| Full name: collagen type IV alpha 4 chain | Alias Symbol: CA44 | ||
| Type: protein-coding gene | Cytoband: 2q36.3 | ||
| Entrez ID: 1286 | HGNC ID: HGNC:2206 | Ensembl Gene: ENSG00000081052 | OMIM ID: 120131 |
| Drug and gene relationship at DGIdb | |||
COL4A4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of COL4A4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL4A4 | 1286 | 229779_at | -0.5200 | 0.5655 | |
| GSE20347 | COL4A4 | 1286 | 214602_at | -0.1248 | 0.1341 | |
| GSE23400 | COL4A4 | 1286 | 214602_at | -0.0439 | 0.2521 | |
| GSE26886 | COL4A4 | 1286 | 241565_at | -0.0340 | 0.7630 | |
| GSE29001 | COL4A4 | 1286 | 214602_at | 0.2145 | 0.7062 | |
| GSE38129 | COL4A4 | 1286 | 214602_at | -0.3282 | 0.0340 | |
| GSE45670 | COL4A4 | 1286 | 241565_at | -0.0034 | 0.9718 | |
| GSE53622 | COL4A4 | 1286 | 39161 | -1.1957 | 0.0000 | |
| GSE53624 | COL4A4 | 1286 | 39161 | -0.9272 | 0.0000 | |
| GSE63941 | COL4A4 | 1286 | 229779_at | -0.0218 | 0.9846 | |
| GSE77861 | COL4A4 | 1286 | 241565_at | -0.2216 | 0.0604 | |
| GSE97050 | COL4A4 | 1286 | A_33_P3227400 | 0.1426 | 0.7567 | |
| SRP064894 | COL4A4 | 1286 | RNAseq | -0.2086 | 0.6502 | |
| SRP133303 | COL4A4 | 1286 | RNAseq | -0.6122 | 0.2173 | |
| SRP159526 | COL4A4 | 1286 | RNAseq | -0.4304 | 0.3505 | |
| SRP193095 | COL4A4 | 1286 | RNAseq | 0.1295 | 0.7039 | |
| SRP219564 | COL4A4 | 1286 | RNAseq | 1.3679 | 0.1389 | |
| TCGA | COL4A4 | 1286 | RNAseq | -1.1191 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by COL4A4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL4A4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL4A4 | 1286 | 2 | 12 | 16 | |
| GSE20123 | COL4A4 | 1286 | 2 | 12 | 16 | |
| GSE43470 | COL4A4 | 1286 | 0 | 7 | 36 | |
| GSE46452 | COL4A4 | 1286 | 0 | 5 | 54 | |
| GSE47630 | COL4A4 | 1286 | 4 | 5 | 31 | |
| GSE54993 | COL4A4 | 1286 | 1 | 2 | 67 | |
| GSE54994 | COL4A4 | 1286 | 6 | 11 | 36 | |
| GSE60625 | COL4A4 | 1286 | 0 | 3 | 8 | |
| GSE74703 | COL4A4 | 1286 | 0 | 6 | 30 | |
| GSE74704 | COL4A4 | 1286 | 2 | 6 | 12 | |
| TCGA | COL4A4 | 1286 | 13 | 26 | 57 |
Total number of gains: 30; Total number of losses: 95; Total Number of normals: 363.
Somatic mutations of COL4A4:
Generating mutation plots.
Highly correlated genes for COL4A4:
Showing top 20/372 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL4A4 | C11orf53 | 0.747 | 3 | 0 | 3 |
| COL4A4 | GIMAP5 | 0.712955 | 3 | 0 | 3 |
| COL4A4 | GIMAP7 | 0.709025 | 4 | 0 | 4 |
| COL4A4 | CEP112 | 0.690187 | 3 | 0 | 3 |
| COL4A4 | GIMAP1 | 0.686061 | 4 | 0 | 4 |
| COL4A4 | LGALS2 | 0.674745 | 4 | 0 | 3 |
| COL4A4 | COL23A1 | 0.674338 | 3 | 0 | 3 |
| COL4A4 | NLGN4X | 0.673897 | 3 | 0 | 3 |
| COL4A4 | CLDN11 | 0.6712 | 5 | 0 | 5 |
| COL4A4 | FAM166A | 0.667633 | 3 | 0 | 3 |
| COL4A4 | CLU | 0.666346 | 5 | 0 | 4 |
| COL4A4 | CHRDL2 | 0.651235 | 5 | 0 | 4 |
| COL4A4 | FGF6 | 0.650982 | 3 | 0 | 3 |
| COL4A4 | RAB39B | 0.650592 | 4 | 0 | 3 |
| COL4A4 | RCSD1 | 0.649994 | 4 | 0 | 4 |
| COL4A4 | ADAMTS8 | 0.648433 | 7 | 0 | 6 |
| COL4A4 | SLC22A18AS | 0.645262 | 3 | 0 | 3 |
| COL4A4 | OGN | 0.644327 | 6 | 0 | 6 |
| COL4A4 | PARD3B | 0.6431 | 6 | 0 | 6 |
| COL4A4 | PARM1 | 0.641822 | 8 | 0 | 8 |
For details and further investigation, click here
