| Full name: clusterin | Alias Symbol: SGP-2|SP-40|TRPM-2|KUB1|CLU1|CLU2 | ||
| Type: protein-coding gene | Cytoband: 8p21.1 | ||
| Entrez ID: 1191 | HGNC ID: HGNC:2095 | Ensembl Gene: ENSG00000120885 | OMIM ID: 185430 |
| Drug and gene relationship at DGIdb | |||
Expression of CLU:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLU | 1191 | 208792_s_at | -1.1989 | 0.3002 | |
| GSE20347 | CLU | 1191 | 208792_s_at | 0.5099 | 0.1822 | |
| GSE23400 | CLU | 1191 | 208791_at | -0.7020 | 0.0014 | |
| GSE26886 | CLU | 1191 | 208792_s_at | 0.5014 | 0.4756 | |
| GSE29001 | CLU | 1191 | 208791_at | 0.2753 | 0.6058 | |
| GSE38129 | CLU | 1191 | 208792_s_at | -0.3203 | 0.4926 | |
| GSE45670 | CLU | 1191 | 208792_s_at | -1.7386 | 0.0002 | |
| GSE53622 | CLU | 1191 | 65044 | -2.0326 | 0.0000 | |
| GSE53624 | CLU | 1191 | 65044 | -1.8011 | 0.0000 | |
| GSE63941 | CLU | 1191 | 208792_s_at | -0.9313 | 0.2795 | |
| GSE77861 | CLU | 1191 | 208792_s_at | 1.2791 | 0.0631 | |
| GSE97050 | CLU | 1191 | A_23_P215913 | -0.2568 | 0.5473 | |
| SRP007169 | CLU | 1191 | RNAseq | -0.6782 | 0.3923 | |
| SRP008496 | CLU | 1191 | RNAseq | -0.4677 | 0.3798 | |
| SRP064894 | CLU | 1191 | RNAseq | -1.2536 | 0.0013 | |
| SRP133303 | CLU | 1191 | RNAseq | -1.8448 | 0.0000 | |
| SRP159526 | CLU | 1191 | RNAseq | -0.8073 | 0.2213 | |
| SRP193095 | CLU | 1191 | RNAseq | 0.3943 | 0.2878 | |
| SRP219564 | CLU | 1191 | RNAseq | -1.1516 | 0.2451 | |
| TCGA | CLU | 1191 | RNAseq | -0.4962 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by CLU expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLU:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLU | 1191 | 5 | 10 | 15 | |
| GSE20123 | CLU | 1191 | 5 | 10 | 15 | |
| GSE43470 | CLU | 1191 | 4 | 7 | 32 | |
| GSE46452 | CLU | 1191 | 13 | 13 | 33 | |
| GSE47630 | CLU | 1191 | 10 | 8 | 22 | |
| GSE54993 | CLU | 1191 | 2 | 15 | 53 | |
| GSE54994 | CLU | 1191 | 10 | 15 | 28 | |
| GSE60625 | CLU | 1191 | 3 | 0 | 8 | |
| GSE74703 | CLU | 1191 | 4 | 6 | 26 | |
| GSE74704 | CLU | 1191 | 4 | 7 | 9 | |
| TCGA | CLU | 1191 | 16 | 43 | 37 |
Total number of gains: 76; Total number of losses: 134; Total Number of normals: 278.
Somatic mutations of CLU:
Generating mutation plots.
Highly correlated genes for CLU:
Showing top 20/766 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLU | CLEC3B | 0.809003 | 3 | 0 | 3 |
| CLU | CYP4V2 | 0.772879 | 3 | 0 | 3 |
| CLU | ANGPTL1 | 0.767937 | 5 | 0 | 5 |
| CLU | XPC | 0.758503 | 3 | 0 | 3 |
| CLU | CYP21A2 | 0.757897 | 3 | 0 | 3 |
| CLU | GPIHBP1 | 0.757236 | 3 | 0 | 3 |
| CLU | PODN | 0.751446 | 4 | 0 | 4 |
| CLU | NR2F1 | 0.738626 | 3 | 0 | 3 |
| CLU | C1RL | 0.73283 | 3 | 0 | 3 |
| CLU | LINC01082 | 0.729684 | 4 | 0 | 4 |
| CLU | GIMAP5 | 0.729502 | 3 | 0 | 3 |
| CLU | CCL14 | 0.729217 | 3 | 0 | 3 |
| CLU | C11orf96 | 0.727783 | 3 | 0 | 3 |
| CLU | PPARG | 0.726552 | 3 | 0 | 3 |
| CLU | OGN | 0.724424 | 7 | 0 | 7 |
| CLU | C7 | 0.723227 | 7 | 0 | 7 |
| CLU | TNFSF12 | 0.72289 | 3 | 0 | 3 |
| CLU | INTS3 | 0.721569 | 3 | 0 | 3 |
| CLU | FGF7 | 0.719616 | 7 | 0 | 7 |
| CLU | CCDC3 | 0.71907 | 5 | 0 | 5 |
For details and further investigation, click here
