| Full name: cytochrome c oxidase copper chaperone COX11 | Alias Symbol: COX11P | ||
| Type: protein-coding gene | Cytoband: 17q22 | ||
| Entrez ID: 1353 | HGNC ID: HGNC:2261 | Ensembl Gene: ENSG00000166260 | OMIM ID: 603648 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COX11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX11 | 1353 | 211727_s_at | -0.1375 | 0.8180 | |
| GSE20347 | COX11 | 1353 | 211727_s_at | 0.2592 | 0.1903 | |
| GSE23400 | COX11 | 1353 | 211727_s_at | 0.4646 | 0.0000 | |
| GSE26886 | COX11 | 1353 | 211727_s_at | 0.4999 | 0.0771 | |
| GSE29001 | COX11 | 1353 | 211727_s_at | 0.5238 | 0.1138 | |
| GSE38129 | COX11 | 1353 | 211727_s_at | 0.2716 | 0.1239 | |
| GSE45670 | COX11 | 1353 | 211727_s_at | -0.2154 | 0.1889 | |
| GSE53622 | COX11 | 1353 | 124061 | -0.0476 | 0.4807 | |
| GSE53624 | COX11 | 1353 | 124061 | 0.2402 | 0.0000 | |
| GSE63941 | COX11 | 1353 | 211727_s_at | 0.3808 | 0.2326 | |
| GSE77861 | COX11 | 1353 | 211727_s_at | 0.4928 | 0.1758 | |
| GSE97050 | COX11 | 1353 | A_23_P152666 | -0.1023 | 0.6880 | |
| SRP007169 | COX11 | 1353 | RNAseq | 0.7093 | 0.0952 | |
| SRP008496 | COX11 | 1353 | RNAseq | 0.7022 | 0.0115 | |
| SRP064894 | COX11 | 1353 | RNAseq | 0.0956 | 0.4643 | |
| SRP133303 | COX11 | 1353 | RNAseq | 0.4602 | 0.0806 | |
| SRP159526 | COX11 | 1353 | RNAseq | 0.3640 | 0.1230 | |
| SRP193095 | COX11 | 1353 | RNAseq | -0.2074 | 0.0977 | |
| SRP219564 | COX11 | 1353 | RNAseq | -0.2309 | 0.5261 | |
| TCGA | COX11 | 1353 | RNAseq | -0.1248 | 0.0117 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COX11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX11 | 1353 | 4 | 1 | 25 | |
| GSE20123 | COX11 | 1353 | 4 | 1 | 25 | |
| GSE43470 | COX11 | 1353 | 2 | 1 | 40 | |
| GSE46452 | COX11 | 1353 | 32 | 0 | 27 | |
| GSE47630 | COX11 | 1353 | 7 | 1 | 32 | |
| GSE54993 | COX11 | 1353 | 2 | 4 | 64 | |
| GSE54994 | COX11 | 1353 | 9 | 5 | 39 | |
| GSE60625 | COX11 | 1353 | 4 | 0 | 7 | |
| GSE74703 | COX11 | 1353 | 2 | 1 | 33 | |
| GSE74704 | COX11 | 1353 | 3 | 1 | 16 | |
| TCGA | COX11 | 1353 | 27 | 7 | 62 |
Total number of gains: 96; Total number of losses: 22; Total Number of normals: 370.
Somatic mutations of COX11:
Generating mutation plots.
Highly correlated genes for COX11:
Showing top 20/470 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX11 | CEP97 | 0.769676 | 3 | 0 | 3 |
| COX11 | DCTN6 | 0.724996 | 3 | 0 | 3 |
| COX11 | RIOK1 | 0.721465 | 3 | 0 | 3 |
| COX11 | CHURC1 | 0.719242 | 3 | 0 | 3 |
| COX11 | CSTF3 | 0.711094 | 4 | 0 | 4 |
| COX11 | PPIL4 | 0.705055 | 3 | 0 | 3 |
| COX11 | RIMKLB | 0.704805 | 3 | 0 | 3 |
| COX11 | SGTB | 0.70038 | 4 | 0 | 3 |
| COX11 | TGDS | 0.69389 | 4 | 0 | 3 |
| COX11 | TRIAP1 | 0.68666 | 3 | 0 | 3 |
| COX11 | LRIG3 | 0.686597 | 3 | 0 | 3 |
| COX11 | FNIP1 | 0.682899 | 4 | 0 | 3 |
| COX11 | AGAP1 | 0.679889 | 3 | 0 | 3 |
| COX11 | COMMD2 | 0.67881 | 3 | 0 | 3 |
| COX11 | SLC25A13 | 0.6777 | 3 | 0 | 3 |
| COX11 | MYNN | 0.673832 | 5 | 0 | 4 |
| COX11 | MRPL45 | 0.672645 | 5 | 0 | 4 |
| COX11 | C20orf194 | 0.671704 | 3 | 0 | 3 |
| COX11 | RWDD4 | 0.671296 | 3 | 0 | 3 |
| COX11 | USPL1 | 0.66352 | 4 | 0 | 3 |
For details and further investigation, click here
