| Full name: NADH:ubiquinone oxidoreductase subunit C1 | Alias Symbol: KFYI | ||
| Type: protein-coding gene | Cytoband: 4q31.1 | ||
| Entrez ID: 4717 | HGNC ID: HGNC:7705 | Ensembl Gene: ENSG00000109390 | OMIM ID: 603844 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NDUFC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NDUFC1 | 4717 | 203478_at | -0.2459 | 0.3683 | |
| GSE20347 | NDUFC1 | 4717 | 203478_at | -0.6283 | 0.0000 | |
| GSE23400 | NDUFC1 | 4717 | 203478_at | -0.3360 | 0.0000 | |
| GSE26886 | NDUFC1 | 4717 | 203478_at | -0.2887 | 0.0367 | |
| GSE29001 | NDUFC1 | 4717 | 203478_at | -0.4542 | 0.1292 | |
| GSE38129 | NDUFC1 | 4717 | 203478_at | -0.5005 | 0.0000 | |
| GSE45670 | NDUFC1 | 4717 | 203478_at | -0.2667 | 0.0864 | |
| GSE53622 | NDUFC1 | 4717 | 148603 | -0.7366 | 0.0000 | |
| GSE53624 | NDUFC1 | 4717 | 148603 | -0.5291 | 0.0000 | |
| GSE63941 | NDUFC1 | 4717 | 203478_at | 0.0523 | 0.8813 | |
| GSE77861 | NDUFC1 | 4717 | 203478_at | -0.7144 | 0.0057 | |
| GSE97050 | NDUFC1 | 4717 | A_23_P92362 | -0.4063 | 0.2417 | |
| SRP007169 | NDUFC1 | 4717 | RNAseq | -1.0094 | 0.0078 | |
| SRP008496 | NDUFC1 | 4717 | RNAseq | -0.7467 | 0.0015 | |
| SRP064894 | NDUFC1 | 4717 | RNAseq | -0.4263 | 0.1532 | |
| SRP133303 | NDUFC1 | 4717 | RNAseq | -0.0926 | 0.6939 | |
| SRP159526 | NDUFC1 | 4717 | RNAseq | -0.2259 | 0.3010 | |
| SRP193095 | NDUFC1 | 4717 | RNAseq | -0.6461 | 0.0000 | |
| SRP219564 | NDUFC1 | 4717 | RNAseq | -0.5336 | 0.0500 | |
| TCGA | NDUFC1 | 4717 | RNAseq | -0.0745 | 0.2840 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NDUFC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NDUFC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NDUFC1 | 4717 | 0 | 12 | 18 | |
| GSE20123 | NDUFC1 | 4717 | 0 | 12 | 18 | |
| GSE43470 | NDUFC1 | 4717 | 0 | 13 | 30 | |
| GSE46452 | NDUFC1 | 4717 | 1 | 36 | 22 | |
| GSE47630 | NDUFC1 | 4717 | 0 | 22 | 18 | |
| GSE54993 | NDUFC1 | 4717 | 10 | 0 | 60 | |
| GSE54994 | NDUFC1 | 4717 | 2 | 11 | 40 | |
| GSE60625 | NDUFC1 | 4717 | 0 | 1 | 10 | |
| GSE74703 | NDUFC1 | 4717 | 0 | 11 | 25 | |
| GSE74704 | NDUFC1 | 4717 | 0 | 6 | 14 | |
| TCGA | NDUFC1 | 4717 | 10 | 33 | 53 |
Total number of gains: 23; Total number of losses: 157; Total Number of normals: 308.
Somatic mutations of NDUFC1:
Generating mutation plots.
Highly correlated genes for NDUFC1:
Showing top 20/1341 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NDUFC1 | EIF4E3 | 0.744077 | 5 | 0 | 5 |
| NDUFC1 | CCDC12 | 0.735582 | 5 | 0 | 4 |
| NDUFC1 | KCTD6 | 0.723648 | 5 | 0 | 5 |
| NDUFC1 | TMEM126A | 0.718656 | 3 | 0 | 3 |
| NDUFC1 | FBXO10 | 0.718589 | 4 | 0 | 4 |
| NDUFC1 | RMND5B | 0.712446 | 10 | 0 | 9 |
| NDUFC1 | KIAA1191 | 0.708849 | 6 | 0 | 6 |
| NDUFC1 | MRPS36 | 0.707668 | 6 | 0 | 6 |
| NDUFC1 | ZFAND2B | 0.70415 | 7 | 0 | 6 |
| NDUFC1 | MPP7 | 0.702423 | 7 | 0 | 6 |
| NDUFC1 | CA13 | 0.701223 | 3 | 0 | 3 |
| NDUFC1 | KCNK13 | 0.699916 | 3 | 0 | 3 |
| NDUFC1 | GATM | 0.699456 | 7 | 0 | 6 |
| NDUFC1 | SLTM | 0.696011 | 5 | 0 | 5 |
| NDUFC1 | SLC10A5 | 0.695999 | 3 | 0 | 3 |
| NDUFC1 | PDE12 | 0.695849 | 8 | 0 | 8 |
| NDUFC1 | NMNAT1 | 0.692981 | 5 | 0 | 5 |
| NDUFC1 | PDZK1 | 0.692965 | 3 | 0 | 3 |
| NDUFC1 | RRAGC | 0.692957 | 4 | 0 | 4 |
| NDUFC1 | WDFY2 | 0.689837 | 3 | 0 | 3 |
For details and further investigation, click here
