| Full name: eukaryotic translation initiation factor 3 subunit E | Alias Symbol: eIF3-p48|eIF3e | ||
| Type: protein-coding gene | Cytoband: 8q23.1 | ||
| Entrez ID: 3646 | HGNC ID: HGNC:3277 | Ensembl Gene: ENSG00000104408 | OMIM ID: 602210 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
EIF3E involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05160 | Hepatitis C |
Expression of EIF3E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF3E | 3646 | 208697_s_at | 0.0455 | 0.9422 | |
| GSE20347 | EIF3E | 3646 | 208697_s_at | 0.1536 | 0.1417 | |
| GSE23400 | EIF3E | 3646 | 208697_s_at | 0.2628 | 0.0008 | |
| GSE26886 | EIF3E | 3646 | 208697_s_at | -0.2622 | 0.2555 | |
| GSE29001 | EIF3E | 3646 | 208697_s_at | -0.1082 | 0.6985 | |
| GSE38129 | EIF3E | 3646 | 208697_s_at | 0.1331 | 0.1408 | |
| GSE45670 | EIF3E | 3646 | 208697_s_at | -0.2033 | 0.0291 | |
| GSE53622 | EIF3E | 3646 | 81964 | 0.0489 | 0.4909 | |
| GSE53624 | EIF3E | 3646 | 81964 | 0.0727 | 0.2640 | |
| GSE63941 | EIF3E | 3646 | 208697_s_at | 0.3916 | 0.2773 | |
| GSE77861 | EIF3E | 3646 | 208697_s_at | -0.0839 | 0.7501 | |
| GSE97050 | EIF3E | 3646 | A_23_P43141 | 0.0084 | 0.9713 | |
| SRP007169 | EIF3E | 3646 | RNAseq | -0.8983 | 0.0181 | |
| SRP008496 | EIF3E | 3646 | RNAseq | -0.7866 | 0.0002 | |
| SRP064894 | EIF3E | 3646 | RNAseq | -0.1220 | 0.5350 | |
| SRP133303 | EIF3E | 3646 | RNAseq | -0.3010 | 0.0219 | |
| SRP159526 | EIF3E | 3646 | RNAseq | -0.6895 | 0.0590 | |
| SRP193095 | EIF3E | 3646 | RNAseq | -0.7799 | 0.0000 | |
| SRP219564 | EIF3E | 3646 | RNAseq | -0.3142 | 0.4745 | |
| TCGA | EIF3E | 3646 | RNAseq | 0.0279 | 0.5294 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF3E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF3E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF3E | 3646 | 16 | 0 | 14 | |
| GSE20123 | EIF3E | 3646 | 17 | 0 | 13 | |
| GSE43470 | EIF3E | 3646 | 22 | 0 | 21 | |
| GSE46452 | EIF3E | 3646 | 25 | 0 | 34 | |
| GSE47630 | EIF3E | 3646 | 24 | 0 | 16 | |
| GSE54993 | EIF3E | 3646 | 0 | 20 | 50 | |
| GSE54994 | EIF3E | 3646 | 37 | 1 | 15 | |
| GSE60625 | EIF3E | 3646 | 0 | 4 | 7 | |
| GSE74703 | EIF3E | 3646 | 19 | 0 | 17 | |
| GSE74704 | EIF3E | 3646 | 11 | 0 | 9 | |
| TCGA | EIF3E | 3646 | 60 | 1 | 35 |
Total number of gains: 231; Total number of losses: 26; Total Number of normals: 231.
Somatic mutations of EIF3E:
Generating mutation plots.
Highly correlated genes for EIF3E:
Showing top 20/280 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF3E | LEPROT | 0.739732 | 3 | 0 | 3 |
| EIF3E | MRPS31 | 0.731427 | 3 | 0 | 3 |
| EIF3E | EBPL | 0.728696 | 3 | 0 | 3 |
| EIF3E | ZNF584 | 0.727863 | 3 | 0 | 3 |
| EIF3E | RABGAP1L | 0.724864 | 3 | 0 | 3 |
| EIF3E | RCHY1 | 0.716439 | 3 | 0 | 3 |
| EIF3E | GPBP1 | 0.715278 | 4 | 0 | 3 |
| EIF3E | CRBN | 0.712203 | 3 | 0 | 3 |
| EIF3E | FASTKD2 | 0.709026 | 3 | 0 | 3 |
| EIF3E | CDK5RAP3 | 0.700847 | 3 | 0 | 3 |
| EIF3E | CWC22 | 0.696574 | 3 | 0 | 3 |
| EIF3E | CPA6 | 0.69454 | 3 | 0 | 3 |
| EIF3E | SMARCAD1 | 0.692435 | 3 | 0 | 3 |
| EIF3E | ZNF292 | 0.686564 | 4 | 0 | 3 |
| EIF3E | COL17A1 | 0.685692 | 3 | 0 | 3 |
| EIF3E | ATP6V1B2 | 0.685648 | 3 | 0 | 3 |
| EIF3E | GLRX2 | 0.68532 | 3 | 0 | 3 |
| EIF3E | IGIP | 0.685029 | 3 | 0 | 3 |
| EIF3E | TM7SF3 | 0.684239 | 3 | 0 | 3 |
| EIF3E | MYOF | 0.682466 | 4 | 0 | 3 |
For details and further investigation, click here
