| Full name: COMM domain containing 2 | Alias Symbol: HSPC042 | ||
| Type: protein-coding gene | Cytoband: 3q25.1 | ||
| Entrez ID: 51122 | HGNC ID: HGNC:24993 | Ensembl Gene: ENSG00000114744 | OMIM ID: 616699 |
| Drug and gene relationship at DGIdb | |||
Expression of COMMD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COMMD2 | 51122 | 226910_at | 0.2547 | 0.5818 | |
| GSE26886 | COMMD2 | 51122 | 226910_at | -0.0584 | 0.8762 | |
| GSE45670 | COMMD2 | 51122 | 223491_at | 0.8774 | 0.0000 | |
| GSE53622 | COMMD2 | 51122 | 52453 | 0.2901 | 0.0003 | |
| GSE53624 | COMMD2 | 51122 | 52453 | 0.4435 | 0.0000 | |
| GSE63941 | COMMD2 | 51122 | 223491_at | 1.6313 | 0.0012 | |
| GSE77861 | COMMD2 | 51122 | 223491_at | 0.5528 | 0.0285 | |
| GSE97050 | COMMD2 | 51122 | A_23_P40782 | 0.6281 | 0.1383 | |
| SRP007169 | COMMD2 | 51122 | RNAseq | 0.6572 | 0.0387 | |
| SRP008496 | COMMD2 | 51122 | RNAseq | 0.9933 | 0.0000 | |
| SRP064894 | COMMD2 | 51122 | RNAseq | 0.6728 | 0.0004 | |
| SRP133303 | COMMD2 | 51122 | RNAseq | 0.6992 | 0.0000 | |
| SRP159526 | COMMD2 | 51122 | RNAseq | 0.8620 | 0.0030 | |
| SRP193095 | COMMD2 | 51122 | RNAseq | 0.4022 | 0.0041 | |
| SRP219564 | COMMD2 | 51122 | RNAseq | 0.1750 | 0.6300 | |
| TCGA | COMMD2 | 51122 | RNAseq | 0.2363 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by COMMD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COMMD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COMMD2 | 51122 | 22 | 0 | 8 | |
| GSE20123 | COMMD2 | 51122 | 22 | 0 | 8 | |
| GSE43470 | COMMD2 | 51122 | 23 | 0 | 20 | |
| GSE46452 | COMMD2 | 51122 | 18 | 2 | 39 | |
| GSE47630 | COMMD2 | 51122 | 19 | 3 | 18 | |
| GSE54993 | COMMD2 | 51122 | 1 | 10 | 59 | |
| GSE54994 | COMMD2 | 51122 | 37 | 1 | 15 | |
| GSE60625 | COMMD2 | 51122 | 0 | 6 | 5 | |
| GSE74703 | COMMD2 | 51122 | 20 | 0 | 16 | |
| GSE74704 | COMMD2 | 51122 | 15 | 0 | 5 | |
| TCGA | COMMD2 | 51122 | 72 | 1 | 23 |
Total number of gains: 249; Total number of losses: 23; Total Number of normals: 216.
Somatic mutations of COMMD2:
Generating mutation plots.
Highly correlated genes for COMMD2:
Showing top 20/1293 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COMMD2 | PCYT1A | 0.870355 | 3 | 0 | 3 |
| COMMD2 | LRRC58 | 0.816367 | 4 | 0 | 4 |
| COMMD2 | RPP38 | 0.81595 | 3 | 0 | 3 |
| COMMD2 | FARS2 | 0.81227 | 3 | 0 | 3 |
| COMMD2 | FAM32A | 0.804382 | 4 | 0 | 4 |
| COMMD2 | ALKBH6 | 0.803358 | 3 | 0 | 3 |
| COMMD2 | SPNS1 | 0.795316 | 4 | 0 | 4 |
| COMMD2 | MKRN1 | 0.792886 | 3 | 0 | 3 |
| COMMD2 | CNOT10 | 0.785018 | 3 | 0 | 3 |
| COMMD2 | PPP1CA | 0.783639 | 3 | 0 | 3 |
| COMMD2 | U2SURP | 0.782231 | 4 | 0 | 4 |
| COMMD2 | CRKL | 0.782219 | 4 | 0 | 4 |
| COMMD2 | PEMT | 0.778671 | 3 | 0 | 3 |
| COMMD2 | AP2M1 | 0.777992 | 5 | 0 | 5 |
| COMMD2 | WDR77 | 0.774243 | 3 | 0 | 3 |
| COMMD2 | MFHAS1 | 0.766951 | 5 | 0 | 5 |
| COMMD2 | TRMT12 | 0.766686 | 4 | 0 | 4 |
| COMMD2 | TEAD4 | 0.762276 | 4 | 0 | 4 |
| COMMD2 | ZSCAN12 | 0.762194 | 3 | 0 | 3 |
| COMMD2 | ADAM17 | 0.761214 | 4 | 0 | 4 |
For details and further investigation, click here
