| Full name: solute carrier family 7 member 4 | Alias Symbol: HCAT3|CAT-4|VH | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 6545 | HGNC ID: HGNC:11062 | Ensembl Gene: ENSG00000099960 | OMIM ID: 603752 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC7A4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC7A4 | 6545 | 205864_at | -0.9545 | 0.0956 | |
| GSE20347 | SLC7A4 | 6545 | 205864_at | -0.8973 | 0.0000 | |
| GSE23400 | SLC7A4 | 6545 | 205864_at | -0.5769 | 0.0000 | |
| GSE26886 | SLC7A4 | 6545 | 214406_s_at | 0.0244 | 0.8576 | |
| GSE29001 | SLC7A4 | 6545 | 205864_at | -0.8284 | 0.0011 | |
| GSE38129 | SLC7A4 | 6545 | 205864_at | -0.7081 | 0.0000 | |
| GSE45670 | SLC7A4 | 6545 | 214406_s_at | -0.0402 | 0.6738 | |
| GSE53622 | SLC7A4 | 6545 | 40272 | -1.8923 | 0.0000 | |
| GSE53624 | SLC7A4 | 6545 | 40272 | -2.3137 | 0.0000 | |
| GSE63941 | SLC7A4 | 6545 | 214406_s_at | 0.3887 | 0.0957 | |
| GSE77861 | SLC7A4 | 6545 | 205864_at | -0.4901 | 0.0732 | |
| SRP007169 | SLC7A4 | 6545 | RNAseq | -3.2975 | 0.0000 | |
| SRP064894 | SLC7A4 | 6545 | RNAseq | -2.7504 | 0.0000 | |
| SRP133303 | SLC7A4 | 6545 | RNAseq | -2.7613 | 0.0000 | |
| SRP159526 | SLC7A4 | 6545 | RNAseq | -2.7943 | 0.0040 | |
| SRP193095 | SLC7A4 | 6545 | RNAseq | -1.8685 | 0.0000 | |
| TCGA | SLC7A4 | 6545 | RNAseq | -0.2206 | 0.6834 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by SLC7A4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC7A4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC7A4 | 6545 | 6 | 7 | 17 | |
| GSE20123 | SLC7A4 | 6545 | 6 | 7 | 17 | |
| GSE43470 | SLC7A4 | 6545 | 3 | 7 | 33 | |
| GSE46452 | SLC7A4 | 6545 | 33 | 1 | 25 | |
| GSE47630 | SLC7A4 | 6545 | 8 | 5 | 27 | |
| GSE54993 | SLC7A4 | 6545 | 3 | 6 | 61 | |
| GSE54994 | SLC7A4 | 6545 | 11 | 7 | 35 | |
| GSE60625 | SLC7A4 | 6545 | 5 | 0 | 6 | |
| GSE74703 | SLC7A4 | 6545 | 3 | 5 | 28 | |
| GSE74704 | SLC7A4 | 6545 | 3 | 4 | 13 | |
| TCGA | SLC7A4 | 6545 | 27 | 17 | 52 |
Total number of gains: 108; Total number of losses: 66; Total Number of normals: 314.
Somatic mutations of SLC7A4:
Generating mutation plots.
Highly correlated genes for SLC7A4:
Showing top 20/1208 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC7A4 | LINC00330 | 0.809464 | 3 | 0 | 3 |
| SLC7A4 | FLG-AS1 | 0.809276 | 3 | 0 | 3 |
| SLC7A4 | SLC35C1 | 0.800616 | 8 | 0 | 8 |
| SLC7A4 | TCP11L2 | 0.798817 | 3 | 0 | 3 |
| SLC7A4 | SLURP1 | 0.796644 | 8 | 0 | 8 |
| SLC7A4 | PRSS27 | 0.787681 | 4 | 0 | 4 |
| SLC7A4 | ULK3 | 0.785288 | 4 | 0 | 4 |
| SLC7A4 | ANXA9 | 0.785203 | 8 | 0 | 8 |
| SLC7A4 | FAM3D | 0.783071 | 4 | 0 | 4 |
| SLC7A4 | SCNN1B | 0.780053 | 8 | 0 | 8 |
| SLC7A4 | ENDOU | 0.778328 | 8 | 0 | 8 |
| SLC7A4 | RMND5B | 0.777458 | 8 | 0 | 8 |
| SLC7A4 | CLIC3 | 0.77591 | 6 | 0 | 6 |
| SLC7A4 | CYSRT1 | 0.775421 | 4 | 0 | 4 |
| SLC7A4 | SPINK7 | 0.773744 | 4 | 0 | 4 |
| SLC7A4 | EPS8L1 | 0.772091 | 8 | 0 | 8 |
| SLC7A4 | ATP13A4 | 0.769775 | 4 | 0 | 4 |
| SLC7A4 | UPK1A | 0.768572 | 8 | 0 | 8 |
| SLC7A4 | FLG | 0.768354 | 7 | 0 | 7 |
| SLC7A4 | FNDC4 | 0.765116 | 8 | 0 | 8 |
For details and further investigation, click here
