| Full name: cysteinyl-tRNA synthetase 2, mitochondrial | Alias Symbol: FLJ12118 | ||
| Type: protein-coding gene | Cytoband: 13q34 | ||
| Entrez ID: 79587 | HGNC ID: HGNC:25695 | Ensembl Gene: ENSG00000134905 | OMIM ID: 612800 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CARS2 | 79587 | 218153_at | 0.2634 | 0.4443 | |
| GSE20347 | CARS2 | 79587 | 218153_at | 0.1560 | 0.6551 | |
| GSE23400 | CARS2 | 79587 | 218153_at | 0.0051 | 0.9517 | |
| GSE26886 | CARS2 | 79587 | 218153_at | 0.1128 | 0.6327 | |
| GSE29001 | CARS2 | 79587 | 218153_at | -0.2758 | 0.3266 | |
| GSE38129 | CARS2 | 79587 | 218153_at | 0.0116 | 0.9628 | |
| GSE45670 | CARS2 | 79587 | 218153_at | 0.0306 | 0.8710 | |
| GSE53622 | CARS2 | 79587 | 58113 | -0.1162 | 0.1421 | |
| GSE53624 | CARS2 | 79587 | 58113 | 0.0319 | 0.6837 | |
| GSE63941 | CARS2 | 79587 | 218153_at | -0.7785 | 0.1070 | |
| GSE77861 | CARS2 | 79587 | 218153_at | -0.1469 | 0.4998 | |
| GSE97050 | CARS2 | 79587 | A_23_P128624 | -0.0891 | 0.7642 | |
| SRP007169 | CARS2 | 79587 | RNAseq | -0.5631 | 0.1179 | |
| SRP008496 | CARS2 | 79587 | RNAseq | -0.1880 | 0.4054 | |
| SRP064894 | CARS2 | 79587 | RNAseq | 0.4589 | 0.0375 | |
| SRP133303 | CARS2 | 79587 | RNAseq | 0.1116 | 0.3188 | |
| SRP159526 | CARS2 | 79587 | RNAseq | -0.1243 | 0.6484 | |
| SRP193095 | CARS2 | 79587 | RNAseq | 0.0330 | 0.7475 | |
| SRP219564 | CARS2 | 79587 | RNAseq | 0.2890 | 0.4060 | |
| TCGA | CARS2 | 79587 | RNAseq | -0.0125 | 0.8319 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CARS2 | 79587 | 6 | 11 | 13 | |
| GSE20123 | CARS2 | 79587 | 6 | 10 | 14 | |
| GSE43470 | CARS2 | 79587 | 4 | 13 | 26 | |
| GSE46452 | CARS2 | 79587 | 2 | 31 | 26 | |
| GSE47630 | CARS2 | 79587 | 3 | 26 | 11 | |
| GSE54993 | CARS2 | 79587 | 11 | 4 | 55 | |
| GSE54994 | CARS2 | 79587 | 8 | 8 | 37 | |
| GSE60625 | CARS2 | 79587 | 0 | 3 | 8 | |
| GSE74703 | CARS2 | 79587 | 3 | 9 | 24 | |
| GSE74704 | CARS2 | 79587 | 4 | 9 | 7 | |
| TCGA | CARS2 | 79587 | 19 | 33 | 44 |
Total number of gains: 66; Total number of losses: 157; Total Number of normals: 265.
Somatic mutations of CARS2:
Generating mutation plots.
Highly correlated genes for CARS2:
Showing top 20/216 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CARS2 | UTP23 | 0.811194 | 3 | 0 | 3 |
| CARS2 | GLRX2 | 0.786517 | 3 | 0 | 3 |
| CARS2 | PPP1R37 | 0.760745 | 3 | 0 | 3 |
| CARS2 | ZNF7 | 0.760287 | 3 | 0 | 3 |
| CARS2 | ANKRD46 | 0.742789 | 3 | 0 | 3 |
| CARS2 | COPS5 | 0.740543 | 3 | 0 | 3 |
| CARS2 | NPHP3 | 0.734261 | 3 | 0 | 3 |
| CARS2 | C2orf49 | 0.727777 | 3 | 0 | 3 |
| CARS2 | ZNF529 | 0.726463 | 3 | 0 | 3 |
| CARS2 | ZNF251 | 0.725683 | 3 | 0 | 3 |
| CARS2 | RFNG | 0.711589 | 3 | 0 | 3 |
| CARS2 | C2orf76 | 0.710098 | 3 | 0 | 3 |
| CARS2 | PUS3 | 0.709385 | 3 | 0 | 3 |
| CARS2 | NCOA6 | 0.700527 | 3 | 0 | 3 |
| CARS2 | UPF1 | 0.697093 | 3 | 0 | 3 |
| CARS2 | DAB2IP | 0.695793 | 3 | 0 | 3 |
| CARS2 | ICA1L | 0.689259 | 3 | 0 | 3 |
| CARS2 | MRFAP1 | 0.688524 | 4 | 0 | 3 |
| CARS2 | TSEN15 | 0.685405 | 3 | 0 | 3 |
| CARS2 | PAN3 | 0.684755 | 3 | 0 | 3 |
For details and further investigation, click here
