| Full name: carnitine O-acetyltransferase | Alias Symbol: CAT1 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 1384 | HGNC ID: HGNC:2342 | Ensembl Gene: ENSG00000095321 | OMIM ID: 600184 |
| Drug and gene relationship at DGIdb | |||
Expression of CRAT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRAT | 1384 | 209522_s_at | -1.3603 | 0.0075 | |
| GSE20347 | CRAT | 1384 | 205843_x_at | -0.4052 | 0.0003 | |
| GSE23400 | CRAT | 1384 | 205843_x_at | -0.4592 | 0.0000 | |
| GSE26886 | CRAT | 1384 | 209522_s_at | -0.2038 | 0.6632 | |
| GSE29001 | CRAT | 1384 | 209522_s_at | -1.1522 | 0.0007 | |
| GSE38129 | CRAT | 1384 | 205843_x_at | -0.5070 | 0.0000 | |
| GSE45670 | CRAT | 1384 | 209522_s_at | -0.5913 | 0.0234 | |
| GSE53622 | CRAT | 1384 | 123997 | -0.4621 | 0.0000 | |
| GSE53624 | CRAT | 1384 | 123997 | -0.2647 | 0.0001 | |
| GSE63941 | CRAT | 1384 | 205843_x_at | -0.4838 | 0.0468 | |
| GSE77861 | CRAT | 1384 | 205843_x_at | -0.1129 | 0.4035 | |
| GSE97050 | CRAT | 1384 | A_33_P3280531 | -0.1981 | 0.4288 | |
| SRP007169 | CRAT | 1384 | RNAseq | -1.8445 | 0.0136 | |
| SRP008496 | CRAT | 1384 | RNAseq | -1.9202 | 0.0000 | |
| SRP064894 | CRAT | 1384 | RNAseq | -0.3000 | 0.3512 | |
| SRP133303 | CRAT | 1384 | RNAseq | -2.0262 | 0.0000 | |
| SRP159526 | CRAT | 1384 | RNAseq | -0.5619 | 0.3898 | |
| SRP193095 | CRAT | 1384 | RNAseq | -0.6680 | 0.0035 | |
| SRP219564 | CRAT | 1384 | RNAseq | -1.6554 | 0.0111 | |
| TCGA | CRAT | 1384 | RNAseq | -0.4797 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by CRAT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRAT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRAT | 1384 | 6 | 9 | 15 | |
| GSE20123 | CRAT | 1384 | 6 | 9 | 15 | |
| GSE43470 | CRAT | 1384 | 5 | 8 | 30 | |
| GSE46452 | CRAT | 1384 | 6 | 13 | 40 | |
| GSE47630 | CRAT | 1384 | 3 | 16 | 21 | |
| GSE54993 | CRAT | 1384 | 3 | 3 | 64 | |
| GSE54994 | CRAT | 1384 | 11 | 8 | 34 | |
| GSE60625 | CRAT | 1384 | 0 | 0 | 11 | |
| GSE74703 | CRAT | 1384 | 5 | 6 | 25 | |
| GSE74704 | CRAT | 1384 | 3 | 7 | 10 | |
| TCGA | CRAT | 1384 | 27 | 25 | 44 |
Total number of gains: 75; Total number of losses: 104; Total Number of normals: 309.
Somatic mutations of CRAT:
Generating mutation plots.
Highly correlated genes for CRAT:
Showing top 20/571 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRAT | AIFM2 | 0.710459 | 3 | 0 | 3 |
| CRAT | SLC7A4 | 0.694935 | 6 | 0 | 6 |
| CRAT | ZNF524 | 0.693398 | 3 | 0 | 3 |
| CRAT | ANKRD33 | 0.683947 | 3 | 0 | 3 |
| CRAT | CAB39L | 0.670575 | 8 | 0 | 7 |
| CRAT | CCDC169 | 0.665554 | 3 | 0 | 3 |
| CRAT | GLYCTK | 0.663036 | 3 | 0 | 3 |
| CRAT | CDRT15L2 | 0.66155 | 3 | 0 | 3 |
| CRAT | LINC00312 | 0.659216 | 3 | 0 | 3 |
| CRAT | INSRR | 0.654079 | 4 | 0 | 3 |
| CRAT | NUCB2 | 0.647285 | 7 | 0 | 6 |
| CRAT | GJC2 | 0.644861 | 6 | 0 | 5 |
| CRAT | C5 | 0.641679 | 3 | 0 | 3 |
| CRAT | PSCA | 0.639489 | 7 | 0 | 6 |
| CRAT | NT5M | 0.639178 | 3 | 0 | 3 |
| CRAT | RXFP3 | 0.637198 | 6 | 0 | 6 |
| CRAT | FNDC4 | 0.635529 | 9 | 0 | 7 |
| CRAT | CHRNA3 | 0.634537 | 3 | 0 | 3 |
| CRAT | CRISP3 | 0.633829 | 7 | 0 | 5 |
| CRAT | FAM95B1 | 0.633123 | 3 | 0 | 3 |
For details and further investigation, click here
