| Full name: cytochrome c oxidase assembly factor 3 | Alias Symbol: HSPC009|MITRAC12|COX25 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 28958 | HGNC ID: HGNC:24990 | Ensembl Gene: ENSG00000183978 | OMIM ID: 614775 |
Screen Evidence:
| |||
Expression of COA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COA3 | 28958 | 218026_at | -0.4971 | 0.1310 | |
| GSE20347 | COA3 | 28958 | 218026_at | -0.7277 | 0.0000 | |
| GSE23400 | COA3 | 28958 | 218026_at | -0.4477 | 0.0000 | |
| GSE26886 | COA3 | 28958 | 218026_at | -0.2538 | 0.1144 | |
| GSE29001 | COA3 | 28958 | 218026_at | -0.7183 | 0.0414 | |
| GSE38129 | COA3 | 28958 | 218026_at | -0.4696 | 0.0022 | |
| GSE45670 | COA3 | 28958 | 218026_at | -0.1482 | 0.4924 | |
| GSE53622 | COA3 | 28958 | 131120 | -0.7330 | 0.0000 | |
| GSE53624 | COA3 | 28958 | 131120 | -0.7823 | 0.0000 | |
| GSE63941 | COA3 | 28958 | 218026_at | 0.2139 | 0.5360 | |
| GSE77861 | COA3 | 28958 | 218026_at | -0.4704 | 0.2052 | |
| SRP007169 | COA3 | 28958 | RNAseq | -1.1026 | 0.0133 | |
| SRP008496 | COA3 | 28958 | RNAseq | -1.2731 | 0.0000 | |
| SRP064894 | COA3 | 28958 | RNAseq | -0.3968 | 0.2304 | |
| SRP133303 | COA3 | 28958 | RNAseq | -0.6137 | 0.0005 | |
| SRP159526 | COA3 | 28958 | RNAseq | -0.6118 | 0.0002 | |
| SRP193095 | COA3 | 28958 | RNAseq | -1.1504 | 0.0000 | |
| SRP219564 | COA3 | 28958 | RNAseq | -0.5400 | 0.0598 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by COA3 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of COA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COA3 | 28958 | 6 | 2 | 22 | |
| GSE20123 | COA3 | 28958 | 6 | 2 | 22 | |
| GSE43470 | COA3 | 28958 | 1 | 2 | 40 | |
| GSE46452 | COA3 | 28958 | 34 | 0 | 25 | |
| GSE47630 | COA3 | 28958 | 8 | 1 | 31 | |
| GSE54993 | COA3 | 28958 | 3 | 4 | 63 | |
| GSE54994 | COA3 | 28958 | 8 | 5 | 40 | |
| GSE60625 | COA3 | 28958 | 4 | 0 | 7 | |
| GSE74703 | COA3 | 28958 | 1 | 1 | 34 | |
| GSE74704 | COA3 | 28958 | 4 | 1 | 15 | |
| TCGA | COA3 | 28958 | 22 | 7 | 67 |
Total number of gains: 97; Total number of losses: 25; Total Number of normals: 366.
Somatic mutations of COA3:
Generating mutation plots.
Highly correlated genes for COA3:
Showing top 20/1055 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COA3 | GBP6 | 0.795246 | 3 | 0 | 3 |
| COA3 | ALKBH7 | 0.772588 | 4 | 0 | 4 |
| COA3 | VPS25 | 0.725461 | 7 | 0 | 7 |
| COA3 | YPEL3 | 0.703156 | 5 | 0 | 5 |
| COA3 | SNORA68 | 0.698681 | 4 | 0 | 4 |
| COA3 | FAM3B | 0.694282 | 6 | 0 | 5 |
| COA3 | RUNDC3B | 0.693636 | 4 | 0 | 4 |
| COA3 | RPUSD3 | 0.691096 | 3 | 0 | 3 |
| COA3 | ZNRF1 | 0.687471 | 3 | 0 | 3 |
| COA3 | MPP7 | 0.686278 | 5 | 0 | 5 |
| COA3 | C5orf66-AS1 | 0.680843 | 6 | 0 | 5 |
| COA3 | CTTNBP2 | 0.678564 | 5 | 0 | 5 |
| COA3 | MYO5B | 0.678111 | 5 | 0 | 4 |
| COA3 | ST6GALNAC1 | 0.678015 | 6 | 0 | 5 |
| COA3 | MFSD5 | 0.67642 | 10 | 0 | 8 |
| COA3 | IKZF2 | 0.674696 | 6 | 0 | 4 |
| COA3 | ATP13A4 | 0.671008 | 6 | 0 | 5 |
| COA3 | VSIG2 | 0.669513 | 5 | 0 | 5 |
| COA3 | SMIM5 | 0.667681 | 6 | 0 | 5 |
| COA3 | SLC9A9 | 0.664829 | 6 | 0 | 5 |
For details and further investigation, click here
