| Full name: insulin receptor related receptor | Alias Symbol: IRR | ||
| Type: protein-coding gene | Cytoband: 1q23.1 | ||
| Entrez ID: 3645 | HGNC ID: HGNC:6093 | Ensembl Gene: ENSG00000027644 | OMIM ID: 147671 |
| Drug and gene relationship at DGIdb | |||
INSRR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05215 | Prostate cancer |
Expression of INSRR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INSRR | 3645 | 215776_at | -0.2366 | 0.2721 | |
| GSE20347 | INSRR | 3645 | 215776_at | 0.0606 | 0.4763 | |
| GSE23400 | INSRR | 3645 | 215776_at | -0.0750 | 0.0287 | |
| GSE26886 | INSRR | 3645 | 215776_at | 0.0909 | 0.5873 | |
| GSE29001 | INSRR | 3645 | 215776_at | -0.0624 | 0.7294 | |
| GSE38129 | INSRR | 3645 | 215776_at | -0.0301 | 0.6665 | |
| GSE45670 | INSRR | 3645 | 215776_at | 0.1164 | 0.2117 | |
| GSE53622 | INSRR | 3645 | 9603 | -0.2978 | 0.0028 | |
| GSE53624 | INSRR | 3645 | 9603 | -0.2649 | 0.0060 | |
| GSE63941 | INSRR | 3645 | 215776_at | 0.0777 | 0.6707 | |
| GSE77861 | INSRR | 3645 | 215776_at | -0.0436 | 0.7975 | |
| GSE97050 | INSRR | 3645 | A_23_P615 | -0.0722 | 0.8397 | |
| TCGA | INSRR | 3645 | RNAseq | -3.1073 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by INSRR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INSRR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INSRR | 3645 | 11 | 0 | 19 | |
| GSE20123 | INSRR | 3645 | 11 | 0 | 19 | |
| GSE43470 | INSRR | 3645 | 7 | 2 | 34 | |
| GSE46452 | INSRR | 3645 | 2 | 1 | 56 | |
| GSE47630 | INSRR | 3645 | 14 | 0 | 26 | |
| GSE54993 | INSRR | 3645 | 0 | 5 | 65 | |
| GSE54994 | INSRR | 3645 | 16 | 0 | 37 | |
| GSE60625 | INSRR | 3645 | 0 | 0 | 11 | |
| GSE74703 | INSRR | 3645 | 7 | 2 | 27 | |
| GSE74704 | INSRR | 3645 | 6 | 0 | 14 | |
| TCGA | INSRR | 3645 | 38 | 2 | 56 |
Total number of gains: 112; Total number of losses: 12; Total Number of normals: 364.
Somatic mutations of INSRR:
Generating mutation plots.
Highly correlated genes for INSRR:
Showing top 20/727 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INSRR | GSTT2 | 0.830368 | 3 | 0 | 3 |
| INSRR | ZNF358 | 0.80263 | 3 | 0 | 3 |
| INSRR | ADRB1 | 0.778786 | 3 | 0 | 3 |
| INSRR | C2CD4B | 0.775329 | 3 | 0 | 3 |
| INSRR | RNF185 | 0.765924 | 3 | 0 | 3 |
| INSRR | PSKH1 | 0.753751 | 3 | 0 | 3 |
| INSRR | RNLS | 0.739488 | 3 | 0 | 3 |
| INSRR | CHADL | 0.73894 | 3 | 0 | 3 |
| INSRR | GPRC5B | 0.733243 | 3 | 0 | 3 |
| INSRR | DERL3 | 0.731455 | 3 | 0 | 3 |
| INSRR | HMGN5 | 0.729982 | 3 | 0 | 3 |
| INSRR | GNG7 | 0.729825 | 3 | 0 | 3 |
| INSRR | KLF4 | 0.72693 | 3 | 0 | 3 |
| INSRR | ATG10 | 0.715673 | 5 | 0 | 5 |
| INSRR | TNFSF8 | 0.713707 | 4 | 0 | 4 |
| INSRR | ALDH1L2 | 0.708562 | 3 | 0 | 3 |
| INSRR | PHLDB1 | 0.707963 | 6 | 0 | 6 |
| INSRR | ABCA3 | 0.701671 | 3 | 0 | 3 |
| INSRR | RNF31 | 0.701504 | 4 | 0 | 3 |
| INSRR | RHOBTB2 | 0.700845 | 3 | 0 | 3 |
For details and further investigation, click here
