| Full name: DEAD-box helicase 18 | Alias Symbol: MrDb|Has1 | ||
| Type: protein-coding gene | Cytoband: 2q14.1 | ||
| Entrez ID: 8886 | HGNC ID: HGNC:2741 | Ensembl Gene: ENSG00000088205 | OMIM ID: 606355 |
| Drug and gene relationship at DGIdb | |||
Expression of DDX18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX18 | 8886 | 208895_s_at | 0.8773 | 0.0684 | |
| GSE20347 | DDX18 | 8886 | 208895_s_at | 0.6001 | 0.0001 | |
| GSE23400 | DDX18 | 8886 | 208897_s_at | 0.5592 | 0.0000 | |
| GSE26886 | DDX18 | 8886 | 208897_s_at | 0.0907 | 0.5874 | |
| GSE29001 | DDX18 | 8886 | 208895_s_at | 0.4698 | 0.0144 | |
| GSE38129 | DDX18 | 8886 | 208895_s_at | 0.6525 | 0.0000 | |
| GSE45670 | DDX18 | 8886 | 208896_at | 0.1784 | 0.2432 | |
| GSE53622 | DDX18 | 8886 | 14156 | 0.0881 | 0.2283 | |
| GSE53624 | DDX18 | 8886 | 14156 | 0.3696 | 0.0000 | |
| GSE63941 | DDX18 | 8886 | 208895_s_at | 1.0851 | 0.0004 | |
| GSE77861 | DDX18 | 8886 | 208895_s_at | 0.8302 | 0.0039 | |
| GSE97050 | DDX18 | 8886 | A_33_P3235340 | -0.0417 | 0.9041 | |
| SRP007169 | DDX18 | 8886 | RNAseq | 1.0631 | 0.0032 | |
| SRP008496 | DDX18 | 8886 | RNAseq | 1.3659 | 0.0000 | |
| SRP064894 | DDX18 | 8886 | RNAseq | 0.3751 | 0.0387 | |
| SRP133303 | DDX18 | 8886 | RNAseq | 0.3900 | 0.0007 | |
| SRP159526 | DDX18 | 8886 | RNAseq | 0.4486 | 0.1396 | |
| SRP193095 | DDX18 | 8886 | RNAseq | 0.3741 | 0.0028 | |
| SRP219564 | DDX18 | 8886 | RNAseq | -0.0823 | 0.7941 | |
| TCGA | DDX18 | 8886 | RNAseq | 0.1836 | 0.0003 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DDX18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX18 | 8886 | 4 | 2 | 24 | |
| GSE20123 | DDX18 | 8886 | 5 | 2 | 23 | |
| GSE43470 | DDX18 | 8886 | 3 | 1 | 39 | |
| GSE46452 | DDX18 | 8886 | 1 | 4 | 54 | |
| GSE47630 | DDX18 | 8886 | 6 | 0 | 34 | |
| GSE54993 | DDX18 | 8886 | 0 | 6 | 64 | |
| GSE54994 | DDX18 | 8886 | 11 | 0 | 42 | |
| GSE60625 | DDX18 | 8886 | 0 | 3 | 8 | |
| GSE74703 | DDX18 | 8886 | 3 | 1 | 32 | |
| GSE74704 | DDX18 | 8886 | 3 | 2 | 15 | |
| TCGA | DDX18 | 8886 | 32 | 6 | 58 |
Total number of gains: 68; Total number of losses: 27; Total Number of normals: 393.
Somatic mutations of DDX18:
Generating mutation plots.
Highly correlated genes for DDX18:
Showing top 20/1430 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX18 | PACSIN3 | 0.811866 | 3 | 0 | 3 |
| DDX18 | TPD52 | 0.777639 | 3 | 0 | 3 |
| DDX18 | DDX59 | 0.772083 | 3 | 0 | 3 |
| DDX18 | ALKBH6 | 0.77091 | 3 | 0 | 3 |
| DDX18 | RICTOR | 0.767924 | 3 | 0 | 3 |
| DDX18 | EPB41L5 | 0.763986 | 3 | 0 | 3 |
| DDX18 | NAA25 | 0.747135 | 4 | 0 | 3 |
| DDX18 | LEMD2 | 0.741359 | 3 | 0 | 3 |
| DDX18 | YWHAG | 0.732654 | 4 | 0 | 4 |
| DDX18 | PMF1 | 0.73253 | 3 | 0 | 3 |
| DDX18 | PANK4 | 0.731247 | 4 | 0 | 3 |
| DDX18 | CEP250 | 0.730506 | 4 | 0 | 4 |
| DDX18 | SMARCC1 | 0.730292 | 3 | 0 | 3 |
| DDX18 | ABHD3 | 0.725875 | 3 | 0 | 3 |
| DDX18 | LRRC58 | 0.723525 | 4 | 0 | 3 |
| DDX18 | TADA1 | 0.723459 | 3 | 0 | 3 |
| DDX18 | DDX55 | 0.723089 | 5 | 0 | 4 |
| DDX18 | EPPK1 | 0.722941 | 5 | 0 | 5 |
| DDX18 | IPO9 | 0.721726 | 8 | 0 | 7 |
| DDX18 | SAMD1 | 0.72098 | 4 | 0 | 3 |
For details and further investigation, click here
