| Full name: IKAROS family zinc finger 2 | Alias Symbol: Helios | ||
| Type: protein-coding gene | Cytoband: 2q34 | ||
| Entrez ID: 22807 | HGNC ID: HGNC:13177 | Ensembl Gene: ENSG00000030419 | OMIM ID: 606234 |
| Drug and gene relationship at DGIdb | |||
Expression of IKZF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IKZF2 | 22807 | 231929_at | -1.9310 | 0.1542 | |
| GSE20347 | IKZF2 | 22807 | 220567_at | -0.2954 | 0.0046 | |
| GSE23400 | IKZF2 | 22807 | 220567_at | -0.1417 | 0.0001 | |
| GSE26886 | IKZF2 | 22807 | 231929_at | -3.9338 | 0.0000 | |
| GSE29001 | IKZF2 | 22807 | 220567_at | -0.5073 | 0.0086 | |
| GSE38129 | IKZF2 | 22807 | 220567_at | -0.2922 | 0.0001 | |
| GSE45670 | IKZF2 | 22807 | 231929_at | -1.2558 | 0.0200 | |
| GSE53622 | IKZF2 | 22807 | 76163 | -2.4652 | 0.0000 | |
| GSE53624 | IKZF2 | 22807 | 76163 | -2.3024 | 0.0000 | |
| GSE63941 | IKZF2 | 22807 | 231929_at | 0.8513 | 0.4535 | |
| GSE77861 | IKZF2 | 22807 | 231929_at | -2.7044 | 0.0015 | |
| GSE97050 | IKZF2 | 22807 | A_33_P3328485 | -0.5405 | 0.3394 | |
| SRP007169 | IKZF2 | 22807 | RNAseq | -2.9954 | 0.0000 | |
| SRP008496 | IKZF2 | 22807 | RNAseq | -3.3522 | 0.0000 | |
| SRP064894 | IKZF2 | 22807 | RNAseq | -2.8709 | 0.0000 | |
| SRP133303 | IKZF2 | 22807 | RNAseq | -1.9818 | 0.0000 | |
| SRP159526 | IKZF2 | 22807 | RNAseq | -2.9708 | 0.0000 | |
| SRP193095 | IKZF2 | 22807 | RNAseq | -2.5866 | 0.0000 | |
| SRP219564 | IKZF2 | 22807 | RNAseq | -3.1501 | 0.0001 | |
| TCGA | IKZF2 | 22807 | RNAseq | -0.0458 | 0.7728 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by IKZF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IKZF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IKZF2 | 22807 | 1 | 13 | 16 | |
| GSE20123 | IKZF2 | 22807 | 1 | 13 | 16 | |
| GSE43470 | IKZF2 | 22807 | 1 | 6 | 36 | |
| GSE46452 | IKZF2 | 22807 | 0 | 5 | 54 | |
| GSE47630 | IKZF2 | 22807 | 4 | 5 | 31 | |
| GSE54993 | IKZF2 | 22807 | 0 | 3 | 67 | |
| GSE54994 | IKZF2 | 22807 | 8 | 9 | 36 | |
| GSE60625 | IKZF2 | 22807 | 0 | 3 | 8 | |
| GSE74703 | IKZF2 | 22807 | 1 | 5 | 30 | |
| GSE74704 | IKZF2 | 22807 | 1 | 7 | 12 | |
| TCGA | IKZF2 | 22807 | 13 | 28 | 55 |
Total number of gains: 30; Total number of losses: 97; Total Number of normals: 361.
Somatic mutations of IKZF2:
Generating mutation plots.
Highly correlated genes for IKZF2:
Showing top 20/1585 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IKZF2 | C5orf66-AS1 | 0.906169 | 6 | 0 | 6 |
| IKZF2 | UPK3B | 0.890958 | 3 | 0 | 3 |
| IKZF2 | FAM3B | 0.882779 | 6 | 0 | 6 |
| IKZF2 | CAPN14 | 0.862067 | 6 | 0 | 6 |
| IKZF2 | ATP13A4 | 0.857553 | 7 | 0 | 7 |
| IKZF2 | GBP6 | 0.852601 | 4 | 0 | 4 |
| IKZF2 | SMIM5 | 0.849309 | 6 | 0 | 6 |
| IKZF2 | ST6GALNAC1 | 0.845492 | 8 | 0 | 8 |
| IKZF2 | A2ML1 | 0.840684 | 7 | 0 | 7 |
| IKZF2 | ARHGAP27 | 0.832353 | 7 | 0 | 7 |
| IKZF2 | NCCRP1 | 0.831745 | 3 | 0 | 3 |
| IKZF2 | SH3BGRL2 | 0.831615 | 8 | 0 | 8 |
| IKZF2 | MPP7 | 0.830593 | 6 | 0 | 6 |
| IKZF2 | FAM3D | 0.828049 | 8 | 0 | 7 |
| IKZF2 | TP53INP2 | 0.82303 | 6 | 0 | 6 |
| IKZF2 | KLB | 0.813904 | 6 | 0 | 6 |
| IKZF2 | EPGN | 0.811939 | 3 | 0 | 3 |
| IKZF2 | MACC1 | 0.810835 | 8 | 0 | 8 |
| IKZF2 | SPINK7 | 0.808865 | 7 | 0 | 7 |
| IKZF2 | MUC20 | 0.803755 | 8 | 0 | 8 |
For details and further investigation, click here
