| Full name: serine palmitoyltransferase long chain base subunit 1 | Alias Symbol: LCB1|SPTI|HSAN1|hLCB1 | ||
| Type: protein-coding gene | Cytoband: 9q22.31 | ||
| Entrez ID: 10558 | HGNC ID: HGNC:11277 | Ensembl Gene: ENSG00000090054 | OMIM ID: 605712 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPTLC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPTLC1 | 10558 | 202277_at | -0.4221 | 0.4413 | |
| GSE20347 | SPTLC1 | 10558 | 202277_at | -0.7293 | 0.0000 | |
| GSE23400 | SPTLC1 | 10558 | 202277_at | -0.3853 | 0.0002 | |
| GSE26886 | SPTLC1 | 10558 | 202277_at | -1.4906 | 0.0000 | |
| GSE29001 | SPTLC1 | 10558 | 202277_at | -0.4247 | 0.0538 | |
| GSE38129 | SPTLC1 | 10558 | 202277_at | -0.3386 | 0.0222 | |
| GSE45670 | SPTLC1 | 10558 | 202277_at | -0.3314 | 0.0269 | |
| GSE53622 | SPTLC1 | 10558 | 22534 | -0.8730 | 0.0000 | |
| GSE53624 | SPTLC1 | 10558 | 22534 | -1.1808 | 0.0000 | |
| GSE63941 | SPTLC1 | 10558 | 202277_at | -0.2154 | 0.5759 | |
| GSE77861 | SPTLC1 | 10558 | 202277_at | -0.8686 | 0.0027 | |
| GSE97050 | SPTLC1 | 10558 | A_23_P43326 | -0.2013 | 0.6530 | |
| SRP007169 | SPTLC1 | 10558 | RNAseq | -1.4502 | 0.0001 | |
| SRP008496 | SPTLC1 | 10558 | RNAseq | -1.3919 | 0.0000 | |
| SRP064894 | SPTLC1 | 10558 | RNAseq | -0.7621 | 0.0000 | |
| SRP133303 | SPTLC1 | 10558 | RNAseq | -0.2196 | 0.2697 | |
| SRP159526 | SPTLC1 | 10558 | RNAseq | -0.8758 | 0.0027 | |
| SRP193095 | SPTLC1 | 10558 | RNAseq | -0.9055 | 0.0000 | |
| SRP219564 | SPTLC1 | 10558 | RNAseq | -0.8526 | 0.0629 | |
| TCGA | SPTLC1 | 10558 | RNAseq | 0.0765 | 0.1051 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by SPTLC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPTLC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPTLC1 | 10558 | 6 | 9 | 15 | |
| GSE20123 | SPTLC1 | 10558 | 6 | 9 | 15 | |
| GSE43470 | SPTLC1 | 10558 | 6 | 4 | 33 | |
| GSE46452 | SPTLC1 | 10558 | 6 | 14 | 39 | |
| GSE47630 | SPTLC1 | 10558 | 1 | 18 | 21 | |
| GSE54993 | SPTLC1 | 10558 | 4 | 2 | 64 | |
| GSE54994 | SPTLC1 | 10558 | 8 | 11 | 34 | |
| GSE60625 | SPTLC1 | 10558 | 0 | 0 | 11 | |
| GSE74703 | SPTLC1 | 10558 | 5 | 3 | 28 | |
| GSE74704 | SPTLC1 | 10558 | 3 | 7 | 10 | |
| TCGA | SPTLC1 | 10558 | 22 | 24 | 50 |
Total number of gains: 67; Total number of losses: 101; Total Number of normals: 320.
Somatic mutations of SPTLC1:
Generating mutation plots.
Highly correlated genes for SPTLC1:
Showing top 20/1395 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPTLC1 | ANKRD44 | 0.831017 | 3 | 0 | 3 |
| SPTLC1 | CCNYL1 | 0.80177 | 5 | 0 | 5 |
| SPTLC1 | CCDC25 | 0.798742 | 3 | 0 | 3 |
| SPTLC1 | ZNF823 | 0.798446 | 7 | 0 | 7 |
| SPTLC1 | EPG5 | 0.784757 | 4 | 0 | 4 |
| SPTLC1 | TAB3 | 0.781948 | 7 | 0 | 7 |
| SPTLC1 | SLC46A2 | 0.772198 | 7 | 0 | 7 |
| SPTLC1 | KIAA0355 | 0.771116 | 3 | 0 | 3 |
| SPTLC1 | CAPN14 | 0.769791 | 6 | 0 | 6 |
| SPTLC1 | RHBDL2 | 0.768381 | 7 | 0 | 7 |
| SPTLC1 | HDHD2 | 0.765539 | 4 | 0 | 4 |
| SPTLC1 | GRPEL2 | 0.764104 | 7 | 0 | 7 |
| SPTLC1 | RNF141 | 0.763995 | 11 | 0 | 11 |
| SPTLC1 | GSKIP | 0.763083 | 6 | 0 | 6 |
| SPTLC1 | KRT78 | 0.758677 | 6 | 0 | 6 |
| SPTLC1 | RAB11A | 0.756808 | 11 | 0 | 11 |
| SPTLC1 | ACPP | 0.754718 | 10 | 0 | 10 |
| SPTLC1 | MFSD5 | 0.752856 | 11 | 0 | 11 |
| SPTLC1 | FRMD4B | 0.752263 | 11 | 0 | 11 |
| SPTLC1 | ZNF426 | 0.752048 | 11 | 0 | 11 |
For details and further investigation, click here
