| Full name: uridine-cytidine kinase 1 | Alias Symbol: URK1|FLJ12255 | ||
| Type: protein-coding gene | Cytoband: 9q34.13 | ||
| Entrez ID: 83549 | HGNC ID: HGNC:14859 | Ensembl Gene: ENSG00000130717 | OMIM ID: 609328 |
| Drug and gene relationship at DGIdb | |||
Expression of UCK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UCK1 | 83549 | 223141_at | -0.1128 | 0.7743 | |
| GSE26886 | UCK1 | 83549 | 223141_at | -0.2068 | 0.1428 | |
| GSE45670 | UCK1 | 83549 | 223141_at | -0.1695 | 0.1747 | |
| GSE53622 | UCK1 | 83549 | 128527 | 0.2234 | 0.0003 | |
| GSE53624 | UCK1 | 83549 | 128527 | 0.2956 | 0.0000 | |
| GSE63941 | UCK1 | 83549 | 223141_at | -0.5887 | 0.0563 | |
| GSE77861 | UCK1 | 83549 | 223141_at | -0.1495 | 0.3144 | |
| GSE97050 | UCK1 | 83549 | A_23_P216402 | 0.0875 | 0.6435 | |
| SRP007169 | UCK1 | 83549 | RNAseq | -0.2429 | 0.5325 | |
| SRP008496 | UCK1 | 83549 | RNAseq | -0.2703 | 0.2653 | |
| SRP064894 | UCK1 | 83549 | RNAseq | 0.3690 | 0.1776 | |
| SRP133303 | UCK1 | 83549 | RNAseq | -0.0379 | 0.8109 | |
| SRP159526 | UCK1 | 83549 | RNAseq | 0.4160 | 0.0951 | |
| SRP193095 | UCK1 | 83549 | RNAseq | -0.1041 | 0.3736 | |
| SRP219564 | UCK1 | 83549 | RNAseq | -0.5267 | 0.1650 | |
| TCGA | UCK1 | 83549 | RNAseq | -0.1130 | 0.0577 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UCK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UCK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UCK1 | 83549 | 6 | 9 | 15 | |
| GSE20123 | UCK1 | 83549 | 6 | 9 | 15 | |
| GSE43470 | UCK1 | 83549 | 5 | 7 | 31 | |
| GSE46452 | UCK1 | 83549 | 6 | 13 | 40 | |
| GSE47630 | UCK1 | 83549 | 3 | 16 | 21 | |
| GSE54993 | UCK1 | 83549 | 3 | 3 | 64 | |
| GSE54994 | UCK1 | 83549 | 12 | 9 | 32 | |
| GSE60625 | UCK1 | 83549 | 0 | 0 | 11 | |
| GSE74703 | UCK1 | 83549 | 5 | 5 | 26 | |
| GSE74704 | UCK1 | 83549 | 3 | 7 | 10 | |
| TCGA | UCK1 | 83549 | 28 | 26 | 42 |
Total number of gains: 77; Total number of losses: 104; Total Number of normals: 307.
Somatic mutations of UCK1:
Generating mutation plots.
Highly correlated genes for UCK1:
Showing top 20/74 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UCK1 | TFE3 | 0.769669 | 3 | 0 | 3 |
| UCK1 | LRFN2 | 0.756588 | 3 | 0 | 3 |
| UCK1 | BEND7 | 0.749521 | 3 | 0 | 3 |
| UCK1 | CALCOCO1 | 0.719931 | 4 | 0 | 3 |
| UCK1 | VAMP4 | 0.70955 | 3 | 0 | 3 |
| UCK1 | WDR45 | 0.707267 | 4 | 0 | 4 |
| UCK1 | FAM110B | 0.705408 | 3 | 0 | 3 |
| UCK1 | CYB561D2 | 0.704813 | 3 | 0 | 3 |
| UCK1 | SMPX | 0.703519 | 3 | 0 | 3 |
| UCK1 | CRTC1 | 0.698286 | 3 | 0 | 3 |
| UCK1 | DMGDH | 0.697025 | 3 | 0 | 3 |
| UCK1 | FERD3L | 0.690475 | 3 | 0 | 3 |
| UCK1 | TSNAXIP1 | 0.689811 | 3 | 0 | 3 |
| UCK1 | FOXO4 | 0.681066 | 3 | 0 | 3 |
| UCK1 | PGPEP1 | 0.679635 | 3 | 0 | 3 |
| UCK1 | OTUD5 | 0.672701 | 3 | 0 | 3 |
| UCK1 | PPM1F | 0.67217 | 3 | 0 | 3 |
| UCK1 | RAB17 | 0.668741 | 4 | 0 | 3 |
| UCK1 | DOK7 | 0.668699 | 3 | 0 | 3 |
| UCK1 | CHD5 | 0.666477 | 4 | 0 | 4 |
For details and further investigation, click here
