| Full name: catechol-O-methyltransferase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 1312 | HGNC ID: HGNC:2228 | Ensembl Gene: ENSG00000093010 | OMIM ID: 116790 |
| Drug and gene relationship at DGIdb | |||
Expression of COMT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COMT | 1312 | 208818_s_at | -0.2537 | 0.5065 | |
| GSE20347 | COMT | 1312 | 208818_s_at | -0.7460 | 0.0003 | |
| GSE23400 | COMT | 1312 | 208818_s_at | 0.0915 | 0.3514 | |
| GSE26886 | COMT | 1312 | 208818_s_at | 0.2296 | 0.2747 | |
| GSE29001 | COMT | 1312 | 208818_s_at | -0.2705 | 0.3930 | |
| GSE38129 | COMT | 1312 | 208818_s_at | -0.2785 | 0.1635 | |
| GSE45670 | COMT | 1312 | 208818_s_at | -0.2323 | 0.2289 | |
| GSE53622 | COMT | 1312 | 82096 | -0.3270 | 0.0001 | |
| GSE53624 | COMT | 1312 | 82096 | -0.2461 | 0.0021 | |
| GSE63941 | COMT | 1312 | 208818_s_at | 0.3813 | 0.5488 | |
| GSE77861 | COMT | 1312 | 208818_s_at | -0.0838 | 0.8422 | |
| GSE97050 | COMT | 1312 | A_23_P251680 | 0.0658 | 0.8486 | |
| SRP007169 | COMT | 1312 | RNAseq | -0.3597 | 0.4010 | |
| SRP008496 | COMT | 1312 | RNAseq | -0.4924 | 0.0593 | |
| SRP064894 | COMT | 1312 | RNAseq | 0.2665 | 0.2920 | |
| SRP133303 | COMT | 1312 | RNAseq | -0.3751 | 0.0264 | |
| SRP159526 | COMT | 1312 | RNAseq | -0.2279 | 0.4625 | |
| SRP193095 | COMT | 1312 | RNAseq | -0.3055 | 0.0605 | |
| SRP219564 | COMT | 1312 | RNAseq | 0.3325 | 0.3675 | |
| TCGA | COMT | 1312 | RNAseq | 0.0633 | 0.1909 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COMT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COMT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COMT | 1312 | 5 | 7 | 18 | |
| GSE20123 | COMT | 1312 | 5 | 7 | 18 | |
| GSE43470 | COMT | 1312 | 4 | 7 | 32 | |
| GSE46452 | COMT | 1312 | 33 | 1 | 25 | |
| GSE47630 | COMT | 1312 | 8 | 5 | 27 | |
| GSE54993 | COMT | 1312 | 3 | 6 | 61 | |
| GSE54994 | COMT | 1312 | 12 | 7 | 34 | |
| GSE60625 | COMT | 1312 | 5 | 0 | 6 | |
| GSE74703 | COMT | 1312 | 4 | 5 | 27 | |
| GSE74704 | COMT | 1312 | 3 | 4 | 13 | |
| TCGA | COMT | 1312 | 27 | 17 | 52 |
Total number of gains: 109; Total number of losses: 66; Total Number of normals: 313.
Somatic mutations of COMT:
Generating mutation plots.
Highly correlated genes for COMT:
Showing top 20/380 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COMT | GRPEL1 | 0.780263 | 3 | 0 | 3 |
| COMT | SPTAN1 | 0.757026 | 3 | 0 | 3 |
| COMT | ERC1 | 0.731605 | 3 | 0 | 3 |
| COMT | MED12 | 0.708735 | 3 | 0 | 3 |
| COMT | GPS2 | 0.698348 | 3 | 0 | 3 |
| COMT | NUDT14 | 0.688708 | 3 | 0 | 3 |
| COMT | ZNF414 | 0.686661 | 3 | 0 | 3 |
| COMT | MOCS2 | 0.684904 | 3 | 0 | 3 |
| COMT | EIF3E | 0.681031 | 3 | 0 | 3 |
| COMT | TBC1D9B | 0.680646 | 3 | 0 | 3 |
| COMT | ZBTB7A | 0.678147 | 3 | 0 | 3 |
| COMT | PLA2G12A | 0.677283 | 4 | 0 | 4 |
| COMT | GHITM | 0.67635 | 3 | 0 | 3 |
| COMT | TMEM18 | 0.673562 | 4 | 0 | 3 |
| COMT | NDUFC1 | 0.670131 | 4 | 0 | 4 |
| COMT | PAQR7 | 0.665217 | 4 | 0 | 4 |
| COMT | AP1B1 | 0.657347 | 6 | 0 | 6 |
| COMT | ARL6IP4 | 0.656606 | 3 | 0 | 3 |
| COMT | TMX4 | 0.656426 | 3 | 0 | 3 |
| COMT | WDR26 | 0.655907 | 4 | 0 | 4 |
For details and further investigation, click here
