| Full name: complement C5 | Alias Symbol: CPAMD4|C5a|C5b | ||
| Type: protein-coding gene | Cytoband: 9q33.2 | ||
| Entrez ID: 727 | HGNC ID: HGNC:1331 | Ensembl Gene: ENSG00000106804 | OMIM ID: 120900 |
| Drug and gene relationship at DGIdb | |||
C5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05133 | Pertussis | |
| hsa05150 | Staphylococcus aureus infection |
Expression of C5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C5 | 727 | 205500_at | -0.5699 | 0.1907 | |
| GSE20347 | C5 | 727 | 205500_at | -0.1531 | 0.3615 | |
| GSE23400 | C5 | 727 | 205500_at | -0.0463 | 0.3747 | |
| GSE26886 | C5 | 727 | 205500_at | 0.2004 | 0.4540 | |
| GSE29001 | C5 | 727 | 205500_at | -0.2428 | 0.6285 | |
| GSE38129 | C5 | 727 | 205500_at | -0.3277 | 0.0931 | |
| GSE45670 | C5 | 727 | 205500_at | -0.7020 | 0.0084 | |
| GSE53622 | C5 | 727 | 85499 | -0.4139 | 0.0099 | |
| GSE53624 | C5 | 727 | 85499 | -0.4379 | 0.0008 | |
| GSE63941 | C5 | 727 | 205500_at | -0.8082 | 0.4222 | |
| GSE77861 | C5 | 727 | 205500_at | 0.0192 | 0.9411 | |
| GSE97050 | C5 | 727 | A_23_P71855 | 0.1568 | 0.5713 | |
| SRP007169 | C5 | 727 | RNAseq | 0.1941 | 0.7840 | |
| SRP064894 | C5 | 727 | RNAseq | 0.0454 | 0.8937 | |
| SRP133303 | C5 | 727 | RNAseq | -0.1978 | 0.2699 | |
| SRP159526 | C5 | 727 | RNAseq | -0.1397 | 0.7693 | |
| SRP193095 | C5 | 727 | RNAseq | -0.2334 | 0.2888 | |
| SRP219564 | C5 | 727 | RNAseq | -0.6111 | 0.0485 | |
| TCGA | C5 | 727 | RNAseq | -0.7096 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by C5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C5 | 727 | 3 | 7 | 20 | |
| GSE20123 | C5 | 727 | 3 | 7 | 20 | |
| GSE43470 | C5 | 727 | 5 | 4 | 34 | |
| GSE46452 | C5 | 727 | 6 | 13 | 40 | |
| GSE47630 | C5 | 727 | 3 | 16 | 21 | |
| GSE54993 | C5 | 727 | 3 | 3 | 64 | |
| GSE54994 | C5 | 727 | 9 | 10 | 34 | |
| GSE60625 | C5 | 727 | 0 | 0 | 11 | |
| GSE74703 | C5 | 727 | 5 | 3 | 28 | |
| GSE74704 | C5 | 727 | 2 | 5 | 13 | |
| TCGA | C5 | 727 | 27 | 26 | 43 |
Total number of gains: 66; Total number of losses: 94; Total Number of normals: 328.
Somatic mutations of C5:
Generating mutation plots.
Highly correlated genes for C5:
Showing top 20/235 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C5 | TSPAN31 | 0.714489 | 3 | 0 | 3 |
| C5 | GALNT11 | 0.713709 | 3 | 0 | 3 |
| C5 | RASSF3 | 0.696172 | 3 | 0 | 3 |
| C5 | ANAPC16 | 0.68504 | 4 | 0 | 4 |
| C5 | DNAJB14 | 0.679181 | 3 | 0 | 3 |
| C5 | SGTB | 0.676095 | 3 | 0 | 3 |
| C5 | ELL3 | 0.674707 | 4 | 0 | 3 |
| C5 | PCNT | 0.668272 | 3 | 0 | 3 |
| C5 | TMEM43 | 0.66134 | 3 | 0 | 3 |
| C5 | UGGT2 | 0.660784 | 4 | 0 | 3 |
| C5 | PIK3CA | 0.656977 | 3 | 0 | 3 |
| C5 | TUBGCP3 | 0.65526 | 4 | 0 | 3 |
| C5 | MYCT1 | 0.651182 | 3 | 0 | 3 |
| C5 | ZNF844 | 0.650478 | 3 | 0 | 3 |
| C5 | CUEDC1 | 0.645735 | 3 | 0 | 3 |
| C5 | C11orf68 | 0.645058 | 3 | 0 | 3 |
| C5 | CHAMP1 | 0.644947 | 4 | 0 | 3 |
| C5 | EIF3K | 0.644748 | 3 | 0 | 3 |
| C5 | TBC1D5 | 0.644651 | 4 | 0 | 3 |
| C5 | ZCCHC8 | 0.64366 | 3 | 0 | 3 |
For details and further investigation, click here
