| Full name: trefoil factor 1 | Alias Symbol: D21S21|HPS2|pS2|pNR-2|HP1.A | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 7031 | HGNC ID: HGNC:11755 | Ensembl Gene: ENSG00000160182 | OMIM ID: 113710 |
| Drug and gene relationship at DGIdb | |||
Expression of TFF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TFF1 | 7031 | 205009_at | -1.0130 | 0.2351 | |
| GSE20347 | TFF1 | 7031 | 205009_at | -0.1284 | 0.3406 | |
| GSE23400 | TFF1 | 7031 | 205009_at | -0.6321 | 0.0066 | |
| GSE26886 | TFF1 | 7031 | 205009_at | 0.5444 | 0.2621 | |
| GSE29001 | TFF1 | 7031 | 205009_at | -0.0152 | 0.9497 | |
| GSE38129 | TFF1 | 7031 | 205009_at | -0.8519 | 0.0792 | |
| GSE45670 | TFF1 | 7031 | 205009_at | -1.1062 | 0.0665 | |
| GSE53622 | TFF1 | 7031 | 52434 | -1.2288 | 0.0002 | |
| GSE53624 | TFF1 | 7031 | 52434 | -1.7420 | 0.0000 | |
| GSE63941 | TFF1 | 7031 | 205009_at | 0.3514 | 0.7646 | |
| GSE77861 | TFF1 | 7031 | 205009_at | -0.0737 | 0.5253 | |
| GSE97050 | TFF1 | 7031 | A_24_P322771 | -0.0022 | 0.9926 | |
| TCGA | TFF1 | 7031 | RNAseq | -4.0269 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TFF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TFF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TFF1 | 7031 | 2 | 8 | 20 | |
| GSE20123 | TFF1 | 7031 | 2 | 8 | 20 | |
| GSE43470 | TFF1 | 7031 | 0 | 13 | 30 | |
| GSE46452 | TFF1 | 7031 | 1 | 21 | 37 | |
| GSE47630 | TFF1 | 7031 | 6 | 17 | 17 | |
| GSE54993 | TFF1 | 7031 | 8 | 1 | 61 | |
| GSE54994 | TFF1 | 7031 | 3 | 8 | 42 | |
| GSE60625 | TFF1 | 7031 | 0 | 0 | 11 | |
| GSE74703 | TFF1 | 7031 | 0 | 10 | 26 | |
| GSE74704 | TFF1 | 7031 | 1 | 4 | 15 | |
| TCGA | TFF1 | 7031 | 7 | 40 | 49 |
Total number of gains: 30; Total number of losses: 130; Total Number of normals: 328.
Somatic mutations of TFF1:
Generating mutation plots.
Highly correlated genes for TFF1:
Showing top 20/218 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TFF1 | KSR1 | 0.809995 | 3 | 0 | 3 |
| TFF1 | FAAH2 | 0.765251 | 3 | 0 | 3 |
| TFF1 | C6orf58 | 0.763098 | 5 | 0 | 5 |
| TFF1 | SSTR5-AS1 | 0.755161 | 4 | 0 | 3 |
| TFF1 | SLC6A3 | 0.745865 | 3 | 0 | 3 |
| TFF1 | FXYD2 | 0.744234 | 3 | 0 | 3 |
| TFF1 | NME8 | 0.743603 | 3 | 0 | 3 |
| TFF1 | LRTM1 | 0.739786 | 3 | 0 | 3 |
| TFF1 | FOLR1 | 0.737509 | 3 | 0 | 3 |
| TFF1 | C9orf152 | 0.732955 | 5 | 0 | 5 |
| TFF1 | CAPN8 | 0.732006 | 5 | 0 | 4 |
| TFF1 | GP2 | 0.718414 | 6 | 0 | 5 |
| TFF1 | MYBPH | 0.716541 | 3 | 0 | 3 |
| TFF1 | LRRC31 | 0.715146 | 8 | 0 | 7 |
| TFF1 | SCGB3A1 | 0.712307 | 4 | 0 | 4 |
| TFF1 | GH1 | 0.704832 | 3 | 0 | 3 |
| TFF1 | KIR3DL3 | 0.704094 | 3 | 0 | 3 |
| TFF1 | TFF2 | 0.703459 | 10 | 0 | 8 |
| TFF1 | GKN1 | 0.699392 | 7 | 0 | 6 |
| TFF1 | NPPA | 0.694999 | 3 | 0 | 3 |
For details and further investigation, click here
