IDH1

 

Full name: isocitrate dehydrogenase (NADP(+)) 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 2q34
Entrez ID: 3417 HGNC ID: HGNC:5382 Ensembl Gene: ENSG00000138413 OMIM ID: 147700
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of IDH1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IDH1 3417 201193_at -0.1238 0.8837
GSE20347 IDH1 3417 201193_at -0.4516 0.0464
GSE23400 IDH1 3417 201193_at -0.0641 0.6609
GSE26886 IDH1 3417 201193_at -0.7824 0.0009
GSE29001 IDH1 3417 201193_at -0.3263 0.4225
GSE38129 IDH1 3417 201193_at -0.0804 0.7154
GSE45670 IDH1 3417 201193_at -0.0456 0.8889
GSE63941 IDH1 3417 201193_at 0.1740 0.7925
GSE77861 IDH1 3417 201193_at -0.1808 0.6129
GSE97050 IDH1 3417 A_32_P45009 0.1124 0.8225
SRP007169 IDH1 3417 RNAseq 0.2674 0.4245
SRP008496 IDH1 3417 RNAseq -0.1805 0.4456
SRP064894 IDH1 3417 RNAseq -0.3512 0.0723
SRP133303 IDH1 3417 RNAseq -0.2761 0.0810
SRP159526 IDH1 3417 RNAseq 0.2226 0.6151
SRP193095 IDH1 3417 RNAseq -0.6623 0.0026
SRP219564 IDH1 3417 RNAseq -0.4151 0.4679
TCGA IDH1 3417 RNAseq 0.0216 0.7630

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IDH1 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of IDH1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IDH1 3417 3 10 17
GSE20123 IDH1 3417 3 10 17
GSE43470 IDH1 3417 2 4 37
GSE46452 IDH1 3417 0 5 54
GSE47630 IDH1 3417 4 5 31
GSE54993 IDH1 3417 0 3 67
GSE54994 IDH1 3417 9 9 35
GSE60625 IDH1 3417 0 3 8
GSE74703 IDH1 3417 2 3 31
GSE74704 IDH1 3417 2 5 13
TCGA IDH1 3417 15 20 61

Total number of gains: 40; Total number of losses: 77; Total Number of normals: 371.  

 

Somatic mutations of IDH1:

 

Generating mutation plots.

 

Highly correlated genes for IDH1:

 

Showing top 20/363 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IDH1TMEM1540.796974303
IDH1BTBD110.7328404
IDH1DENND2C0.705504303
IDH1C15orf480.703529303
IDH1MACC10.69686303
IDH1C6orf1320.692367303
IDH1TMEM190.686741303
IDH1LPAR50.674036404
IDH1MED70.665804303
IDH1SLC38A90.662078303
IDH1COX5B0.660091303
IDH1IMPACT0.658681404
IDH1CERS30.656714403
IDH1OSBPL80.654143303
IDH1TECR0.653967505
IDH1SMIM70.652787404
IDH1S100A160.649229403
IDH1ABHD17C0.646888303
IDH1BNIPL0.645336303
IDH1SERINC50.636676906

For details and further investigation, click here