| CLK2 | PTGES2 | 0.723574 | 3 | 0 | 3 |
| CLK2 | HCFC1R1 | 0.722644 | 3 | 0 | 3 |
| CLK2 | ZBTB11 | 0.722568 | 3 | 0 | 3 |
| CLK2 | FAM184B | 0.721751 | 3 | 0 | 3 |
| CLK2 | SNAPC2 | 0.719448 | 3 | 0 | 3 |
For details and further investigation, click here
