| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 8 | Alias Symbol: METH2|FLJ41712|ADAM-TS8 | ||
| Type: protein-coding gene | Cytoband: 11q24.3 | ||
| Entrez ID: 11095 | HGNC ID: HGNC:224 | Ensembl Gene: ENSG00000134917 | OMIM ID: 605175 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS8 | 11095 | 235649_at | -1.4861 | 0.1482 | |
| GSE20347 | ADAMTS8 | 11095 | 220677_s_at | -0.2072 | 0.0138 | |
| GSE23400 | ADAMTS8 | 11095 | 220676_at | -0.2039 | 0.0000 | |
| GSE26886 | ADAMTS8 | 11095 | 235649_at | -0.1136 | 0.5903 | |
| GSE29001 | ADAMTS8 | 11095 | 220676_at | -0.0503 | 0.6510 | |
| GSE38129 | ADAMTS8 | 11095 | 220677_s_at | -0.5052 | 0.0001 | |
| GSE45670 | ADAMTS8 | 11095 | 235649_at | -1.4593 | 0.0000 | |
| GSE53622 | ADAMTS8 | 11095 | 44149 | -2.9294 | 0.0000 | |
| GSE53624 | ADAMTS8 | 11095 | 44149 | -3.2205 | 0.0000 | |
| GSE63941 | ADAMTS8 | 11095 | 235649_at | -3.8014 | 0.0000 | |
| GSE77861 | ADAMTS8 | 11095 | 220677_s_at | -0.1145 | 0.3136 | |
| GSE97050 | ADAMTS8 | 11095 | A_33_P3308347 | -0.9636 | 0.1879 | |
| SRP064894 | ADAMTS8 | 11095 | RNAseq | -0.7342 | 0.1743 | |
| SRP133303 | ADAMTS8 | 11095 | RNAseq | -2.4508 | 0.0000 | |
| SRP159526 | ADAMTS8 | 11095 | RNAseq | -2.0455 | 0.0002 | |
| SRP219564 | ADAMTS8 | 11095 | RNAseq | -0.4177 | 0.7125 | |
| TCGA | ADAMTS8 | 11095 | RNAseq | -1.5370 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by ADAMTS8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS8 | 11095 | 0 | 13 | 17 | |
| GSE20123 | ADAMTS8 | 11095 | 0 | 13 | 17 | |
| GSE43470 | ADAMTS8 | 11095 | 2 | 7 | 34 | |
| GSE46452 | ADAMTS8 | 11095 | 3 | 26 | 30 | |
| GSE47630 | ADAMTS8 | 11095 | 2 | 19 | 19 | |
| GSE54993 | ADAMTS8 | 11095 | 10 | 0 | 60 | |
| GSE54994 | ADAMTS8 | 11095 | 5 | 19 | 29 | |
| GSE60625 | ADAMTS8 | 11095 | 0 | 3 | 8 | |
| GSE74703 | ADAMTS8 | 11095 | 1 | 5 | 30 | |
| GSE74704 | ADAMTS8 | 11095 | 0 | 9 | 11 | |
| TCGA | ADAMTS8 | 11095 | 5 | 50 | 41 |
Total number of gains: 28; Total number of losses: 164; Total Number of normals: 296.
Somatic mutations of ADAMTS8:
Generating mutation plots.
Highly correlated genes for ADAMTS8:
Showing top 20/1485 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS8 | SYNPO2 | 0.834519 | 7 | 0 | 7 |
| ADAMTS8 | CYP21A2 | 0.816237 | 3 | 0 | 3 |
| ADAMTS8 | PLAC9 | 0.809259 | 6 | 0 | 6 |
| ADAMTS8 | SMOC2 | 0.807076 | 5 | 0 | 5 |
| ADAMTS8 | RBPMS2 | 0.80484 | 6 | 0 | 5 |
| ADAMTS8 | ASB5 | 0.79486 | 6 | 0 | 6 |
| ADAMTS8 | ANGPTL1 | 0.792558 | 8 | 0 | 7 |
| ADAMTS8 | ANO5 | 0.78861 | 6 | 0 | 6 |
| ADAMTS8 | FENDRR | 0.788343 | 6 | 0 | 6 |
| ADAMTS8 | LONRF2 | 0.78796 | 5 | 0 | 5 |
| ADAMTS8 | ATP1A2 | 0.785854 | 8 | 0 | 7 |
| ADAMTS8 | MYOCD | 0.780439 | 7 | 0 | 6 |
| ADAMTS8 | LINC01082 | 0.780021 | 6 | 0 | 5 |
| ADAMTS8 | PCP4 | 0.779771 | 8 | 0 | 8 |
| ADAMTS8 | ASPA | 0.77749 | 9 | 0 | 9 |
| ADAMTS8 | CASQ2 | 0.774084 | 9 | 0 | 9 |
| ADAMTS8 | ADAMTS9-AS2 | 0.774077 | 5 | 0 | 5 |
| ADAMTS8 | PGM5 | 0.770832 | 10 | 0 | 10 |
| ADAMTS8 | MAGI2-AS3 | 0.769826 | 5 | 0 | 5 |
| ADAMTS8 | ZNF407 | 0.763037 | 3 | 0 | 3 |
For details and further investigation, click here
