ARPC1A

 

Full name: actin related protein 2/3 complex subunit 1A Alias Symbol: SOP2Hs|SOP2L|Arc40
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 10552 HGNC ID: HGNC:703 Ensembl Gene: ENSG00000241685 OMIM ID: 604220
Drug and gene relationship at DGIdb
Screen Evidence:

 

ARPC1A involved pathways:

KEGG pathway Description View
hsa04666Fc gamma R-mediated phagocytosis
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05130Pathogenic Escherichia coli infection
hsa05131Shigellosis
hsa05132Salmonella infection

 

Expression of ARPC1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ARPC1A 10552 200950_at 0.2867 0.6120
GSE20347 ARPC1A 10552 200950_at 0.0722 0.7748
GSE23400 ARPC1A 10552 200950_at 0.1198 0.2001
GSE26886 ARPC1A 10552 200950_at -1.4862 0.0000
GSE29001 ARPC1A 10552 200950_at -0.3383 0.3927
GSE38129 ARPC1A 10552 200950_at 0.3569 0.0243
GSE45670 ARPC1A 10552 200950_at 0.3978 0.0396
GSE53622 ARPC1A 10552 8057 0.2716 0.0029
GSE53624 ARPC1A 10552 8057 0.1308 0.0255
GSE63941 ARPC1A 10552 200950_at 0.2786 0.5326
GSE77861 ARPC1A 10552 200950_at 0.1784 0.4438
GSE97050 ARPC1A 10552 A_24_P72479 0.4214 0.2851
SRP007169 ARPC1A 10552 RNAseq -0.5852 0.1188
SRP008496 ARPC1A 10552 RNAseq -0.0890 0.8047
SRP064894 ARPC1A 10552 RNAseq 0.0525 0.7990
SRP133303 ARPC1A 10552 RNAseq 0.4637 0.0103
SRP159526 ARPC1A 10552 RNAseq 0.0496 0.9030
SRP193095 ARPC1A 10552 RNAseq 0.0995 0.5101
SRP219564 ARPC1A 10552 RNAseq 0.0577 0.8112
TCGA ARPC1A 10552 RNAseq 0.0887 0.1219

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by ARPC1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ARPC1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ARPC1A 10552 13 0 17
GSE20123 ARPC1A 10552 13 0 17
GSE43470 ARPC1A 10552 6 1 36
GSE46452 ARPC1A 10552 11 1 47
GSE47630 ARPC1A 10552 8 3 29
GSE54993 ARPC1A 10552 1 9 60
GSE54994 ARPC1A 10552 16 3 34
GSE60625 ARPC1A 10552 0 0 11
GSE74703 ARPC1A 10552 6 1 29
GSE74704 ARPC1A 10552 9 0 11
TCGA ARPC1A 10552 54 4 38

Total number of gains: 137; Total number of losses: 22; Total Number of normals: 329.  

 

Somatic mutations of ARPC1A:

 

Generating mutation plots.

 

Highly correlated genes for ARPC1A:

 

Showing top 20/641 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ARPC1ACIB10.834211303
ARPC1ACNOT10.823992404
ARPC1AUSP380.815422303
ARPC1APRKCH0.801155404
ARPC1ARABGGTA0.797224303
ARPC1APRMT60.786681303
ARPC1AATP11B0.77639303
ARPC1ANCK20.768801303
ARPC1AASH2L0.76624303
ARPC1ANAA200.764712303
ARPC1AACTR20.758353303
ARPC1ACD590.752611303
ARPC1AMCU0.751635303
ARPC1AVPS250.751456303
ARPC1AEXOC10.750957303
ARPC1AUSO10.749877303
ARPC1ABTF30.749388303
ARPC1ANFKB10.743991404
ARPC1APOLB0.743528404
ARPC1ATRIP120.742594403

For details and further investigation, click here