| Full name: nucleobindin 2 | Alias Symbol: NEFA | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 4925 | HGNC ID: HGNC:8044 | Ensembl Gene: ENSG00000070081 | OMIM ID: 608020 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NUCB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUCB2 | 4925 | 203675_at | -2.1170 | 0.0147 | |
| GSE20347 | NUCB2 | 4925 | 203675_at | -2.6663 | 0.0000 | |
| GSE23400 | NUCB2 | 4925 | 203675_at | -2.3355 | 0.0000 | |
| GSE26886 | NUCB2 | 4925 | 203675_at | -2.0410 | 0.0000 | |
| GSE29001 | NUCB2 | 4925 | 203675_at | -2.9794 | 0.0000 | |
| GSE38129 | NUCB2 | 4925 | 203675_at | -2.2353 | 0.0000 | |
| GSE45670 | NUCB2 | 4925 | 203675_at | -1.5422 | 0.0002 | |
| GSE53622 | NUCB2 | 4925 | 158784 | -2.2466 | 0.0000 | |
| GSE53624 | NUCB2 | 4925 | 158784 | -2.2275 | 0.0000 | |
| GSE63941 | NUCB2 | 4925 | 203675_at | -1.7924 | 0.0070 | |
| GSE77861 | NUCB2 | 4925 | 203675_at | -2.4062 | 0.0046 | |
| GSE97050 | NUCB2 | 4925 | A_23_P13364 | -1.2105 | 0.1012 | |
| SRP007169 | NUCB2 | 4925 | RNAseq | -3.7075 | 0.0000 | |
| SRP008496 | NUCB2 | 4925 | RNAseq | -3.2568 | 0.0000 | |
| SRP064894 | NUCB2 | 4925 | RNAseq | -2.0981 | 0.0000 | |
| SRP133303 | NUCB2 | 4925 | RNAseq | -1.8378 | 0.0000 | |
| SRP159526 | NUCB2 | 4925 | RNAseq | -2.1921 | 0.0000 | |
| SRP193095 | NUCB2 | 4925 | RNAseq | -2.6442 | 0.0000 | |
| SRP219564 | NUCB2 | 4925 | RNAseq | -1.9667 | 0.0001 | |
| TCGA | NUCB2 | 4925 | RNAseq | -0.4495 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 18.
Survival by NUCB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUCB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUCB2 | 4925 | 0 | 10 | 20 | |
| GSE20123 | NUCB2 | 4925 | 0 | 10 | 20 | |
| GSE43470 | NUCB2 | 4925 | 1 | 5 | 37 | |
| GSE46452 | NUCB2 | 4925 | 7 | 5 | 47 | |
| GSE47630 | NUCB2 | 4925 | 3 | 10 | 27 | |
| GSE54993 | NUCB2 | 4925 | 3 | 0 | 67 | |
| GSE54994 | NUCB2 | 4925 | 3 | 13 | 37 | |
| GSE60625 | NUCB2 | 4925 | 0 | 0 | 11 | |
| GSE74703 | NUCB2 | 4925 | 1 | 3 | 32 | |
| GSE74704 | NUCB2 | 4925 | 0 | 9 | 11 | |
| TCGA | NUCB2 | 4925 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 94; Total Number of normals: 365.
Somatic mutations of NUCB2:
Generating mutation plots.
Highly correlated genes for NUCB2:
Showing top 20/1538 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUCB2 | KRT78 | 0.888197 | 7 | 0 | 7 |
| NUCB2 | RANBP9 | 0.884764 | 11 | 0 | 11 |
| NUCB2 | SFTA2 | 0.87936 | 4 | 0 | 4 |
| NUCB2 | CRISP3 | 0.873892 | 11 | 0 | 11 |
| NUCB2 | GYS2 | 0.863353 | 10 | 0 | 10 |
| NUCB2 | EPS8L2 | 0.845968 | 10 | 0 | 10 |
| NUCB2 | PMM1 | 0.843299 | 11 | 0 | 11 |
| NUCB2 | GDPD3 | 0.843095 | 11 | 0 | 11 |
| NUCB2 | RMND5B | 0.838981 | 11 | 0 | 11 |
| NUCB2 | SASH1 | 0.838949 | 12 | 0 | 11 |
| NUCB2 | GBP6 | 0.837832 | 4 | 0 | 4 |
| NUCB2 | PHACTR2 | 0.835778 | 11 | 0 | 11 |
| NUCB2 | HCG22 | 0.834316 | 6 | 0 | 6 |
| NUCB2 | FAM214A | 0.833419 | 6 | 0 | 6 |
| NUCB2 | VSIG2 | 0.832045 | 7 | 0 | 7 |
| NUCB2 | FCHO2 | 0.831147 | 7 | 0 | 7 |
| NUCB2 | CXCR2 | 0.826855 | 11 | 0 | 11 |
| NUCB2 | MGLL | 0.826792 | 12 | 0 | 11 |
| NUCB2 | ETFDH | 0.826784 | 11 | 0 | 11 |
| NUCB2 | UBL3 | 0.826039 | 12 | 0 | 11 |
For details and further investigation, click here
