| Full name: cholinergic receptor nicotinic alpha 3 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q25.1 | ||
| Entrez ID: 1136 | HGNC ID: HGNC:1957 | Ensembl Gene: ENSG00000080644 | OMIM ID: 118503 |
| Drug and gene relationship at DGIdb | |||
CHRNA3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04725 | Cholinergic synapse |
Expression of CHRNA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNA3 | 1136 | 211587_x_at | -0.1570 | 0.3549 | |
| GSE20347 | CHRNA3 | 1136 | 211587_x_at | 0.0728 | 0.6387 | |
| GSE23400 | CHRNA3 | 1136 | 211587_x_at | -0.1554 | 0.0000 | |
| GSE26886 | CHRNA3 | 1136 | 211587_x_at | -0.1157 | 0.2696 | |
| GSE29001 | CHRNA3 | 1136 | 211587_x_at | -0.2807 | 0.0527 | |
| GSE38129 | CHRNA3 | 1136 | 211587_x_at | -0.0418 | 0.7445 | |
| GSE45670 | CHRNA3 | 1136 | 211587_x_at | 0.3055 | 0.2629 | |
| GSE53622 | CHRNA3 | 1136 | 69725 | 0.4860 | 0.0004 | |
| GSE53624 | CHRNA3 | 1136 | 69725 | 0.9550 | 0.0000 | |
| GSE63941 | CHRNA3 | 1136 | 211587_x_at | 0.1455 | 0.3932 | |
| GSE77861 | CHRNA3 | 1136 | 211587_x_at | -0.0745 | 0.4968 | |
| GSE97050 | CHRNA3 | 1136 | A_33_P3388147 | 0.3435 | 0.4518 | |
| SRP133303 | CHRNA3 | 1136 | RNAseq | 0.5562 | 0.1736 | |
| SRP159526 | CHRNA3 | 1136 | RNAseq | 1.2721 | 0.0779 | |
| TCGA | CHRNA3 | 1136 | RNAseq | -0.6385 | 0.0287 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHRNA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNA3 | 1136 | 7 | 1 | 22 | |
| GSE20123 | CHRNA3 | 1136 | 7 | 1 | 22 | |
| GSE43470 | CHRNA3 | 1136 | 4 | 5 | 34 | |
| GSE46452 | CHRNA3 | 1136 | 3 | 7 | 49 | |
| GSE47630 | CHRNA3 | 1136 | 8 | 10 | 22 | |
| GSE54993 | CHRNA3 | 1136 | 5 | 6 | 59 | |
| GSE54994 | CHRNA3 | 1136 | 5 | 6 | 42 | |
| GSE60625 | CHRNA3 | 1136 | 4 | 0 | 7 | |
| GSE74703 | CHRNA3 | 1136 | 4 | 3 | 29 | |
| GSE74704 | CHRNA3 | 1136 | 3 | 1 | 16 | |
| TCGA | CHRNA3 | 1136 | 14 | 15 | 67 |
Total number of gains: 64; Total number of losses: 55; Total Number of normals: 369.
Somatic mutations of CHRNA3:
Generating mutation plots.
Highly correlated genes for CHRNA3:
Showing top 20/529 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNA3 | ZMAT4 | 0.708898 | 4 | 0 | 4 |
| CHRNA3 | IL1RAPL2 | 0.702771 | 4 | 0 | 4 |
| CHRNA3 | ESRRB | 0.701123 | 3 | 0 | 3 |
| CHRNA3 | IFNA21 | 0.69291 | 6 | 0 | 6 |
| CHRNA3 | IFNA17 | 0.684171 | 5 | 0 | 5 |
| CHRNA3 | SERPINA5 | 0.67303 | 3 | 0 | 3 |
| CHRNA3 | OR10J1 | 0.667762 | 4 | 0 | 4 |
| CHRNA3 | CHRM2 | 0.66755 | 4 | 0 | 4 |
| CHRNA3 | CGA | 0.667545 | 4 | 0 | 4 |
| CHRNA3 | OR6A2 | 0.667244 | 4 | 0 | 4 |
| CHRNA3 | HHLA1 | 0.663254 | 4 | 0 | 4 |
| CHRNA3 | OR10H3 | 0.660007 | 7 | 0 | 6 |
| CHRNA3 | G6PC2 | 0.659209 | 6 | 0 | 5 |
| CHRNA3 | GPSM3 | 0.658296 | 4 | 0 | 4 |
| CHRNA3 | KRTAP5-9 | 0.657802 | 5 | 0 | 5 |
| CHRNA3 | GDF10 | 0.656231 | 4 | 0 | 4 |
| CHRNA3 | KHDRBS2 | 0.651393 | 4 | 0 | 4 |
| CHRNA3 | OR2J2 | 0.649624 | 3 | 0 | 3 |
| CHRNA3 | MTAP | 0.649373 | 5 | 0 | 4 |
| CHRNA3 | PRL | 0.648136 | 7 | 0 | 7 |
For details and further investigation, click here
