| Full name: sprouty RTK signaling antagonist 1 | Alias Symbol: hSPRY1 | ||
| Type: protein-coding gene | Cytoband: 4q28.1 | ||
| Entrez ID: 10252 | HGNC ID: HGNC:11269 | Ensembl Gene: ENSG00000164056 | OMIM ID: 602465 |
| Drug and gene relationship at DGIdb | |||
Expression of SPRY1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPRY1 | 10252 | 212558_at | -1.1917 | 0.0929 | |
| GSE20347 | SPRY1 | 10252 | 212558_at | -1.0946 | 0.0000 | |
| GSE23400 | SPRY1 | 10252 | 212558_at | -0.3368 | 0.0009 | |
| GSE26886 | SPRY1 | 10252 | 212558_at | -0.7313 | 0.0017 | |
| GSE29001 | SPRY1 | 10252 | 212558_at | -0.9957 | 0.0012 | |
| GSE38129 | SPRY1 | 10252 | 212558_at | -1.1855 | 0.0000 | |
| GSE45670 | SPRY1 | 10252 | 212558_at | -2.0841 | 0.0000 | |
| GSE53622 | SPRY1 | 10252 | 120301 | -0.7611 | 0.0000 | |
| GSE53624 | SPRY1 | 10252 | 120301 | -0.5682 | 0.0000 | |
| GSE63941 | SPRY1 | 10252 | 212558_at | -2.5455 | 0.0011 | |
| GSE77861 | SPRY1 | 10252 | 212558_at | -0.2356 | 0.4446 | |
| GSE97050 | SPRY1 | 10252 | A_33_P3268910 | 0.0705 | 0.7973 | |
| SRP007169 | SPRY1 | 10252 | RNAseq | -0.8959 | 0.0258 | |
| SRP008496 | SPRY1 | 10252 | RNAseq | -1.0025 | 0.0003 | |
| SRP064894 | SPRY1 | 10252 | RNAseq | -0.6900 | 0.0302 | |
| SRP133303 | SPRY1 | 10252 | RNAseq | -0.7451 | 0.0122 | |
| SRP159526 | SPRY1 | 10252 | RNAseq | -0.4879 | 0.2473 | |
| SRP193095 | SPRY1 | 10252 | RNAseq | -0.3890 | 0.0182 | |
| SRP219564 | SPRY1 | 10252 | RNAseq | -0.0974 | 0.8721 | |
| TCGA | SPRY1 | 10252 | RNAseq | -0.4614 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by SPRY1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPRY1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPRY1 | 10252 | 0 | 13 | 17 | |
| GSE20123 | SPRY1 | 10252 | 0 | 13 | 17 | |
| GSE43470 | SPRY1 | 10252 | 0 | 13 | 30 | |
| GSE46452 | SPRY1 | 10252 | 1 | 36 | 22 | |
| GSE47630 | SPRY1 | 10252 | 0 | 22 | 18 | |
| GSE54993 | SPRY1 | 10252 | 9 | 0 | 61 | |
| GSE54994 | SPRY1 | 10252 | 1 | 10 | 42 | |
| GSE60625 | SPRY1 | 10252 | 0 | 1 | 10 | |
| GSE74703 | SPRY1 | 10252 | 0 | 11 | 25 | |
| GSE74704 | SPRY1 | 10252 | 0 | 7 | 13 | |
| TCGA | SPRY1 | 10252 | 8 | 35 | 53 |
Total number of gains: 19; Total number of losses: 161; Total Number of normals: 308.
Somatic mutations of SPRY1:
Generating mutation plots.
Highly correlated genes for SPRY1:
Showing top 20/1357 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPRY1 | GPIHBP1 | 0.839028 | 3 | 0 | 3 |
| SPRY1 | CCIN | 0.802271 | 3 | 0 | 3 |
| SPRY1 | NMT2 | 0.784299 | 3 | 0 | 3 |
| SPRY1 | COL14A1 | 0.742503 | 10 | 0 | 9 |
| SPRY1 | ABCA8 | 0.73869 | 11 | 0 | 10 |
| SPRY1 | FGF7 | 0.737801 | 7 | 0 | 7 |
| SPRY1 | ACRBP | 0.736666 | 3 | 0 | 3 |
| SPRY1 | SLC16A4 | 0.735611 | 7 | 0 | 7 |
| SPRY1 | MYCN | 0.734614 | 3 | 0 | 3 |
| SPRY1 | TRIM26 | 0.729678 | 3 | 0 | 3 |
| SPRY1 | AFF3 | 0.725924 | 3 | 0 | 3 |
| SPRY1 | PREX2 | 0.719706 | 4 | 0 | 3 |
| SPRY1 | ITIH5 | 0.717411 | 9 | 0 | 9 |
| SPRY1 | DNAJB14 | 0.716291 | 3 | 0 | 3 |
| SPRY1 | CLSTN2 | 0.715547 | 3 | 0 | 3 |
| SPRY1 | CLEC3B | 0.713698 | 3 | 0 | 3 |
| SPRY1 | LIFR | 0.712145 | 5 | 0 | 5 |
| SPRY1 | PTGER3 | 0.711908 | 4 | 0 | 4 |
| SPRY1 | MAOB | 0.70879 | 9 | 0 | 9 |
| SPRY1 | C2orf88 | 0.704715 | 3 | 0 | 3 |
For details and further investigation, click here
