| Full name: apoptosis inducing factor mitochondria associated 2 | Alias Symbol: FLJ14497|PRG3 | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 84883 | HGNC ID: HGNC:21411 | Ensembl Gene: ENSG00000042286 | OMIM ID: 605159 |
| Drug and gene relationship at DGIdb | |||
Expression of AIFM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AIFM2 | 84883 | 224461_s_at | -1.0689 | 0.1842 | |
| GSE26886 | AIFM2 | 84883 | 224461_s_at | -1.5739 | 0.0007 | |
| GSE45670 | AIFM2 | 84883 | 224461_s_at | -1.1364 | 0.0001 | |
| GSE53622 | AIFM2 | 84883 | 24191 | -0.9303 | 0.0000 | |
| GSE53624 | AIFM2 | 84883 | 24191 | -0.3016 | 0.0028 | |
| GSE63941 | AIFM2 | 84883 | 224461_s_at | -0.3591 | 0.7217 | |
| GSE77861 | AIFM2 | 84883 | 228445_at | -0.1000 | 0.4560 | |
| GSE97050 | AIFM2 | 84883 | A_33_P3319231 | -0.4400 | 0.1922 | |
| SRP007169 | AIFM2 | 84883 | RNAseq | -2.1824 | 0.0000 | |
| SRP064894 | AIFM2 | 84883 | RNAseq | -1.7046 | 0.0000 | |
| SRP133303 | AIFM2 | 84883 | RNAseq | -0.5524 | 0.0022 | |
| SRP159526 | AIFM2 | 84883 | RNAseq | -0.7386 | 0.1089 | |
| SRP193095 | AIFM2 | 84883 | RNAseq | -0.3543 | 0.0175 | |
| SRP219564 | AIFM2 | 84883 | RNAseq | -0.8406 | 0.0636 | |
| TCGA | AIFM2 | 84883 | RNAseq | -0.0295 | 0.7231 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by AIFM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AIFM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AIFM2 | 84883 | 2 | 4 | 24 | |
| GSE20123 | AIFM2 | 84883 | 2 | 3 | 25 | |
| GSE43470 | AIFM2 | 84883 | 1 | 7 | 35 | |
| GSE46452 | AIFM2 | 84883 | 0 | 11 | 48 | |
| GSE47630 | AIFM2 | 84883 | 2 | 14 | 24 | |
| GSE54993 | AIFM2 | 84883 | 7 | 0 | 63 | |
| GSE54994 | AIFM2 | 84883 | 2 | 12 | 39 | |
| GSE60625 | AIFM2 | 84883 | 0 | 0 | 11 | |
| GSE74703 | AIFM2 | 84883 | 1 | 4 | 31 | |
| GSE74704 | AIFM2 | 84883 | 1 | 1 | 18 | |
| TCGA | AIFM2 | 84883 | 9 | 23 | 64 |
Total number of gains: 27; Total number of losses: 79; Total Number of normals: 382.
Somatic mutations of AIFM2:
Generating mutation plots.
Highly correlated genes for AIFM2:
Showing top 20/708 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AIFM2 | FDX1 | 0.78953 | 3 | 0 | 3 |
| AIFM2 | ATP6V1C2 | 0.761028 | 3 | 0 | 3 |
| AIFM2 | PSCA | 0.74201 | 3 | 0 | 3 |
| AIFM2 | SLC46A2 | 0.738355 | 5 | 0 | 5 |
| AIFM2 | SFTA2 | 0.733138 | 3 | 0 | 3 |
| AIFM2 | ARSG | 0.731973 | 3 | 0 | 3 |
| AIFM2 | CPPED1 | 0.728332 | 5 | 0 | 5 |
| AIFM2 | ALDH3A2 | 0.728154 | 5 | 0 | 5 |
| AIFM2 | GSTT2 | 0.72743 | 3 | 0 | 3 |
| AIFM2 | PAQR8 | 0.716346 | 5 | 0 | 5 |
| AIFM2 | LRRC20 | 0.714759 | 4 | 0 | 3 |
| AIFM2 | PADI1 | 0.714518 | 3 | 0 | 3 |
| AIFM2 | ASAP3 | 0.711044 | 4 | 0 | 4 |
| AIFM2 | CRAT | 0.710459 | 3 | 0 | 3 |
| AIFM2 | FNDC4 | 0.709229 | 4 | 0 | 4 |
| AIFM2 | RMND5B | 0.709043 | 5 | 0 | 4 |
| AIFM2 | SPNS2 | 0.706924 | 3 | 0 | 3 |
| AIFM2 | ATG9B | 0.705149 | 3 | 0 | 3 |
| AIFM2 | VSIG2 | 0.704221 | 4 | 0 | 4 |
| AIFM2 | SLC8A1-AS1 | 0.700204 | 4 | 0 | 4 |
For details and further investigation, click here
