| Full name: G protein pathway suppressor 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 2874 | HGNC ID: HGNC:4550 | Ensembl Gene: ENSG00000132522 | OMIM ID: 601935 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GPS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPS2 | 2874 | 209350_s_at | -0.1618 | 0.3326 | |
| GSE20347 | GPS2 | 2874 | 209350_s_at | -0.3344 | 0.0072 | |
| GSE23400 | GPS2 | 2874 | 209350_s_at | 0.0631 | 0.3015 | |
| GSE26886 | GPS2 | 2874 | 209350_s_at | -0.0759 | 0.7171 | |
| GSE29001 | GPS2 | 2874 | 209350_s_at | -0.1515 | 0.3813 | |
| GSE38129 | GPS2 | 2874 | 209350_s_at | -0.2809 | 0.0109 | |
| GSE45670 | GPS2 | 2874 | 209350_s_at | 0.0250 | 0.8766 | |
| GSE63941 | GPS2 | 2874 | 209350_s_at | 1.5852 | 0.0007 | |
| GSE77861 | GPS2 | 2874 | 209350_s_at | 0.2840 | 0.1567 | |
| GSE97050 | GPS2 | 2874 | A_33_P3608172 | 0.0129 | 0.9646 | |
| SRP007169 | GPS2 | 2874 | RNAseq | -1.0626 | 0.0063 | |
| SRP008496 | GPS2 | 2874 | RNAseq | -1.2931 | 0.0000 | |
| SRP064894 | GPS2 | 2874 | RNAseq | 0.3521 | 0.0993 | |
| SRP133303 | GPS2 | 2874 | RNAseq | -0.2236 | 0.1464 | |
| SRP159526 | GPS2 | 2874 | RNAseq | 0.4190 | 0.0893 | |
| SRP193095 | GPS2 | 2874 | RNAseq | 0.0846 | 0.4657 | |
| SRP219564 | GPS2 | 2874 | RNAseq | 0.4186 | 0.2845 | |
| TCGA | GPS2 | 2874 | RNAseq | 0.0339 | 0.5101 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by GPS2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GPS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPS2 | 2874 | 4 | 2 | 24 | |
| GSE20123 | GPS2 | 2874 | 4 | 3 | 23 | |
| GSE43470 | GPS2 | 2874 | 1 | 4 | 38 | |
| GSE46452 | GPS2 | 2874 | 34 | 1 | 24 | |
| GSE47630 | GPS2 | 2874 | 7 | 1 | 32 | |
| GSE54993 | GPS2 | 2874 | 4 | 3 | 63 | |
| GSE54994 | GPS2 | 2874 | 5 | 8 | 40 | |
| GSE60625 | GPS2 | 2874 | 4 | 0 | 7 | |
| GSE74703 | GPS2 | 2874 | 1 | 2 | 33 | |
| GSE74704 | GPS2 | 2874 | 2 | 1 | 17 | |
| TCGA | GPS2 | 2874 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of GPS2:
Generating mutation plots.
Highly correlated genes for GPS2:
Showing top 20/179 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPS2 | ZNF548 | 0.795997 | 3 | 0 | 3 |
| GPS2 | SP4 | 0.793102 | 3 | 0 | 3 |
| GPS2 | DNHD1 | 0.776955 | 3 | 0 | 3 |
| GPS2 | RRNAD1 | 0.752097 | 3 | 0 | 3 |
| GPS2 | RHOU | 0.752031 | 3 | 0 | 3 |
| GPS2 | C11orf1 | 0.751241 | 3 | 0 | 3 |
| GPS2 | DEDD | 0.749883 | 3 | 0 | 3 |
| GPS2 | RAD23B | 0.746487 | 3 | 0 | 3 |
| GPS2 | GNG7 | 0.744965 | 3 | 0 | 3 |
| GPS2 | BCL9L | 0.732971 | 3 | 0 | 3 |
| GPS2 | CNOT6 | 0.727008 | 3 | 0 | 3 |
| GPS2 | HES4 | 0.720425 | 3 | 0 | 3 |
| GPS2 | APOLD1 | 0.716539 | 3 | 0 | 3 |
| GPS2 | RABGAP1 | 0.715822 | 4 | 0 | 3 |
| GPS2 | MDH1 | 0.715312 | 3 | 0 | 3 |
| GPS2 | MYEF2 | 0.712874 | 3 | 0 | 3 |
| GPS2 | RPL12 | 0.709639 | 4 | 0 | 4 |
| GPS2 | VEGFB | 0.708718 | 3 | 0 | 3 |
| GPS2 | TNRC18 | 0.707198 | 3 | 0 | 3 |
| GPS2 | JUND | 0.70479 | 3 | 0 | 3 |
For details and further investigation, click here
