| Full name: ubiquitin protein ligase E3A | Alias Symbol: AS|ANCR|E6-AP|FLJ26981 | ||
| Type: protein-coding gene | Cytoband: 15q11.2 | ||
| Entrez ID: 7337 | HGNC ID: HGNC:12496 | Ensembl Gene: ENSG00000114062 | OMIM ID: 601623 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBE3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE3A | 7337 | 211285_s_at | -0.2161 | 0.5691 | |
| GSE20347 | UBE3A | 7337 | 211285_s_at | 0.0342 | 0.8155 | |
| GSE23400 | UBE3A | 7337 | 213291_s_at | 0.0006 | 0.9909 | |
| GSE26886 | UBE3A | 7337 | 211285_s_at | 0.2042 | 0.2074 | |
| GSE29001 | UBE3A | 7337 | 211285_s_at | -0.1490 | 0.5954 | |
| GSE38129 | UBE3A | 7337 | 211285_s_at | -0.0799 | 0.6218 | |
| GSE45670 | UBE3A | 7337 | 211285_s_at | -0.2246 | 0.0207 | |
| GSE53622 | UBE3A | 7337 | 80237 | -0.6667 | 0.0000 | |
| GSE53624 | UBE3A | 7337 | 34180 | -0.2678 | 0.0343 | |
| GSE63941 | UBE3A | 7337 | 211285_s_at | -0.3440 | 0.4909 | |
| GSE77861 | UBE3A | 7337 | 211285_s_at | 0.0612 | 0.8591 | |
| GSE97050 | UBE3A | 7337 | A_33_P3400429 | -0.6660 | 0.1005 | |
| SRP007169 | UBE3A | 7337 | RNAseq | -0.3103 | 0.3685 | |
| SRP008496 | UBE3A | 7337 | RNAseq | -0.2279 | 0.2338 | |
| SRP064894 | UBE3A | 7337 | RNAseq | -0.2349 | 0.1711 | |
| SRP133303 | UBE3A | 7337 | RNAseq | -0.1204 | 0.3994 | |
| SRP159526 | UBE3A | 7337 | RNAseq | -0.1684 | 0.5813 | |
| SRP193095 | UBE3A | 7337 | RNAseq | -0.2390 | 0.0079 | |
| SRP219564 | UBE3A | 7337 | RNAseq | -0.5541 | 0.0207 | |
| TCGA | UBE3A | 7337 | RNAseq | -0.0066 | 0.8759 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBE3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBE3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE3A | 7337 | 2 | 7 | 21 | |
| GSE20123 | UBE3A | 7337 | 2 | 7 | 21 | |
| GSE43470 | UBE3A | 7337 | 3 | 5 | 35 | |
| GSE46452 | UBE3A | 7337 | 3 | 7 | 49 | |
| GSE47630 | UBE3A | 7337 | 8 | 11 | 21 | |
| GSE54993 | UBE3A | 7337 | 4 | 6 | 60 | |
| GSE54994 | UBE3A | 7337 | 7 | 6 | 40 | |
| GSE60625 | UBE3A | 7337 | 4 | 3 | 4 | |
| GSE74703 | UBE3A | 7337 | 3 | 3 | 30 | |
| GSE74704 | UBE3A | 7337 | 1 | 5 | 14 | |
| TCGA | UBE3A | 7337 | 17 | 20 | 59 |
Total number of gains: 54; Total number of losses: 80; Total Number of normals: 354.
Somatic mutations of UBE3A:
Generating mutation plots.
Highly correlated genes for UBE3A:
Showing top 20/425 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE3A | TMEM218 | 0.760124 | 3 | 0 | 3 |
| UBE3A | TXNRD1 | 0.754165 | 3 | 0 | 3 |
| UBE3A | ROGDI | 0.750907 | 3 | 0 | 3 |
| UBE3A | ARL1 | 0.748354 | 3 | 0 | 3 |
| UBE3A | FAM76B | 0.741719 | 3 | 0 | 3 |
| UBE3A | FZD7 | 0.740316 | 3 | 0 | 3 |
| UBE3A | CFL2 | 0.740097 | 3 | 0 | 3 |
| UBE3A | KIAA1328 | 0.731213 | 3 | 0 | 3 |
| UBE3A | ZRANB1 | 0.729176 | 3 | 0 | 3 |
| UBE3A | RHOU | 0.725703 | 3 | 0 | 3 |
| UBE3A | INO80 | 0.723678 | 4 | 0 | 4 |
| UBE3A | XPO4 | 0.7235 | 4 | 0 | 3 |
| UBE3A | NACC2 | 0.721203 | 3 | 0 | 3 |
| UBE3A | PDCD7 | 0.71723 | 5 | 0 | 4 |
| UBE3A | CCDC146 | 0.716479 | 3 | 0 | 3 |
| UBE3A | MED7 | 0.71248 | 3 | 0 | 3 |
| UBE3A | EPC2 | 0.71128 | 3 | 0 | 3 |
| UBE3A | STAG1 | 0.703072 | 3 | 0 | 3 |
| UBE3A | MKLN1 | 0.702175 | 4 | 0 | 3 |
| UBE3A | STAM2 | 0.702062 | 3 | 0 | 3 |
For details and further investigation, click here
