| Full name: protein S | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q11.1 | ||
| Entrez ID: 5627 | HGNC ID: HGNC:9456 | Ensembl Gene: ENSG00000184500 | OMIM ID: 176880 |
| Drug and gene relationship at DGIdb | |||
PROS1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of PROS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PROS1 | 5627 | 207808_s_at | -0.8343 | 0.0943 | |
| GSE20347 | PROS1 | 5627 | 207808_s_at | -0.9994 | 0.0064 | |
| GSE23400 | PROS1 | 5627 | 207808_s_at | -0.3251 | 0.0640 | |
| GSE26886 | PROS1 | 5627 | 207808_s_at | -0.9870 | 0.0173 | |
| GSE29001 | PROS1 | 5627 | 207808_s_at | -0.9806 | 0.0313 | |
| GSE38129 | PROS1 | 5627 | 207808_s_at | -1.1737 | 0.0002 | |
| GSE45670 | PROS1 | 5627 | 207808_s_at | -0.7604 | 0.0291 | |
| GSE53622 | PROS1 | 5627 | 61321 | -1.2753 | 0.0000 | |
| GSE53624 | PROS1 | 5627 | 61321 | -1.2168 | 0.0000 | |
| GSE63941 | PROS1 | 5627 | 207808_s_at | -3.2978 | 0.0075 | |
| GSE77861 | PROS1 | 5627 | 207808_s_at | -0.3597 | 0.4724 | |
| GSE97050 | PROS1 | 5627 | A_23_P73114 | -0.4866 | 0.1403 | |
| SRP007169 | PROS1 | 5627 | RNAseq | -1.1887 | 0.0405 | |
| SRP008496 | PROS1 | 5627 | RNAseq | -0.4812 | 0.2263 | |
| SRP064894 | PROS1 | 5627 | RNAseq | 0.0023 | 0.9924 | |
| SRP133303 | PROS1 | 5627 | RNAseq | -0.9665 | 0.0014 | |
| SRP159526 | PROS1 | 5627 | RNAseq | -0.8508 | 0.1474 | |
| SRP193095 | PROS1 | 5627 | RNAseq | -0.8192 | 0.0006 | |
| SRP219564 | PROS1 | 5627 | RNAseq | -0.0945 | 0.9088 | |
| TCGA | PROS1 | 5627 | RNAseq | -0.2924 | 0.0399 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PROS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PROS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PROS1 | 5627 | 17 | 4 | 9 | |
| GSE20123 | PROS1 | 5627 | 16 | 4 | 10 | |
| GSE43470 | PROS1 | 5627 | 8 | 9 | 26 | |
| GSE46452 | PROS1 | 5627 | 5 | 15 | 39 | |
| GSE47630 | PROS1 | 5627 | 14 | 8 | 18 | |
| GSE54993 | PROS1 | 5627 | 4 | 3 | 63 | |
| GSE54994 | PROS1 | 5627 | 13 | 16 | 24 | |
| GSE60625 | PROS1 | 5627 | 0 | 6 | 5 | |
| GSE74703 | PROS1 | 5627 | 7 | 7 | 22 | |
| GSE74704 | PROS1 | 5627 | 11 | 3 | 6 | |
| TCGA | PROS1 | 5627 | 33 | 38 | 25 |
Total number of gains: 128; Total number of losses: 113; Total Number of normals: 247.
Somatic mutations of PROS1:
Generating mutation plots.
Highly correlated genes for PROS1:
Showing top 20/955 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PROS1 | CLEC3B | 0.775379 | 3 | 0 | 3 |
| PROS1 | PI16 | 0.77217 | 3 | 0 | 3 |
| PROS1 | CYP21A2 | 0.741407 | 3 | 0 | 3 |
| PROS1 | VAPA | 0.741383 | 3 | 0 | 3 |
| PROS1 | CYP4V2 | 0.736443 | 3 | 0 | 3 |
| PROS1 | TINF2 | 0.72535 | 3 | 0 | 3 |
| PROS1 | HMGN3 | 0.714508 | 3 | 0 | 3 |
| PROS1 | CLK3 | 0.708349 | 3 | 0 | 3 |
| PROS1 | CLDND1 | 0.705159 | 4 | 0 | 3 |
| PROS1 | CCL14 | 0.702617 | 3 | 0 | 3 |
| PROS1 | NR2F1 | 0.699826 | 3 | 0 | 3 |
| PROS1 | PCBD2 | 0.69964 | 4 | 0 | 4 |
| PROS1 | CYYR1 | 0.697945 | 6 | 0 | 6 |
| PROS1 | ZNF334 | 0.696388 | 3 | 0 | 3 |
| PROS1 | ATP1B2 | 0.691258 | 4 | 0 | 4 |
| PROS1 | LRRK2 | 0.683429 | 5 | 0 | 4 |
| PROS1 | FYTTD1 | 0.683389 | 3 | 0 | 3 |
| PROS1 | SORCS1 | 0.680814 | 4 | 0 | 3 |
| PROS1 | HOXA3 | 0.679685 | 4 | 0 | 4 |
| PROS1 | TXNDC11 | 0.676437 | 3 | 0 | 3 |
For details and further investigation, click here
