| Full name: prostate stem cell antigen | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 8000 | HGNC ID: HGNC:9500 | Ensembl Gene: ENSG00000167653 | OMIM ID: 602470 |
| Drug and gene relationship at DGIdb | |||
Expression of PSCA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSCA | 8000 | 205319_at | -3.7368 | 0.0430 | |
| GSE20347 | PSCA | 8000 | 205319_at | -3.2862 | 0.0000 | |
| GSE23400 | PSCA | 8000 | 205319_at | -2.7331 | 0.0000 | |
| GSE26886 | PSCA | 8000 | 205319_at | -3.2447 | 0.0000 | |
| GSE29001 | PSCA | 8000 | 205319_at | -2.1660 | 0.0000 | |
| GSE38129 | PSCA | 8000 | 205319_at | -2.9535 | 0.0000 | |
| GSE45670 | PSCA | 8000 | 205319_at | -1.2237 | 0.0581 | |
| GSE63941 | PSCA | 8000 | 205319_at | 1.5884 | 0.3963 | |
| GSE77861 | PSCA | 8000 | 205319_at | -2.0870 | 0.0123 | |
| SRP007169 | PSCA | 8000 | RNAseq | -5.5315 | 0.0000 | |
| SRP008496 | PSCA | 8000 | RNAseq | -5.1042 | 0.0000 | |
| SRP064894 | PSCA | 8000 | RNAseq | -3.4345 | 0.0000 | |
| SRP133303 | PSCA | 8000 | RNAseq | -4.6615 | 0.0000 | |
| SRP159526 | PSCA | 8000 | RNAseq | -6.1391 | 0.0000 | |
| SRP193095 | PSCA | 8000 | RNAseq | -3.8805 | 0.0000 | |
| SRP219564 | PSCA | 8000 | RNAseq | -3.8163 | 0.0005 | |
| TCGA | PSCA | 8000 | RNAseq | -2.2067 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by PSCA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PSCA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSCA | 8000 | 16 | 1 | 13 | |
| GSE20123 | PSCA | 8000 | 17 | 1 | 12 | |
| GSE43470 | PSCA | 8000 | 17 | 2 | 24 | |
| GSE46452 | PSCA | 8000 | 27 | 0 | 32 | |
| GSE47630 | PSCA | 8000 | 23 | 1 | 16 | |
| GSE54993 | PSCA | 8000 | 0 | 25 | 45 | |
| GSE54994 | PSCA | 8000 | 39 | 1 | 13 | |
| GSE60625 | PSCA | 8000 | 3 | 4 | 4 | |
| GSE74703 | PSCA | 8000 | 15 | 1 | 20 | |
| GSE74704 | PSCA | 8000 | 10 | 0 | 10 | |
| TCGA | PSCA | 8000 | 63 | 2 | 31 |
Total number of gains: 230; Total number of losses: 38; Total Number of normals: 220.
Somatic mutations of PSCA:
Generating mutation plots.
Highly correlated genes for PSCA:
Showing top 20/1490 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSCA | SFTA2 | 0.883194 | 4 | 0 | 4 |
| PSCA | SCNN1B | 0.878347 | 9 | 0 | 9 |
| PSCA | ATG9B | 0.874406 | 4 | 0 | 4 |
| PSCA | CRISP3 | 0.870607 | 8 | 0 | 8 |
| PSCA | GYS2 | 0.870195 | 8 | 0 | 8 |
| PSCA | HCG22 | 0.861957 | 4 | 0 | 4 |
| PSCA | MXD1 | 0.860763 | 8 | 0 | 8 |
| PSCA | BNIPL | 0.85547 | 4 | 0 | 4 |
| PSCA | SASH1 | 0.853955 | 8 | 0 | 8 |
| PSCA | TMPRSS11B | 0.850005 | 4 | 0 | 4 |
| PSCA | RMND5B | 0.848634 | 8 | 0 | 8 |
| PSCA | FCHO2 | 0.848541 | 4 | 0 | 4 |
| PSCA | FLG | 0.847753 | 8 | 0 | 8 |
| PSCA | IL36A | 0.84735 | 8 | 0 | 8 |
| PSCA | UBL3 | 0.845487 | 8 | 0 | 8 |
| PSCA | SPINK7 | 0.844353 | 4 | 0 | 4 |
| PSCA | AIF1L | 0.841593 | 4 | 0 | 4 |
| PSCA | RANBP9 | 0.8412 | 8 | 0 | 8 |
| PSCA | FUT6 | 0.840764 | 9 | 0 | 9 |
| PSCA | PRSS3 | 0.840763 | 8 | 0 | 8 |
For details and further investigation, click here
